Sheep do not have a major role in bovine herpesvirus 1 transmission

Hage, J. Joris; Vellema, P.; Schukken, Y.H.; Barkema, Herman W.; Rijsewijk, F.A.M.; Oirschot, J.T. van; Wentink, G. H.

doi:10.1016/s0378-1135(97)00083-7

Cited by 33 publications

(18 citation statements)

References 10 publications

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“…Maintenance of latent infection is mostly controlled by LR gene and ORF-E. LR gene inhibits bICP0 RNA expression, which is a viral promoter, and ORF-E maintains the neural health (Jones & Chowdhury 2008). The cattle that are seronegative for BHV-1 antibodies may be latently infected with BHV-1 (Hage et al 1997). Latency may also occur in non-neural sites such as tonsillar lymphoid cells (Winkler et al 2000), peripheral blood (Fuchs et al 1999), and lymphnodes (Mweene et al 1996).…”

Section: Latency Developmentmentioning

confidence: 99%

“…Detection of antibodies against BHV-1 in sheep suggests that sheep may play a crucial role in the epidemiology and maintenance of BHV-1 in the environment (Elazhary et al 1984;Jetteur et al 1990). However, sheep is unlikely to play any role in BHV-1 transmission (Hage et al 1997). In the UK, the prevalence of BHV-1 has increased to 83% in unvaccinated herds (Woodbine et al 2009).…”

Section: Epidemiologymentioning

confidence: 99%

“…The antibody response includes mostly neutralizing antibodies, and contributes to antiviral antibody-dependent cellular cytotoxicity (Tikoo et al 1995a), which is often complement mediated (Rouse et al 1977). Antibodies in the circulation may be recorded for an endurable period, like 3 years following BHV-1 vaccination (Hage et al 1997). In contrast, the antibody response to the V155 strain of BHV-1 persists at maximal levels from 7 to 21 days after infection (Bagust 1972).…”

Section: Humoral Responsementioning

confidence: 99%

See 2 more Smart Citations

Bovine herpesvirus-1 (BHV-1) – a re-emerging concern in livestock: a revisit to its biology, epidemiology, diagnosis, and prophylaxis

Biswas

Bandyopadhyay

Dimri

et al. 2013

Veterinary Quarterly

100

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Bovine herpesvirus-1 (BHV-1) is known to cause several diseases worldwide. It is a double-stranded DNA virus consisting of 33 structural proteins out of which 13 are associated with the envelope. Based on genomic analysis and viral peptide patterns, BHV-1 virus can be divided into several subtypes like BHV-1.1, BHV-1.2, and BHV-1.3. However, all subtypes are antigenically similar. The symptoms of the related diseases are mainly non-life-threatening but have a rather wide host range that limits animal trade. The different modes of transmission as unique feature of this virus and the tendency to cause infection in the early age with latency development in trigeminal and sacral ganglion cause huge economic losses around the world. The virus also affects endangered bovine species like mithun (Bos frontalis) and yak (Poephagus grunniens). The disease can be diagnosed by using conventional procedures (like cell culture, immune-histopathology, and enzymelinked immunosorbent assay (ELISA)) as well as highly sensitive modern techniques (like nested PCR and southern hybridization) with the virus neutralization test regarded as gold standard. With the currently available diagnostic tests it is not possible to identify animals which have a latent BHV-1 infection. Different types of modern and conventional vaccines are available for immunoprophylaxis. Inactivated vaccines are not as efficacious as modified live virus (MLV) vaccines. Marker vaccines allow the distinction between vaccinated and naturally infected animals. In this review the present status of BHV-1 around the world will be addressed besides the current knowledge with regard to its biology, epidemiology, diagnosis, and prophylaxis.

