Shift in Viral Strains of Hepatitis B in Stockholm as Reflected by Subtypes of Hepatitis B Antigen

Magnius, Lars O.; Berg, Rebekka; Bjorvatn, Bjarne; Svedmyr, Arne

doi:10.3109/inf.1973.5.issue-2.01

Cited by 29 publications

(9 citation statements)

References 12 publications

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“…This study by Chattopadhyay et al also adds the significant clinical information that HBV genotype D is the dominant genotype in patients with HBV-related acute and fulminant hepatitis, and even in asymptomatic HBsAg carriers when compared to genotype A. This is in agreement with the previous reports form Europe [24][25][26] with regard to HBV genotype D-induced acute hepatitis, while the high prevalence of HBV genotype B in HBV-related acute hepatitis has been reported form Japan [27]. Thus, there is a difference in the ability to induce acute hepatitis among HBV genotypes, and therefore, further epidemiological studies should be completed at a worldwide range for understanding of causal relationship between HBV genotypes and acute liver diseases.…”

supporting

confidence: 92%

“…There have previously been similar reports from Japan that HBV genotype A more often progresses to chronicitythan genotypes B and C [28][29][30]. In an earlier period, a high prevalence of HBsAg serotype adw (prevailed HBV genotype A) has been found in patients with HBV-related chronic hepatitis, while HBsAg serotype ayw (prevailed HBV genotype D) is prevalent in those with HBV-related acute hepatitis [24][25][26]. Taken together, it is likely that HBV genotypes somehow correlate to the chronicity of HBV infection, whereas the correlation between such a chronicity and the severity of liver disease is still inconclusive.…”

mentioning

confidence: 82%

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Is the genotyping of hepatitis B virus of clinical help in patient management?

Tazuma¹

2006

Hepatology Research

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supporting

confidence: 92%

mentioning

confidence: 82%

Is the genotyping of hepatitis B virus of clinical help in patient management?

Tazuma¹

2006

Hepatology Research

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“…The B, C and D groups of HBV genomes appear to have arisen in regions of the world that were among the first to become densely populated, and might at present be spreading into areas where previously other HBV strains have dominated. A shift in the prevailing HBV strain with time as reflected by subtype has been reported in Sweden (Magnius et al, 1973). The south to north gradient in the distribution of the adr subtype in Japan also provides evidence for such a change (Yamashita et al, 1976).…”

Section: Discussionmentioning

confidence: 71%

Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen

Nordér

Hammas

Lee

et al. 1993

Journal of General Virology

319

292

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A 681 nucleotide fragment of the hepatitis B virus (HBV) genome was sequenced that corresponded to the complete gene for hepatitis B surface antigen (HBsAg) in 80HBsAg-and hepatitis B e antigen (HBeAg)-positive sera of diverse geographical origins. These and 42 previously published HBV sequences within the S gene were used for the construction of a dendrogram. In this comparison, each of the 122 HBsAg genes was found to be related to one or other of the six previously identified genomic groups of HBV, A to F. The HBV strains within each genomic group showed a characteristic geographical distribution. Group A genomes were represented by 23 strains mainly originating in northern Europe and sub-Saharan Africa. The group B and C genomes, represented by 17 and 28 strains respectively, were confined to populations with origins in eastern Asia and the Far East. The group D genomes, represented by 38 strains, were found worldwide, but were the predominant strains in the Mediterranean area, the Near and Middle East, and in south Asia. Group E genomes, represented by nine strains, were indigenous to western sub-Saharan Africa as far south as Angola. There were indications that the F group, made up of six strains, represented the genomic group of HBV among populations with origins in the New World. Thus, HBV has diverged into genomic groups according to the distribution of mankind in the different continents. As well as giving information on the genetic relationship of HBV strains of different geographical origin, this study also provides information on the primary structure of HBsAg in different regions of the world. Such data might prove valuable in explaining the reported failures to obtain protection with current HBV vaccines.

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“…The spread of subtype ayw might have been affected by a specific factor not acting on the other three subtypes. Of possible relevance to this is an epidemic spread of HBV subtype ayw among drug abusers (Magnius et al, 1973;Nielsen et al, 1973).…”

Section: Discussionmentioning

confidence: 99%

Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes

Okamoto

Tsuda

Sakugawa

et al. 1988

Journal of General Virology

950

774

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SUMMARYThe complete nucleotide sequences of the DNA of three hepatitis B virus (HBV) genomes of subtype adw, cloned from plasma samples of asymptomatic carriers living in the mainland and Okinawa Prefecture of Japan and Indonesia were determined. All three comprised 3215 bp and differed in sequence by only 3.9 to 5.6%. When these isolates were compared with the reported sequences of two HBV genomes of the same subtype derived from American carriers, however, the differences were greater (8.3 to 9.3%) to an extent comparable with the nucleotide divergence between an HBV genome of subtype adw and that of a heterotypic subtype, such as adr, ayw or ayr. A total of 18 HBV genomes of various subtypes, including the three described here, 10 reported previously and five unpublished ones, were classified into four groups based on an inter-group divergence in nucleotide sequence of 8 ~o or greater: group A (two adw genomes), group B (four adw), group C (three adw, four adr and one ayr) and group D (four ayw). Thus, the nine genomes of HBV subtype adw were distributed into three groups with considerably different sequences. These results indicate that the four major antigenically defined subtypes of envelope polypeptide do not reflect true genotypic variation of HBV. The fact that dtoy, as well as w to r, subtypic change can be induced by an A --, G point mutation at nucleotides 365 and 479 in the S gene, respectively, supports this view.

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Shift in Viral Strains of Hepatitis B in Stockholm as Reflected by Subtypes of Hepatitis B Antigen

Cited by 29 publications

References 12 publications

Is the genotyping of hepatitis B virus of clinical help in patient management?

Is the genotyping of hepatitis B virus of clinical help in patient management?

Genetic relatedness of hepatitis B viral strains of diverse geographical origin and natural variations in the primary structure of the surface antigen

Typing Hepatitis B Virus by Homology in Nucleotide Sequence: Comparison of Surface Antigen Subtypes

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