Shear wave elastography in chronic kidney disease – the physics and clinical application

Ng, Kwan Hoong; Wong, Jeannie Hsiu Ding; Leong, Sook Sam

doi:10.1007/s13246-023-01358-w

Phys Eng Sci Med

2023

DOI: 10.1007/s13246-023-01358-w

|View full text |Cite

Shear wave elastography in chronic kidney disease – the physics and clinical application

Kwan Hoong Ng,

Jeannie Hsiu Ding Wong,

Sook Sam Leong

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Shear‐Wave Elastography Improves Diagnostic Accuracy in Chronic Kidney Disease Compared to Conventional Ultrasound

Jiang,

Zang,

Gao

et al. 2024

J of Clinical Ultrasound

View full text Add to dashboard Cite

PurposeNon‐invasive tests are increasingly demanded for diagnosing and prognostication of chronic kidney disease (CKD). Shear‐wave elastography (SWE), an emerging technique for measuring tissue stiffness, shows promise for distinguishing between individuals with different stages of renal fibrosis. This study aimed to compare the diagnostic accuracy of two‐dimensional SWE (2D‐SWE) and conventional ultrasound for detecting CKD, employing renal biopsy as the gold standard.MethodsFrom May 2020 to October 2023, this prospective study included 30 healthy volunteers and 169 patients with CKD who had undergone 2D‐SWE and conventional ultrasound of both kidneys. Cortical and medullary stiffness, cortical pixel intensity, renal length, parenchymal and cortical thickness, interlobar artery peak systolic velocity, end‐diastolic velocity (EDV), and resistive index were measured. The diagnostic accuracy of 2D‐SWE and conventional ultrasound was compared using the receiver operating characteristic curve (ROC) and Delong test.ResultsFor diagnosing CKD, the area under the ROC (AUC) of cortical stiffness (0.96 [95% CI, 0.93, 0.99]) was significantly higher than that of all conventional ultrasound parameters, including EDV (0.78 [95% CI, 0.71, 0.86]) and cortical thickness (0.74 [95% CI, 0.67, 0.80]). The sensitivity of cortical stiffness (91%) was significantly higher than that of EDV (68%) and cortical thickness (53%). No significant difference was found in the specificity of cortical stiffness (96%) compared to that of EDV (79%) and cortical thickness (100%).ConclusionTwo‐dimensional SWE showed higher diagnostic accuracy than that of conventional ultrasound for detecting CKD.

show abstract

Shear‐Wave Elastography Improves Diagnostic Accuracy in Chronic Kidney Disease Compared to Conventional Ultrasound

Jiang,

Zang,

Gao

et al. 2024

J of Clinical Ultrasound

View full text Add to dashboard Cite

show abstract

The bridge is upon us; let’s cross them

Kadri,

2024

Health Technol.

View full text Add to dashboard Cite

Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes

Zhang,

Musah

2024

Bioengineering

View full text Add to dashboard Cite

Stem cell fate decisions, including proliferation, differentiation, morphological changes, and viability, are impacted by microenvironmental cues such as physical and biochemical signals. However, the specific impact of matrix elasticity on kidney cell development and function remains less understood due to the lack of models that can closely recapitulate human kidney biology. An established protocol to differentiate podocytes from human-induced pluripotent stem (iPS) cells provides a promising avenue to elucidate the role of matrix elasticity in kidney tissue development and lineage determination. In this study, we synthesized polyacrylamide hydrogels with different stiffnesses and investigated their ability to promote podocyte differentiation and biomolecular characteristics. We found that 3 kPa and 10 kPa hydrogels significantly support the adhesion, differentiation, and viability of podocytes. Differentiating podocytes on a more compliant (0.7 kPa) hydrogel resulted in significant cell loss and detachment. Further investigation of the mechanosensitive proteins yes-associated protein (YAP) and synaptopodin revealed nuanced molecular distinctions in cellular responses to matrix elasticity that may otherwise be overlooked if morphology and cell spreading alone were used as the primary metric for selecting matrices for podocyte differentiation. Specifically, hydrogels with kidney-like rigidities outperformed traditional tissue culture plates at modulating the molecular-level expression of active mechanosensitive proteins critical for podocyte health and function. These findings could guide the development of physiologically relevant platforms for kidney tissue engineering, disease modeling, and mechanistic studies of organ physiology and pathophysiology. Such advances are critical for realizing the full potential of in vitro platforms in accurately predicting human biological responses.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Shear wave elastography in chronic kidney disease – the physics and clinical application

Cited by 3 publications

References 74 publications

Shear‐Wave Elastography Improves Diagnostic Accuracy in Chronic Kidney Disease Compared to Conventional Ultrasound

Shear‐Wave Elastography Improves Diagnostic Accuracy in Chronic Kidney Disease Compared to Conventional Ultrasound

The bridge is upon us; let’s cross them

Mechanosensitive Differentiation of Human iPS Cell-Derived Podocytes

Contact Info

Product

Resources

About