Shedding light on pharmacists’ knowledge of kidney stones’ etiology and treatment

Almomani, Ensaf Y.; Jarrar, Wassan; Alhadid, Amani; Hamadneh, Lama; Qablan, Ahmad; Almomani, Huda Y.

doi:10.18549/pharmpract.2022.3.2712

Cited by 4 publications

(3 citation statements)

References 41 publications

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“…Результати аналізу сечі часто свідчать про наявність мікроскопічної гематурії, також можлива кристалурія, проте вона не є діагностичною ознакою СКХ, оскільки може бути й у здорових осіб. Наявність лейкоцитів у сечі свідчить про наявність запалення, збільшення лейкоцитарної естерази та нітритів може вказувати на наявність інфекції, що лежить в основі захворювання [16][17][18].…”

Section: клінічна картина скхunclassified

Urolithiasis: Modern Approaches to Classification, Diagnosis and Treatment

Samchuk,

Krasiuk,

Iskenderov

et al. 2023

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Urinary stone disease (USD) is the most common and progressive disease of the urinary system, which is characterized by frequent exacerbations and a severe course. This is a complex disease caused by various causes, in which several biochemical processes are involved, occurring not only in the urinary system, but also in the whole organism. USD depends on geographical, climatic, ethnic, dietary and genetic factors. Over the past 20 years there has been an increase prevalence of this disease. The course of USD is characterized by the acute and chronic pyelonephritis and frequent recurrence, which leads to the development of renal failure, disability and fatal consequences. Calculus can form de novo anywhere in the urinary tract. The pathophysiology of USD differs depending on the place of stone formation and depends on endogenous and exogenous factors. Urinary tract stones are classified depending on etiology, location, size, number, frequency of occurrence, and radiopacity. The main symptoms of USD are pain of various nature; microscopic hematuria; dysuria, which most often indicates the presence of a stone in the urinary bladder or a low location in the ureters; discharge of crystals of urinary salts or concretions; increased body temperature. The diagnosis of USD is based on a carefully history taking and physical examination, which allows to determine the correct direction of diagnostic approach, which include laboratory and instrumental methods of diagnosis. Ultrasound diagnosis is used as the main method for visualization of calculi, but recently non contrast-enhanced computed tomography has become the standard for the diagnosis of acute low back pain, replacing intravenous urography. The choice of treatment is based on many parameters, such as the number, size, morphology, shape, volume, mobility, hardness and location of the stones and is individualized for each patient. There are two main approaches: conservative treatment and surgic al one. Medicinal treatment of USD is used primarily to prevent the repeated formation of new stones or to increase those inclusions that are already present in the organs. Drug therapy is carried out with the aim of normalizing processes in the body, the failure of which leads to the development of pathology. However, conservative treatment has its limitations and is most often used as a symptomatic treatment. Open laparoscopic interventions are rarely used recently, minimally invasive methods are more popular: extracorporeal shock-wave lithotripsy; ureterorenoscopy; percutaneous nephrolithotomy. Taking into account the increase in the prevalence of USD in Ukraine and disability (the third place among the general spectrum of causes of disability in urological practice), the article analyzes and reviews modern approaches to classification, early and accurate diagnosis, and choosing a timely and correct method of treatment.

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Section: клінічна картина скхunclassified

Urolithiasis: Modern Approaches to Classification, Diagnosis and Treatment

Samchuk,

Krasiuk,

Iskenderov

et al. 2023

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“…Although the literature demonstrates that community pharmacists tend to have adequate knowledge of the etiology and treatment of KS, a gap exists in their awareness of how external factors, such as the consumption of vitamins or the use of home remedies, can influence KS formation. This is likely due to inadequate awareness among inexperienced community pharmacists of patients' use of home remedies or medicinal plants [32].…”

Section: Challenges and Obstacles Faced By Community Pharmacists When...mentioning

confidence: 99%

Shedding light on community pharmacist–directed point-of-care screening and education for patients with kidney stones: Implications and future research

Jairoun

Al‐Hemyari

El‐Dahiyat

et al. 2023

Research in Social and Administrative Pharmacy

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“…Food-drug interactions can be defined as changes in the pharmacokinetics and/or pharmacodynamics of a medication or any dietary component, or they may compromise nutritional status associated with, or as a result of, combining food and medication [3,4,5]. Older patients and those with chronic diseases are particularly at risk as this population group consume more than one-third of prescribed medications [6].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Impact of Orange Juice on Apixaban Pharmacokinetics in Healthy Rats

Al-Abdallat,

Al-Ani,

Alshalabi

et al. 2024

Jordan j. pharm. sci.

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Juice derived from the "sweet orange" cultivar is widely consumed and is considered one of the most popular juices globally. It contains many bioactive compounds that can interact with pharmaceutical agents. This study aimed to assess the impact of oral co-ingestion of orange juice (OJ) and Apixaban (AP) on the fundamental pharmacokinetic characteristics of AP, Cmax, and AUC0-t. Two groups of Wistar rats were used in this study: one was given the drug alone, and the other was given the drug with OJ. Each animal was given 10 ml of freshly squeezed orange juice two hours before the administration of AP at a dose of 5 mg/kg and 10 ml concurrently with it. The plasma samples were withdrawn up to 72 hours later and analyzed using the LC/MS technique, and pharmacokinetic parameters were analyzed using Winnonlin version 8.3. The findings indicated a statistically significant increase in Cmax of AP from 28.12±3.78 ng/mL to 56.97±9.8 ng/mL, as well as an increase in AUC0-12 levels from 285.04±24.5 ng. hr/mL to 827.17±46.58 ng.hr/mL when ingested with OJ, without a significant change in Tmax and half-life (t1/2). The results determined that consuming sweet OJ exhibits a noteworthy interaction with orally administered AP.

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Shedding light on pharmacists’ knowledge of kidney stones’ etiology and treatment

Cited by 4 publications

References 41 publications

Urolithiasis: Modern Approaches to Classification, Diagnosis and Treatment

Urolithiasis: Modern Approaches to Classification, Diagnosis and Treatment

Shedding light on community pharmacist–directed point-of-care screening and education for patients with kidney stones: Implications and future research

Evaluation of the Impact of Orange Juice on Apixaban Pharmacokinetics in Healthy Rats

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