Shengjing Runchang Decoction ameliorates spleen deficiency-induced constipation in children: An observational study

Abstract

Traditional Chinese medicines (TCM) are often used for the treatment of spleen-deficiency (SD) syndrome in China. This study evaluated the curative effects of TCM Shengjing Runchang Decoction on SD-induced constipation children. From July 2019 to April 2020, a total of 70 children with constipation due to spleen deficiency who were admitted to our hospital were selected and randomly divided into control group (n = 35) and treatment group (n = 35). Both groups were treated with standard western medicine, and the treatment group was combined with TCM Shengjing Runchang Decoction at the same time. The clinical efficacy and neurocytokines including 5-hydroxytryptamine (5-HT), vasoactive intestinal peptide (VIP), children’s colonic transit time (CTT), glial cell line-derived neurotrophic factor, colonic estrogen receptor before and after treatment were analyzed and compared between the 2 groups. The curative effect, total effective rate of TCM syndromes, CTT, 5-HT and plasma VIP levels, glial cell-derived nerve effects of trophic factor levels, immune function IgG, IgGA, CD4/CD8 in the treatment group were significantly promoted in comparison with the control group ( P > .05). The TCM Shengjing Runchang Decoction is effective in treatment with children with SD-induced constipation, which can effectively improve immune function, reduce neurotrophic factor secretion and maintain normal secretion and improve colonic motor function.

The synergistic effect of herbal medicine and probiotics in pediatric functional constipation: A systematic review and meta-analysis

“…The illness duration varied, with the shortest duration being 2.19 ± 0.97 (mean ± SD) months, while the longest duration was 15.25 ± 4.00 months (Table 2). Participants were diagnosed using the Rome II, [39] III, [20,22,28,36,37,39] IV, [18,19,21,24,26,29] other published criteria or guidelines, [23,25,[31][32][33][34]38] and using the authors' definitions. [27,30,35]…”

“…HM was administered orally in 22 of the included studies. The formulations employed consisted of decoctions, [18,[22][23][24][25][26]29,31,33,35,38] capsules, [19,28,36] oral solutions, [20,34,37,39] granules, [21,30,32] and pills. [27] The compositions, dosages, and frequencies are listed in Table 3.…”

“…The probiotics used included a mixture of 3 probiotics (Bifidobacterium longum, Lactobacillus bulgaricus, and Streptococcus thermophilus), [18,28,35] another mixture of 3 probiotics (Bifidobacterium, Lactobacillus acidophilus, and Enterococcus faecalis), [19,21,25,26,30] Bifidobacterium quadruple viable tablets (Bifidobacterium infantis, L acidophilus, E faecalis, and Bacillus cereus), [24,34] Clostridium butyricum and Bifidobacterium, [20,23,38] Bacillus subtilis and Enterococcus faecium granules, [22,27,[31][32][33] Saccharomyces boulardii, [36,37] C butyricum, [39] and live Bacillus coagulans tablets. [29] Dosages and frequencies are listed in Table 3.…”

“…[18,19,[21][22][23][24][25][26][27][28]30,32,39] Each study employed various symptom scoring criteria, and selected an analyzable Traditional Chinese Medicine symptom score from among them. [18,22,24,26,37] For studies using the Bristol fecal score, which ranges from 1 to 7, with lower scores indicating severe constipation, 2 studies [28,36] were excluded from the meta-analysis due to outcome errors and 1 study [25] did not report scoring criteria, and 2 studies [19,23] excluded the use of the modified Bristol fecal score. Consequently, 4 studies [26,27,29,30] were included in the analysis.…”

“…Defecation frequency per week was reported in 4 studies [23,26,29,30] and defecation time (the time it takes to have a bowel movement in minutes) was reported in 2 studies. [22,29] www.md-journal.com Regarding secondary outcomes, adverse events were reported in 12 studies, [18,19,22,24,26,28,29,32,[34][35][36]38] and recurrence rates in 11 studies. [18,23,26,28,[33][34][35][36][37][38][39] The recurrence rate was assessed at 2 weeks, [18] 4 weeks, [28,36] 8 weeks, [23] 3 months, [26,34,36,38] and 6 months [37,39] after treatment.…”