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Section: Latency Developmentmentioning

confidence: 99%

Section: Epidemiologymentioning

confidence: 99%

Section: Humoral Responsementioning

confidence: 99%

See 1 more Smart Citation

Bovine herpesvirus-1 (BHV-1) – a re-emerging concern in livestock: a revisit to its biology, epidemiology, diagnosis, and prophylaxis

Biswas

Bandyopadhyay

Dimri

et al. 2013

Veterinary Quarterly

100

View full text Add to dashboard Cite

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“…In the natural situation BoHV-1 was detected in acutely and latently infected sheep. However sheep do not play a major role in the transmission of BoHV-1 to cattle [66]. Successful BoHV-1 infections were experimentally obtained in sheep and goats.…”

Section: Epidemiologymentioning

confidence: 99%

Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

et al. 2007

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-Bovine herpesvirus 1 (BoHV-1), classified as an alphaherpesvirus, is a major pathogen of cattle. Primary infection is accompanied by various clinical manifestations such as infectious bovine rhinotracheitis, abortion, infectious pustular vulvovaginitis, and systemic infection in neonates. When animals survive, a life-long latent infection is established in nervous sensory ganglia. Several reactivation stimuli can lead to viral re-excretion, which is responsible for the maintenance of BoHV-1 within a cattle herd. This paper focuses on an updated pathogenesis based on a molecular characterization of BoHV-1 and the description of the virus cycle. Special emphasis is accorded to the impact of the latency and reactivation cycle on the epidemiology and the control of BoHV-1. Several European countries have initiated BoHV-1 eradication schemes because of the significant losses incurred by disease and trading restrictions. The vaccines used against BoHV-1 are described in this context where the differentiation of infected from vaccinated animals is of critical importance to achieve BoHV-1 eradication.

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“…Although they are usually subclinical in sheep, acute BoHV-1 infections can sometimes be associated with clinical signs, such as acute, fatal pneumonia, or with aborted foetuses [144]. However, sheep do not play a major role in BoHV-1 transmission to calves [50].…”

Section: Bovine Herpesvirus 1 Infection Of Goats and Sheepmentioning

confidence: 99%

Ruminant alphaherpesviruses related to bovine herpesvirus 1

et al. 2006

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-Herpesviruses have mainly co-evolved with their hosts for millions of years. Consequently, different related host species may have been infected by various genetically related herpesviruses. Illustrating this concept, several ruminant alphaherpesviruses have been shown to form a cluster of viruses closely related to bovine herpesvirus 1 (BoHV-1): namely bovine herpesvirus 5, bubaline herpesvirus 1, caprine herpesvirus 1, cervid herpesviruses 1 and 2 and elk herpesvirus 1. These viruses share common antigenic properties and the serological relationships between them can be considered as a threat to BoHV-1 eradication programmes. BoHV-1 is a herpesvirus responsible for infectious bovine rhinotracheitis, which is a disease of major economic concern. In this article, the genetic properties of these ruminant alphaherpesviruses are reviewed on a comparative basis and the issue of interspecific recombination is assessed. The pathogenesis of these infections is described with emphasis on the host range and crossing of the host species barrier. Indeed, the non bovine ruminant species susceptible to these ruminant alphaherpesviruses may be potential BoHV-1 reservoirs. The differential diagnosis of these related infections is also discussed. In addition, available epidemiological data are used to assess the potential of cross-infection in ruminant populations. A better knowledge of these ruminant alphaherpesvirus infections is essential to successfully control infectious bovine rhinotracheitis.

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Sheep do not have a major role in bovine herpesvirus 1 transmission

Cited by 33 publications

References 10 publications

Bovine herpesvirus-1 (BHV-1) – a re-emerging concern in livestock: a revisit to its biology, epidemiology, diagnosis, and prophylaxis

Bovine herpesvirus-1 (BHV-1) – a re-emerging concern in livestock: a revisit to its biology, epidemiology, diagnosis, and prophylaxis

Bovine herpesvirus 1 infection and infectious bovine rhinotracheitis

Ruminant alphaherpesviruses related to bovine herpesvirus 1

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