Shellfish Allergy: Unmet Needs in Diagnosis and Treatment

Gelis, S; Rueda, M; Valero, Antonio; Fernandez, Eva Abel; Moran, Mirian; Fernández-Caldas, E

doi:10.18176/jiaci.0565

Cited by 32 publications

(28 citation statements)

References 73 publications

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“…[2][3][4] Tropomyosin [45][46][47][48] and arginine kinase 27,32,[49][50][51] have been previously identified as cross-reactive pan-allergens in invertebrates that are associated with allergy to various shellfish. [52][53][54][55][56] Detailed analysis of IgE reactivities to tropomyosins [43][44][45][46] and arginine kinases showed more than 50% IgE positivity for both allergens in the HK cohort (Table II), with a strong correlation between IgE levels to the respective allergens from different species (Fig 4). The high prevalence of positivity to these panallergens in the HK cohort might be due to the frequent consumption of shellfish in this region, but also to common respiratory exposure to tropomyosins and arginine kinases from HDM.…”

Section: Discussionmentioning

confidence: 99%

IgE reactivity patterns in Asian and central European cockroach-sensitized patients reveal differences in primary sensitizing allergen sources

Mittermann¹,

Lupinek²,

Wieser³

et al. 2022

Journal of Allergy and Clinical Immunology: Global

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Section: Discussionmentioning

confidence: 99%

IgE reactivity patterns in Asian and central European cockroach-sensitized patients reveal differences in primary sensitizing allergen sources

Mittermann¹,

Lupinek²,

Wieser³

et al. 2022

Journal of Allergy and Clinical Immunology: Global

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“…3). This approach could help to respond unmet needs in the diagnosis and treatment of patients with shrimp allergy [23]. Additionally, several allergens other than tropomyosin have been found to cross-react to shrimps and HDM [11,24] and should be included in future studies.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Clinical Relevance of Shrimp Sensitization in Patients with Allergic Rhinitis: Anti-Der p 10 IgE as Predictor

Díez¹,

Puerta²,

Martínez³

et al. 2021

Int Arch Allergy Immunol

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Introduction: Cross-reactivity between shrimp and house dust mite (HDM) proteins has been widely documented. In tropical region, shrimp (5–15%) and mite sensitization (80–95%) is prevalent in allergic patients. However, the clinical relevance of shrimp sensitization in patients with allergic rhinitis (AR) has been poorly studied. The aim of this study was to determine the prevalence and the clinical relevance shrimp IgE sensitization in AR patients sensitized to Dermatophagoides pteronyssinus. Methods: The study was conducted in Medellin (Colombia). A cross-sectional study in patients with AR sensitized to HDM was performed in 3 steps: (i) assessment of IgE sensitization frequency to shrimp Penaeus azteca, Litopenaeus vannamei, and tropomyosin homologous allergens rDer p 10, rPen a 1, and rLit v 1, (ii) evaluation of the clinical relevance of shrimp sensitization using oral challenge test (OCT) and (iii) identification of possible risk factors for positive-OCT results. Ethical committee approval was obtained. Results: From 443 patients with AR, 86 (19.4%) were sensitized to shrimp and 23 of them (26.7%) had shrimp allergy diagnosis. Thirty-six of the patients sensitized to shrimp (41.2%) reported not previously consumed this food and eleven of them had a positive-OCT (30.5%). There was not statistically significant difference in total IgE or sIgE (D. pteronyssinus, P. azteca, L. vannamei, rPen a 1, and rLit v 1) between OCT groups (positive vs. negative results). Anti-Der p 10 IgE was associated with risk for a positive-OCT in different multivariable scenarios. Discussion/Conclusion: Our results suggest that in patients with HDM-associated AR and shrimp IgE sensitization is necessary to evaluate the clinical relevance of shrimp IgE even if the patient has never consumed shrimp because of cross-reactivity. Anti-Der p 10 could be a possible biomarker of clinical relevance to shrimp sensitization and could reduce the need for OCTs.

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“…but need to be confirmed in future molecular studies. 9,10 The presence of Southeast Asian Black tiger shrimp sIgE has been established and quantified through ImmunoCAP™ ISAC™ testing, with over 50% of patients having binding to TM, 33% to SCP, 27% to AK, and 13% each to MLC and troponin C. 6 Nevertheless, each individual patient's binding pattern in our study was similar between the two species, both unheated/raw (Figure 1A,B Asian Black tiger in US shrimp allergic subjects, implicating shared diagnostic and therapeutic potential for SA to varied shrimp species.…”

Section: Analys Is Of Allerg En -Sigementioning

confidence: 99%

Similar IgE binding patterns in Gulf of Mexico and Southeast Asian shrimp species in US shrimp allergic patients

Anvari

Brunner

Tuano

et al. 2022

Allergy

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Shellfish Allergy: Unmet Needs in Diagnosis and Treatment

Abstract: This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 32 publications

References 73 publications

IgE reactivity patterns in Asian and central European cockroach-sensitized patients reveal differences in primary sensitizing allergen sources

IgE reactivity patterns in Asian and central European cockroach-sensitized patients reveal differences in primary sensitizing allergen sources

Clinical Relevance of Shrimp Sensitization in Patients with Allergic Rhinitis: Anti-Der p 10 IgE as Predictor

Similar IgE binding patterns in Gulf of Mexico and Southeast Asian shrimp species in US shrimp allergic patients

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