Shear wave elastography of the spleen using elastography point quantification: stiffness values in healthy children

Bhatia, Anmol; Bhatia, Harsimran; Saxena, Akshay Kumar; Lal, Sadhna; Sodhi, Kushaljit Singh

doi:10.1007/s00261-022-03519-z

Cited by 9 publications

(14 citation statements)

References 16 publications

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“…The spleen can also easily be examined with UE and was found to be stiffer than liver and kidneys in healthy children and showed age-related changes in one study [ 43 ] that were not proven in others [ 44 , 45 ]. Normal values for spleen stiffness were obtained with no difference in the mean values using two types of ultrasound transducers [ 6 ] or when using different probe positions [ 45 ].…”

Section: Spleen Ultrasound Elastography In Childrenmentioning

confidence: 99%

Ultrasound Elastography in Children

Močnik

Varda

2023

Children

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Ultrasound elastography is a novel ultrasound technique, being extensively researched in children in the last decade. It measures tissue elasticity with the observation of tissue response after an external stimulus. From research to clinical practice, ultrasound elastography has evolved significantly in liver fibrosis evaluation in children; however, several other applications of the technique are available in both clinical practice and research environments. Practically, in children any organ can be assessed, including the brain in early ages, along with muscle and connective tissue elasticity evaluation, spleen, kidney, skin, lymphatic tissue, etc. The elastography method, age, body mass index and technical points should be considered when performing ultrasound elastography. This review highlights its vast potential as a diagnostic tool in the pediatric population, where ultrasound is a dominant imaging tool; however, the indications and exam protocol for its clinical use in several fields in pediatrics have yet to be elucidated.

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Section: Spleen Ultrasound Elastography In Childrenmentioning

confidence: 99%

Ultrasound Elastography in Children

Močnik

Varda

2023

Children

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“…As a result of that, SWE can be beneficial in differential diagnosis about the diseases which affect spleen. While numerous studies in the literature have examined the relationship between spleen stiffness and the severity of liver fibrosis in patients with portal hypertension, studies focusing on elastography examinations in patients with spleen enlargement due to causes other than portal hypertension are limited in number and have small sample sizes [17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Shear-Wave Ultrasonographic Elastography in Pediatric Spleen and Its Role in Differential Diagnosis

Cetin,

Tokur,

Bozkurt

et al. 2024

Preprint

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: Shear-wave elastography (SWE) has become popular in clinical practice for many diseases.However, there are not adequate research for spleen-related diseases.This study aimed to investigate the potential of quantitative values obtained through SWE in evaluating spleen pathologies in the pediatric population and to demonstrate its perfomance to differentiate splenomegaly-related diseases.Research group retrospectively included children with pathological diagnoses related to spleen from November 2016 to April 2021 and they were categorized three groups as portal hypertension (PH), benign lymphoid hyperplasia (BLH), malignant infiltration (MI).Spleen sizes and parenchymal stiffness were also calculated for each group.Subsequently, mean spleen stiffness in each compared with normal values within the same age group.In total 2781 children (1379 children for study group, 1402 children for control group) were enrolled to the study.The highest stiffness were observed in the PH group, which is statistically higher than others (p&lt;0.05). Although the mean spleen stiffness in the group with BLH was higher than the control and MI group, the difference was not statistically significant (p=0.08).The mean stiffness in the group with MI was significantly lower than both the control group (p=0.005) and PH (p=0.01).In conclusion, using SWE in the differential diagnosis of etiologies causing splenomegaly, could make important contribution.

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“…[4][5][6][7][8][9] It is being used to evaluate different pathologies in various organs across different age groups in different organs. [10][11][12][13][14] In addition, it may help assess tissue elasticity and predict the course of organ dysfunction. [11][12][13][14] SWE has been proven simple and valuable in various organs such as the liver, spleen, and breast in the adult population; however, limited data is available regarding the use of SWE in defining gallbladder wall characteristics.…”

Section: Introductionmentioning

confidence: 99%

“…[10][11][12][13][14] In addition, it may help assess tissue elasticity and predict the course of organ dysfunction. [11][12][13][14] SWE has been proven simple and valuable in various organs such as the liver, spleen, and breast in the adult population; however, limited data is available regarding the use of SWE in defining gallbladder wall characteristics. SWE has been shown to help in the differentiation of various benign and malignant disorders of the gallbladder.…”

Section: Introductionmentioning

confidence: 99%

“…Shear wave elastography (SWE) is a technique that measures the shear wave velocity of a particular tissue which is directly proportional to the stiffness of the tissue 4–9 . It is being used to evaluate different pathologies in various organs across different age groups in different organs 10–14 . In addition, it may help assess tissue elasticity and predict the course of organ dysfunction 11–14 .…”

Section: Introductionmentioning

confidence: 99%

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Two‐dimensional Shear Wave Elastography: Utility in Differentiating Gallbladder Cancer From Chronic Cholecystitis

Soundararajan

Dutta

Bhatia

et al. 2023

J of Ultrasound Medicine

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Objective To study the utility of 2D shear wave elastography (SWE) and ascertain cut‐off values of shear wave elasticity (SWe) to differentiate benign and malignant thickening of the gallbladder wall. Methods This study was a prospective study of patients with symptomatic gallstone disease (GSD, n = 51) and gallbladder cancer (GBC, n = 46) and controls without any biliary disease (n = 46). All the participants underwent 2D USG and SWE of the gallbladder. Grey‐scale ultrasound and SWE were done in the different regions in the gallbladder. Results The median age of the patients with GSD was 49 years (interquartile range [IQR]: 33–55), GBC was 55 years (IQR: 46–65), and controls was 37 years (IQR: 27–48.25). In patients with GBC, asymmetrical mural thickening was the predominant imaging pattern (n = 24, 52.2%). The mean SWe of the abnormal area in GBC (34.99 ± 17.77 kPa [n = 46]) was significantly higher than that of the uninvolved region (18.27 ± 8.12 kPa [n = 35]; P < .01). The mean SWe of the uninvolved region in GBC (18.27 ± 8.12 kPa [n = 35]) was also significantly higher (P < .01) than that of GSD (12.27 ± 4.13 kPa [n = 51]) and controls (10.52 ± 3.75 kPa [n = 46]). On ROC analysis, AUC of 0.927, at a cut‐off of 20 kPa, sensitivity was 91.3%, specificity was 83.5%, positive likelihood ratio was 5.54, and negative likelihood ratio was 0.10 to diagnose GBC. Conclusion The 2D SWE is a reliable adjunctive tool to grey‐scale USG in differentiating the malignant from benign gallbladder wall and may help to pick up early malignancy in GSD.

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Shear wave elastography of the spleen using elastography point quantification: stiffness values in healthy children

Cited by 9 publications

References 16 publications

Ultrasound Elastography in Children

Ultrasound Elastography in Children

Shear-Wave Ultrasonographic Elastography in Pediatric Spleen and Its Role in Differential Diagnosis

Two‐dimensional Shear Wave Elastography: Utility in Differentiating Gallbladder Cancer From Chronic Cholecystitis

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