Shengxuening Extracted from Silkworm Excrement Mitigates Myelosuppression via SCF‐Mediated JAK2/STAT3 Signaling

Abstract

Shengxuening (SXN) is a Chinese patent medicine with main ingredients (including chlorophyll derivatives and sodium iron chlorophyllin) extracted from silkworm excrement. SXN exhibited efficacy in clinical trials of renal anemia and iron deficiency anemia; however, the specific mechanisms remain unclear. This study found that SXN increased the number of peripheral blood cells and improved the bone marrow morphology in myelosuppressed mouse model, reversed the reduction in body weight and spleen indices, and increased the serum levels of erythropoietin and granulocyte‐macrophage colony‐stimulating factor. Quantitative real‐time PCR array and Western blot analysis showed the enhanced expression of stem cell factor (SCF), JAK2, and STAT3 in the liver. These results suggested that SXN promoted the recovery of hemopoietic function in myelosuppressed models by increasing the secretion of hematopoietic factors and activating the JAK2/STAT3 pathway. Therefore, this medicine may be applied as therapeutic pharmaceutical drug to mitigate myelosuppression.

The efficiency and safety of Shengxuening tablet on treating and preventing iron deficiency anemia: A systematic review and meta-analysis

“…Studies have demonstrated that SXN increased the synthesis of erythropoietin in rats, thereby ameliorating renal anemia in the animals ( Mei et al, 2021 ). Furthermore, SXN promoted the restoration of hemopoietic function in models of myelosuppression by enhancing the secretion of hematopoietic factors and activating the JAK2/STAT3 pathway ( Ding et al, 2021 ). Moreover, another study reported that SXN could also significantly upregulate the expression of granulocyte macrophage colony stimulating factor and stem cell factor in bone marrow cells, thereby alleviating cyclophosphamide-mediated myelosuppression ( Huang et al, 2016 ).…”

Efficacy and Safety of Shengxuening Combined with Conventional Iron Supplementation in the Treatment of Anemia during Pregnancy: A Systematic Review and Meta-analysis

“…It has been found that Shengxuening attenuates myelosuppression, increases bone marrow CFU-E and CFU-GM production, increases reticulocyte percentage, and restores hematopoiesis in a hemorrhagic anemia model through the stem cell factor-mediated JAK2/STAT3 signaling pathway [20,31].…”

A facile and scalable strategy for fabricating bio-based photodynamic antimicrobial nonwoven eco-textiles

“…17 Silkworm excrement is a typical waste product of the mulberry industry, and the active ingredient contains a considerable amount of chlorophyll derivatives. 18,19 Although photodynamic studies of silkworm excrement were rarely performed, researchers had reported the photodynamic behavior of chlorophyll derivatives extracted from other substances. For example, PAA hydrogels containing seaweed extracts and F127 micelles encapsulating chlorophyll derived from green vegetables both exhibited vigorous photodynamic activity and photostability.…”