Shell and core in monkey and human nucleus accumbens identified with antibodies to calbindin-D28k

Meredith, Gloria E.; Pattiselanno, A.; Groenewegen, Henk J.; Haber, Suzanne N.

doi:10.1002/(sici)1096-9861(19960219)365:4<628::aid-cne9>3.0.co;2-6

Cited by 171 publications

(128 citation statements)

References 81 publications

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“…As shown in our previous study (Mitrano and Smith, 2007) and others (Meredith et al, 1996), calbindin immunoreactivity clearly delineated the boundaries of the shell and core of the nucleus accumbens, hence serving as a guide for the selection of blocks of tissue in subsequent electron microscopic experiments. Tissue from all three cocaine treatment groups and saline-treated animals were immunostained for the two group I mGluRs.…”

Section: Light Microscopic Observationssupporting

confidence: 66%

Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats

2008

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There is significant pharmacological and behavioral evidence that group I metabotropic glutamate receptors (mGluR1a and mGluR5) in the nucleus accumbens play an important role in the neurochemical and pathophysiological mechanisms that underlie addiction to psychostimulants. To further address this issue, we undertook a detailed ultrastructural analysis to characterize changes in the subcellular and subsynaptic localization of mGluR1a and mGluR5 in the core and shell of nucleus accumbens following acute or chronic cocaine administration in rats. After a single cocaine injection (30mg/kg) and 45 minutes withdrawal, there was a significant decrease in the proportion of plasma membrane-bound mGluR1a in accumbens shell dendrites. Similarly, the proportion of plasma membrane-bound mGluR1a was decreased in large dendrites of accumbens core neurons following chronic cocaine exposure (i.e. 1 week treatment followed by three weeks withdrawal). However, neither acute nor chronic cocaine treatments induced significant change in the localization of mGluR5 in accumbens core and shell, which is in contrast with the significant reduction of plasma membranebound mGluR1a and mGluR5 induced by local intra-accumbens administration of the group I mGluR agonist, DHPG. In conclusion, these findings demonstrate that cocaine-induced glutamate imbalance (Smith et al., 1995;Pierce et al., 1996;Reid et al., 1997) has modest effects on the trafficking of group I mGluRs in the nucleus accumbens. These results provide valuable information on the neuroadaptive mechanisms of accumbens group I mGluRs in response to cocaine administration.

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Section: Light Microscopic Observationssupporting

confidence: 66%

Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats

2008

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“…Within the NAcc region of the VS, a subterritory, called the shell, has a particularly important function in the circuitry underlying goal-directed behaviors, behavioral sensitization, and changes in affective states (Carlezon and Wise, 1996;Ito et al, 2004). Although several transmitter and receptor distribution patterns distinguish the shell/core subterritories, calbindin is the most consistent marker for the shell across species (Alheid and Heimer, 1988;Ikemoto et al, 1995;Martin et al, 1993;Meredith et al, 1996;Sato et al, 1993). The shell has some unique connectivities that distinguish it from the rest of the VS (indicated below).…”

Section: Organization Of the Vsmentioning

confidence: 99%

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Haber

Knutson

2009

Neuropsychopharmacol

3,183

193

2,859

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Although cells in many brain regions respond to reward, the cortical-basal ganglia circuit is at the heart of the reward system. The key structures in this network are the anterior cingulate cortex, the orbital prefrontal cortex, the ventral striatum, the ventral pallidum, and the midbrain dopamine neurons. In addition, other structures, including the dorsal prefrontal cortex, amygdala, hippocampus, thalamus, and lateral habenular nucleus, and specific brainstem structures such as the pedunculopontine nucleus, and the raphe nucleus, are key components in regulating the reward circuit. Connectivity between these areas forms a complex neural network that mediates different aspects of reward processing. Advances in neuroimaging techniques allow better spatial and temporal resolution. These studies now demonstrate that human functional and structural imaging results map increasingly close to primate anatomy.

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“…It included much of the region thought to be the nucleus accumbens in both macaque and human species (Meredith et al, 1996). The remaining area was split in half, and the most dorsolateral part was defined as the STRd (Fig.…”

Section: Striatal Seed Areasmentioning

confidence: 99%

Quantitative Investigation of Connections of the Prefrontal Cortex in the Human and Macaque using Probabilistic Diffusion Tractography

Croxson¹,

Johansen‐Berg²,

Behrens³

et al. 2005

J. Neurosci.

380

318

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The functions of prefrontal cortex (PFC) areas are constrained by their anatomical connections. There is little quantitative information about human PFC connections, and, instead, our knowledge of primate PFC connections is derived from tracing studies in macaques. The connections of subcortical areas, in which white matter penetration and hence diffusion anisotropy are greatest, can be studied with diffusion-weighted imaging (DWI) tractography. We therefore used DWI tractography in four macaque and 10 human hemispheres to compare the connections of PFC regions with nine subcortical regions, including several fascicles and several subcortical nuclei. A distinct connection pattern was identified for each PFC and each subcortical region. Because some of the fascicles contained connections with posterior cortical areas, it was also possible to draw inferences about PFC connection patterns with posterior cortical areas. Notably, it was possible to identify similar circuits centered on comparable PFC regions in both species; PFC regions probably engage in similar patterns of regionally specific functional interaction with other brain areas in both species. In the case of one area traditionally assigned to the human PFC, the pars opercularis, the distribution of connections was not reminiscent of any macaque PFC region but, instead, resembled the pattern for macaque ventral premotor area. Some limitations to the DWI approach were apparent; the high diffusion anisotropy in the corpus callosum made it difficult to compare connection probability values in the adjacent cingulate region.

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Shell and core in monkey and human nucleus accumbens identified with antibodies to calbindin-D28k

Cited by 171 publications

References 81 publications

Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats

Subcellular and subsynaptic localization of group I metabotropic glutamate receptors in the nucleus accumbens of cocaine-treated rats

The Reward Circuit: Linking Primate Anatomy and Human Imaging

Quantitative Investigation of Connections of the Prefrontal Cortex in the Human and Macaque using Probabilistic Diffusion Tractography

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