The structural evolution of the heavy nuclei, with Z > 82, is investigated by looking at the differential variation of the two-neutron separation energies. It indicates, by non-monotonous behavior at certain neutron numbers, structure phenomena such as major shell (N = 126) and deformed subshell (N = 152) closures. Another interesting effect is observed at N ∼ 142, which is very well correlated with a previously observed, intriguing behavior of quantities measured in alpha decay, such as relative branching ratios and hindrance factors of excited states from the ground state band of deformed nuclei in this region. Corroboration of the existing experimental data indicates another possible deformed subshell closure.