Shed syndecan-2 inhibits angiogenesis

Rossi, Giulia De; Evans, Alun R.; Kay, Emma; Woodfin, Abigail; McKay, Tristan R.; Nourshargh, Sussan; Whiteford, James R.

doi:10.1242/jcs.153015

Cited by 64 publications

(37 citation statements)

References 34 publications

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“…Similar to what observed with syndecan-1, the shed ectodomains of syndecan-2 and syndecan-4 modulate angiogenesis. Shed syndecan-2 inhibits angiogenesis via a paracrine interaction with Cluster of Differentiation 148 (CD148), which in turn deactivates the α 1 β 1 and α 2 β 1 integrins, two main angiogenesis receptors [186]. The ectodomain of syndecan-4 is cleaved by the secreted metalloprotease A Disintegrin And Metalloproinase with Thrombospondin motifs 1 (ADAMTS1).…”

Section: Proteoglycans: Complex Functions From the Protein Core Anmentioning

confidence: 99%

Extracellular Matrix, a Hard Player in Angiogenesis

Mongiat

Andreuzzi

Tarticchio

et al. 2016

IJMS

172

133

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The extracellular matrix (ECM) is a complex network of proteins, glycoproteins, proteoglycans, and polysaccharides. Through multiple interactions with each other and the cell surface receptors, not only the ECM determines the physical and mechanical properties of the tissues, but also profoundly influences cell behavior and many physiological and pathological processes. One of the functions that have been extensively explored is its impingement on angiogenesis. The strong impact of the ECM in this context is both direct and indirect by virtue of its ability to interact and/or store several growth factors and cytokines. The aim of this review is to provide some examples of the complex molecular mechanisms that are elicited by these molecules in promoting or weakening the angiogenic processes. The scenario is intricate, since matrix remodeling often generates fragments displaying opposite effects compared to those exerted by the whole molecules. Thus, the balance will tilt towards angiogenesis or angiostasis depending on the relative expression of pro- or anti-angiogenetic molecules/fragments composing the matrix of a given tissue. One of the vital aspects of this field of research is that, for its endogenous nature, the ECM can be viewed as a reservoir to draw from for the development of new more efficacious therapies to treat angiogenesis-dependent pathologies.

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Section: Proteoglycans: Complex Functions From the Protein Core Anmentioning

confidence: 99%

Extracellular Matrix, a Hard Player in Angiogenesis

Mongiat

Andreuzzi

Tarticchio

et al. 2016

IJMS

172

133

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“…120 SDC2 may also modulate immune cell adhesion and migration. Shedding of SDC2 is also increased by inflammatory signals, such as TNF, 121 potentially via ADAM17 activation. 122 Such shedding may enable secondary downregulation of SDC2 biological activity on the cell surface.…”

Section: Syndecansmentioning

confidence: 99%

Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes

Swart

Troeberg

2018

J Histochem Cytochem.

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Heparan sulfate (HS) proteoglycans on immune cells have the ability to bind to and regulate the bioactivity more than 400 bioactive protein ligands, including many chemokines, cytokines, and growth factors. This makes them important regulators of the phenotype and behavior of immune cells. Here we review how HS biosynthesis in macrophages is regulated during polarization and in chronic inflammatory diseases such as rheumatoid arthritis, atherosclerosis, asthma, chronic obstructive pulmonary disease and obesity, by analyzing published micro-array data and mechanistic studies in this area. We describe that macrophage expression of many HS biosynthesis and core proteins is strongly regulated by macrophage polarization, and that these expression patterns are recapitulated in chronic inflammation. Such changes in HS biosynthetic enzyme expression are likely to have a significant impact on the phenotype of macrophages in chronic inflammatory diseases by altering their interactions with chemokines, cytokines, and growth factors. (J Histochem Cytochem 67:9-27, 2019)

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“…These PGs play important roles in cell adhesion, proliferation, growth factor signaling, embryogenesis, tissue morphogenesis, and cartilage development [12-14]. The membrane-bound syndecans and glypicans are involved in processes such as cell growth and angiogenesis [15, 16]. The syndecan family consists four members, syndecans 1, 2, 3, and 4, which carry HS and/or CS chains.…”

Section: Introductionmentioning

confidence: 99%

Extracellular matrix proteomics in schizophrenia and Alzheimer’s disease

Sethi

Zaia

2016

Anal Bioanal Chem

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Brain extracellular matrix (ECM) is a highly organized system that consists of collagens, non-collagenous proteins, glycoproteins, hyaluronan and proteoglycans (PGs). Recognized physiological roles of ECM include developmental regulation, tissue homeostasis, cell migration, proliferation, differentiation, neuronal plasticity, and neurite outgrowth. Aberrant ECM structure is associated with brain neurodegenerative conditions. This review focuses on two neurodegenerative conditions, schizophrenia (Sz) and Alzheimer's disease (AD), and summarizes recent findings of altered ECM components, including PGs, glycosaminoglycans (GAGs), proteins and glycoproteins, and proteins and genes related to other brain components. The scope includes immunohistochemical, genomics, transcriptomics, proteomics and glycomics studies, and a critical assessment of current state of proteomics studies for neurodegenerative disorders. The intent is to summarize the ECM molecular alterations associated with neurodegenerative pathophysiology.

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Shed syndecan-2 inhibits angiogenesis

Cited by 64 publications

References 34 publications

Extracellular Matrix, a Hard Player in Angiogenesis

Extracellular Matrix, a Hard Player in Angiogenesis

Effect of Polarization and Chronic Inflammation on Macrophage Expression of Heparan Sulfate Proteoglycans and Biosynthesis Enzymes

Extracellular matrix proteomics in schizophrenia and Alzheimer’s disease

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