Shift of the 2009–2011 measles outbreak from children to adults: an observational review at the University Hospital of Clermont-Ferrand, France

Abstract

In 2009-2011, 113 adult in- and outpatients with measles were referred to the University Hospital of Clermont-Ferrand (centre of France): 71 (62.8 %) needed hospitalisation, 31 had pneumonia, 29 diarrhoea, 47 liver enzymes elevation, 38 thrombopaenia, one encephalitis and there were no deaths. Nineteen cases occurred among healthcare workers and five of them were hospital-acquired. There were 92 unvaccinated patients. The 2011 peak of that measles re-emerging epidemic occurred when non-immunised adults were affected.

Measles in adults during an outbreak in Spain: hospitalization associated with gastrointestinal and liver involvement

“…In our study, the hepatic dysfunction occurred from initial stages, even in patients with limited rash and systemic manifestations, and it was asymptomatic. Liver involvement was associated with hospitalization of patients as in a previous report [9]. In our series, the prognosis of measles in adults was excellent overall.…”

“…The prevalence of hepatitis has been shown to vary from none to 89 % [1,9,10]. In our study, the hepatic dysfunction occurred from initial stages, even in patients with limited rash and systemic manifestations, and it was asymptomatic.…”

Evaluation of Measles Cases in Adults

“…Çeşitli çalış-malarda lökopeni % 11.2-% 73 (1,7,11) , trombositopeni ise % 33.6-% 50 oranında saptanmıştır (6,11) . Bizim çalışmamızda hastaların 13'ünde (% 68.4) lökopeni, üçünde (% 15.7) trombositopeni tespit edilmiştir.…”

Immune Response to the Mumps Virus in Iranian Unvaccinated Young Adults

“…It is administered as 2 doses of the measles, mumps, and rubella (MMR) vaccine, at 12 and 18 months of age (4). Mumps is endemic in Iran and low immunity against mumps in Iranian adults, due to the absence of MMR vaccine before 2003, is a result of natural infection.…”