Shift of oxidants and antioxidants levels in rats as a reaction to exposure to sulfur mustard

Abstract

Antixodants as well as oxidants levels were investigated in plasma of rats exposed to sulfur mustard in doses of 0 (control), 5, 20 and 80 mg kg(-1) body weight. Cyclic voltammetry performed on screen-printed strips with platinum working electrode used as a tool for assaying oxidant and antioxidant levels. We found significant shifts in both examined analytes. A dose of sulfur mustard of 5 mg kg(-1) body weight caused only a small change in oxidant and antioxidant levels when compared with the control group. A dose of 20 mg kg(-1) body weight provided a significant increase in antioxidants as well oxidants; however, the ratio of both was similar to that in the control group. The most surprising facts were found when the highest dose of 80 mg kg(-1) body weight of sulfur mustard was applied. While antioxidants were significantly increased, oxidants were decreased on an extensive scale.

Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin

“…Oxidative stress is one of the most studied mechanisms in SM-induced skin injury (Han et al , 2004; Pal et al , 2009; Pohanka and Stetina, 2009; Laskin et al , 2010). Our previous studies have shown that oxidative stress plays an important role in the activation of complex signaling pathways that lead to CEES-caused skin injury (Pal et al , 2009; Tewari-Singh et al , 2010).…”

Evaluation of plasma, erythrocytes, and brochoalveolar lavage fluid antioxidant defense system in sulfur mustard-injured patients

“…[33][34][35] At the first step of the defense system against oxidative stress, superoxide dismutase catalyzes dismutation of the superoxide anion into H 2 O 2 . At the second step of the antioxidant defense system, glutathione peroxidase and catalase independently degrade H 2 O 2 to water.…”

Changes of rat plasma total low molecular weight antioxidant level after tabun exposure and consequent treatment by acetylcholinesterase reactivators

“…In contrast to the previous experiments, equimolar doses of oximes were administered into the animals. All the drugs were selected from previous studies as being potent AChE reactivators in vitro; obidoxime, trimedoxime and HI-6 are currently available in many countries including NATO members [13][14][15]. Their potency to reactivate AChE was evaluated by in vitro studies and seemed to be sufficient [16].…”

“…An increase of LMWA is associated with stress that may arise in non-pathological conditions [21]. Healthy organisms are able to protect themselves even when they are exposed to high doses of toxic compounds such as sulphur mustard [13]. Oxidative stress arises when an organism is insufficiently protected and this can occur shortly after a toxicity burden [22,23].…”