Shenqi Yizhi Granule attenuates Aβ1–42 induced cognitive dysfunction via inhibiting JAK2/STAT3 activated astrocyte reactivity

Li, Ping; Qian, Wei; Li, Xiaoqiong; Hu, Bangyan; Wen, Wen; Xu, Shijun

doi:10.1016/j.exger.2021.111400

Cited by 6 publications

(3 citation statements)

References 67 publications

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“…SQYG treatment exhibited significant neuroprotective effects on the hippocampus of 5XFAD mice through modulating multiple pathological processes, such as synaptic transmission, signal transduction, and amino acid metabolism ( Ren et al, 2020 ). Other relevant mechanisms involve inhibiting response of astrocytes regulated by the JAK2/STAT3 signaling pathway, which has been proven in an Aβ 1-42 -induced rat model of AD ( Li P. et al, 2021 ). Other possible molecular mechanisms of SQYG were investigated through an integration strategy of network pharmacology and molecular docking.…”

Section: Herbal Medicine and Admentioning

confidence: 99%

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu,

Li,

Liang

et al. 2024

Front. Pharmacol.

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Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and cognitive impairment. It severely affects the quality of life of victims. The prevalence of AD has been increasing in recent years. Therefore, it is of great importance to elucidate the pathogenic mechanism of AD and search for effective therapeutic approaches. Gut microbiota dysbiosis, an altered state of gut microbiota, has been well known for its involvement in the pathogenesis of AD. Much effort has been made in searching for approaches capable of modulating the composition of gut microbiota in recent years. Herbal medicines have attracted extensive attention in recent decades for the prevention and treatment of AD. Here, we gave an overview of the recent research progress on the modulatory effects of herbal medicines and herbal formulae on gut microbiota as well as the possible beneficial effects on AD, which may provide new insights into the discovery of anti-AD agents and their therapeutic potential for AD through modulating the composition of gut microbiota.

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Section: Herbal Medicine and Admentioning

confidence: 99%

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Liu,

Li,

Liang

et al. 2024

Front. Pharmacol.

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“…Bunge, Scutellaria baicalensis Georgi, Salvia miltiorrhiza Bunge, and Alisma plantago-aquatica L with a ratio of 2 : 4 : 3 : 3 : 2. The main active compounds of SQYG included ginsenoside Rb1, ginsenoside Rg1, ginsenoside Rd, baicalin, cryptotanshinone, and tanshinone IIA [ 10 ]. These active compounds have a wide range of activities, including neuron cells protection, synaptoprotective effect, antioxidation, promoting energy metabolism, anti-inflammation, lipid composition regulation, and metal ion homeostasis, which are all key points in AD therapy [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies have shown that SQYG ameliorated the cognitive impairments in APP/PS1 mice by inhibiting neuronal loss, soluble A β deposition, tau hyperphosphorylation, and inflammation [ 14 ]. The hippocampus of 5XFAD transgenic mice treated with SQYG presented fewer A β deposits and reduced A β 1–42 levels [ 10 ]. The neuroprotective mechanisms of SQYG on the hippocampus of 5XFAD mice were related to modulation of multiple pathological processes, including energy metabolism, stress response, cytoskeleton, synaptic transmission, signal transduction, and amino acid metabolism [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer’s Disease

Wang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Traditional Chinese herbal medicine draws more attention to explore an effective therapeutic strategy for Alzheimer’s disease (AD). Shenqi Yizhi granule (SQYG), a Chinese herbal recipe, has been applied to ameliorate cognitive impairment in mild-to-moderate AD patients. However, the overall molecular mechanism of SQYG in treating AD has not been clarified. Objective. This study aimed to investigate the molecular mechanism of SQYG on AD using an integration strategy of network pharmacology and molecular docking. Methods. The active compounds of SQYG and common targets between SQYG and AD were screened from databases. The herb-compound network, compound-target network, and protein-protein interaction network were constructed. The enrichment analysis of common targets and molecular docking were performed. Results. 816 compounds and 307 common targets between SQYG and AD were screened. KEGG analysis revealed that common targets were mainly enriched in lipid metabolism, metal ion metabolism, IL-17 signaling pathway, GABA receptor signaling, and neuroactive ligand-receptor interaction. Molecular docking analysis showed high binding affinity between ginsenoside Rg1 and Aβ1–42, tanshinone IIA and BACE1, baicalin, and AchE. Conclusions. The therapeutic mechanisms of SQYG on AD were associated with regulating lipid metabolism, metal ion metabolism, IL-17 signaling pathway, and GABA receptor signaling. Ginsenoside Rg1, tanshinone IIA, baicalin, astragaloside IV, and folic acid may play an important role in AD treatment.

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Targeting STAT3 signaling pathway in the treatment of Alzheimer’s disease with compounds from natural products

Wen,

2024

International Immunopharmacology

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Shenqi Yizhi Granule attenuates Aβ1–42 induced cognitive dysfunction via inhibiting JAK2/STAT3 activated astrocyte reactivity

Cited by 6 publications

References 67 publications

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Herbal medicines in Alzheimer’s disease and the involvement of gut microbiota

Network Pharmacology and Molecular Docking-Based Strategy to Investigate the Multitarget Mechanisms of Shenqi Yizhi Granule on Alzheimer’s Disease

Targeting STAT3 signaling pathway in the treatment of Alzheimer’s disease with compounds from natural products

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