Semantics-based approaches-founded on the idea of explicitly encoding meaning separately from the data or the application code-are being applied to manufacturing, for example, to enable early manufacturability feedback. These approaches rely on formal, i.e., computer-interpretable, knowledge and rules along with the context or semantics. On the other hand, manufacturing knowledge has been maintained primarily in the form of unstructured English text.It is considered impractical for engineers to author accurate, formal, and structured manufacturing rules. Previous efforts on extracting semantics from unstructured text in manufacturing have focused exclusively on basic concept names and hierarchies. In this context, this dissertation focuses on the development of a semantics-based framework for acquiring more complex manufacturing knowledge, primarily rules, in a formal form, from unstructured English text such as those written in manufacturing handbooks. This dissertation includes the following specific research tasks. First, it studies the problem in manufacturing domain, proposes the formal rule extraction framework, and demonstrates its feasibility. Second, it extends the framework to complement standard Natural Language Processing (NLP) techniques with manufacturing domain knowledge to resolve ambiguities, called as domainspecific ambiguities, that are due to manufacturing-specific meanings implicit in the English text. Finally, this dissertation extends the framework to identify the cases that need input text validation, and provide the relevant feedback to the user to modify the input text for the extraction of correct rules.