Sheep Pulmonary Adenomatosis: Characterization of Two Pathological Forms Associated with Jaagsiekte Retrovirus

García-Goti, M; González, Lorenzo; Cousens, Chris; Cortabarrı́a, N.; Extramiana, A. B.; Minguijón, E.; Ortı́n, A.; Heras, M. De las; Sharp, JM

doi:10.1053/jcpa.1999.0344

Cited by 56 publications

(70 citation statements)

References 21 publications

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“…Hence, ovine cell lines issued from various tissues may be infected in vitro by JSRV, however viral production stays weak [58]. Presence of viral DNA can be demonstrated in naturally infected animals in lymphoid tissues, alveolar macrophages and in peripheral blood mononuclear cells such as monocytes or B and T lymphocytes [29,33,37,56,75].…”

Section: Jsrv Tropismmentioning

confidence: 99%

Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep

et al. 2007

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-Jaagsiekte Sheep Retrovirus (JSRV) is a betaretrovirus infecting sheep. This virus is responsible for a pulmonary adenocarcinoma, by transformation of epithelial cells from the bronchioli and alveoli. This animal cancer is similar to human bronchioloalveolar cancer (BAC), a specific form of human lung cancer for which a viral aetiology has not yet been identified. JSRV interacts with target cells through the membrane receptor Hyal2. The JSRV genome is simple and contains no recognised oncogene. It is now well established that the viral envelope protein is oncogenic by itself, via the cytoplasmic domain of the transmembrane glycoprotein and some domains of the surface glycoprotein. Activation of the PI3K/Akt and MAPK pathways participates in the envelopeinduced transformation. Tumour development is associated with telomerase activation. This review will focus on the induction of cancer by JSRV.

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Section: Jsrv Tropismmentioning

confidence: 99%

Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep

et al. 2007

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“…Ovine pulmonary adencarcinoma (OPA), also known as sheep pulmonary adenomatosis or Jaagsiekte (Palmarini and Fan 2001), is a transmissible lung cancer (Garcia-Goti et al 2000;Sharp and DeMartini 2003) that is caused by a naturally occurring Jaagsiekte sheep retrovirus (JSRV), a member of the genus betaretroviruses of the family retroviridae (York et al 1992;Palmarini et al 1999;DeMartini et al 2001). It most often occurs in sheep aged 2-4 years, although the disease may affect lambs as young as 2 months old (DeMartini et al 2001).…”

Section: Introductionmentioning

confidence: 99%

“…The presumable mechanism of JSRV oncogenesis is expression of a viral oncogene by insertional activation of host cell oncogenes or by inactivation of host cell tumor suppressor proteins (Wootton et al 2006). Tumor metastasis can be found in regional lymph nodes and rarely extrathoracic tissues (Garcia-Goti et al 2000;Platt et al 2002;Hudachek et al 2010). …”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical and histopathological findings of ovine pulmonary adenocarcinoma (Jaagsiekte) in Egyptian sheep

Oda

Youssef

2011

Trop Anim Health Prod

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Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring retrovirus-induced transmissible lung cancer in sheep. Lungs and associated (bronchial and mediastinal) lymph nodes of seven sheep with OPA were examined. Lungs had few multifocal consolidated slightly elevated gray to white masses ranging from 0.5 to 3 cm in diameter. Histopathologically, these masses appeared as well-differentiated acinar adenocarcinoma with little evidence of anaplasia. The acini composed of well-differentiated cuboidal to low columnar epithelium with clear or vacuolated cytoplasm and low mitotic index. No metastases were observed in the bronchial and mediastinal lymph nodes of any animal. The presence of Jaagsiekte sheep retrovirus (JSRV) was demonstrated in the lungs by immunohistochemistry. JSRV protein was detected in all tumor epithelial cells, histologically normal alveolar type II cells, and few bronchiolar epithelial cells, alveolar macrophages, lymphocytes, and plasma cells. This study is the first to confirm the presence of natural OPA in Egypt.

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“…OPA is a contagious tumour arising from alveolar type II pneumocytes and rarely from non-ciliated bronchiolar (Clara) cells. Tumour metastases can be found in thoracic and occasionally in extrathoracic tissues (6,7,8,22,25). The disease is caused by an exogenous β-retrovirus, known as Jaagsiekte sheep retrovirus (JSRV), which induces oncogenic transformation of alveolar and bronchiolar secretory epithelial cells (21).…”

Section: Introductionmentioning

confidence: 99%

“…OPA occurs naturally in sheep and rarely in goats (21). Although the disease may affect lambs as young as two months old, sheep most often show clinical features at 2-4 years of age (8,12,28). In some affected flocks, the annual mortality rate due to the disease may be as high as 10%-20%, although the rate of 1%-3% is more common (28).…”

Section: Introductionmentioning

confidence: 99%

The Soaking Resistance of Electronic Storage Media

Iraci

2017

Restaurator. International Journal for the Preservation of Library and Archival Material

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Introduction: The aim of this study was to use TaqMan real-time PCR technique to investigate Jaagsiekte sheep retrovirus (JSRV) proviral DNA in whole blood samples of sheep, and compare the results to those of histopathological examinations. Material and Methods: Eighty blood samples from clinically healthy sheep were randomly collected before the animals were slaughtered. Ten tissue samples from each lung and associated caudal mediastinal lymph node were taken. Results: Fifteen (18.75%) blood samples were found to contain proviral DNA, and 11 (13.75%) corresponding lung samples showed microscopic changes consistent with ovine pulmonary adenocarcinoma. None of the samples displayed metastases to the caudal mediastinal lymph nodes. The prominent pattern of neoplastic nodules consisted of acinar (alveolar) form. Conclusion: The results indicated the higher sensitivity of real-time PCR compared to histopathological examinations in detection of ovine pulmonary adenocarcinoma.

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Sheep Pulmonary Adenomatosis: Characterization of Two Pathological Forms Associated with Jaagsiekte Retrovirus

Cited by 56 publications

References 21 publications

Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep

Jaagsiekte Sheep Retrovirus (JSRV): from virus to lung cancer in sheep

Immunohistochemical and histopathological findings of ovine pulmonary adenocarcinoma (Jaagsiekte) in Egyptian sheep

The Soaking Resistance of Electronic Storage Media

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