2006
DOI: 10.1016/j.bbagen.2005.11.014
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Shedding and uptake of gangliosides and glycosylphosphatidylinositol-anchored proteins

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Cited by 74 publications
(51 citation statements)
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References 277 publications
(300 reference statements)
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“…Numerous factors can influence the incorporation and the rate of transfer of exogenously added gangliosides into cell membranes. Under some conditions, gangliosides added at lower concentrations could be more effective at entering membranes than when added at higher concentrations, as a result of micelle formation at higher concentrations (44). Collectively, these findings indicate that the influence of gangliosides on angiogenesis and cell signaling events is dependent to a large extent on the type of microenvironment and on the concentrations of gangliosides and growth factors in the microenvironment.…”
Section: Discussionmentioning
confidence: 66%
“…Numerous factors can influence the incorporation and the rate of transfer of exogenously added gangliosides into cell membranes. Under some conditions, gangliosides added at lower concentrations could be more effective at entering membranes than when added at higher concentrations, as a result of micelle formation at higher concentrations (44). Collectively, these findings indicate that the influence of gangliosides on angiogenesis and cell signaling events is dependent to a large extent on the type of microenvironment and on the concentrations of gangliosides and growth factors in the microenvironment.…”
Section: Discussionmentioning
confidence: 66%
“…5Be and Refs. 30, 32), including type I cells, could result from gene expression and/or shedding and membrane insertion of CEACAM6, a known property of GPI proteins (27) and of CEACAM6 in A549 cells (31). We, therefore, further examined this issue as summarized in Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Given that serum/plasma GSLs originate from a variety of tissues and enter the circulation as a result of shedding processes ( 13 ), the serum/plasma GSL-glycome would be a good tool with which to identify and/or screen diseaserelated biomarkers. The presence of gangliosides in human serum was fi rst described in 1963 ( 14 ).…”
Section: Acid Hydrolysis and Sequential Exoglycosidase Digestionmentioning
confidence: 99%