The Cook Inlet region of south-central Alaska is located toward the eastern end of the 4,000 km-long Aleutian-Alaska subduction zone, where the Pacific plate subducts under North America. Plutonic rocks and basin-deposited strata indicate that subduction has persisted in this region for more than 200 Ma (Fisher & Magoon, 1978;Jarrard, 1986). The Cook Inlet segment of the subduction zone exhibits abundant seismicity down to approximately 200 km depth, as well as active volcanoes (Figure 1). Here, we use recordings from these intraslab earthquakes to characterize the anisotropic structure of the subduction zone.Plate motion has often been linked to shearing and flow in the upper mantle (Long & Wirth, 2013), including viscous coupling between the downgoing slab and the overlying mantle (van Keken, 2003). Shearwave splitting has been utilized to study anisotropy in both the crust and upper mantle in various regions around the globe (Savage, 1999;Silver & Chan, 1991). In subduction zones, it is predicted that multiple types and layers of olivine fabrics and other sources of anisotropy may be present (Jung & Karato, 2001;Karato et al., 2008;Silver & Savage, 1994). Changes in olivine fabric have been evoked to explain sharp transitions of shear-wave splitting fast directions from arc-parallel in the arc and forearc to arc-perpendicular in the backarc without requiring a change in mantle flow direction (Nakajima & Hasegawa, 2004;Kneller et al., 2005). However, even a small presence of other mantle minerals, such as antigorite, can have a strong influence on the observed splitting pattern (Horn et al., 2020). Furthermore, organized melt channels can be