Shift of uterine microbiota associated with antibiotic treatment and cure of metritis in dairy cows

Lima, F.S.; Vieira-Neto, A.; Machado, V.S.; Lima, Svetlana; Santos, J.E.P.; Galvão, Klibs N.

doi:10.1016/j.vetmic.2017.12.022

Cited by 42 publications

(56 citation statements)

References 38 publications

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“…The potential role of antibiotics to alter the microbiome of the reproductive tract is currently uncertain and needs further investigation (28). Antibiotic use has been found to be effective in women for decreasing colonization of the vagina by pathogenic species; however, the treatment did not successfully alter the clinical outcomes associated with NLD vaginal microbiota associated with preterm birth or pregnancy rates in IVF treatments (6).…”

Section: Future Directions For Investigating the Female Reproductive mentioning

confidence: 99%

Role for the mammalian female reproductive tract microbiome in pregnancy outcomes

Heil

Paccamonti

Sones

2019

Physiological Genomics

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Since the discovery of the microbiome in humans, it has been studied in many mammalian species. Different microbiological communities with variable richness and diversity have been found among these species in distinct areas of the reproductive tract. Human studies have shown that the composition of the microbiome is dependent on body site and several host-related factors. Furthermore, specific phyla have been identified among the different species and within distinct areas of the female reproductive tract, but a “core” microbiome of the female reproductive tract has not been defined in any species. Moreover, the function of the microbiome in the reproductive tract is not yet fully understood. However, it has been suggested that a change in diversity of the microbiome and the presence or absence of specific microbial species might be useful indicators of pregnancy outcomes. Increased comprehensive knowledge of the microbiological communities in the female reproductive tract is needed since adverse outcomes represent a significant problem to many species, including livestock, exotic or endangered species, and humans. To the authors’ knowledge, a review combining current female reproductive tract microbiome data among different mammalian species has not been published yet. Herein is a comprehensive review of what is known in the field of the female reproductive microbiome and how it correlates with reproductive success or failure in mammals. Further studies may lead to optimization of therapies in the treatment of reproductive tract infections and pregnancy failure, and may create opportunities for novel approaches for improving reproductive efficiency in animals and people.

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Section: Future Directions For Investigating the Female Reproductive mentioning

confidence: 99%

Role for the mammalian female reproductive tract microbiome in pregnancy outcomes

Heil

Paccamonti

Sones

2019

Physiological Genomics

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“…Uterine swabs from ceftiofurtreated, ampicillintreated, and un treated PM cows were taken on the day of diagnosis and 6 days after treatment to study the changes in uterine microbiota. Bacteroide tes was increased in ceftiofurtreated cows but was not changed in ampicillintreated and untreated cows; Porphyromonas was in creased in ceftiofurtreated cows but was not in ampicillintreat ed cows; and failure to cure PM was associated with a decrease in the diversity of uterine microbiota and an increase in the relative abundance of Bacteroides, Porphyromonas and Fusobacterium spe cies [39]. It is noteworthy to point out that cows, that after calv ing progress to PM, have a shift in uterine microbiota, decreasing the abundance of Proteobacteria and increasing the abundance of Bacteroidetes and Fusobacteria [39].…”

Section: Discussionmentioning

confidence: 93%

“…Fur thermore, one cow with PM had had both genes associated with specific drug resistance for T. pyogenes and genes of E. coli biofilm VF. More recently, the shift of uterine microbiota associated with ATB treatment and the cure of PM in dairy cows was studied [39]. Uterine swabs from ceftiofurtreated, ampicillintreated, and un treated PM cows were taken on the day of diagnosis and 6 days after treatment to study the changes in uterine microbiota.…”

Section: Discussionmentioning

confidence: 99%

Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina

Sota

Corva²,

Domínguez³

et al. 2020

Tierarztl Prax Ausg G Grosstiere Nutztiere

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Objective To assess the efficacy of antibiotic usage for the treatment of puerperal metritis (PM) and its association with reproductive performance, a retrospective cohort study including a total of 9168 records of cows from a dairy farm in Argentina was run. Material and methods Cows having a PM3 (metricheck, scale 0–3) and treated with ceftiofur (ceftiofur crystalline free acid, 6.6 mg/kg) at 0–21 days postpartum (p. p.) (n = 2688), and cows having a PM 1–2 and not treated with an antibiotic at 0–21 days p. p. (n = 6480) were included in the study. All cows were reexamined with metricheck to assess the clinical cure (vaginal discharge [VD] score 0), partial cure (VD score similar or lower than previous), no cure (VD score higher than previous). Cows with a metricheck VD1–3 after 0–21 days p. p. were diagnosed as clinical endometritis (CE) 1–3. The occurrence of PM1–3, cure rate, calving to conception interval, the hazard of pregnancy, odds for non-pregnancy, and odds for CE were analyzed using SAS software. Results A total of 8876 PM1–3 records were included, 2435 records of PM3 treatments with ceftiofur (27.43 %), and 6441 records of PM1–2 (72.57 %) with no treatment. Cows having PM1 and PM2 became pregnant 14 and 12 days earlier than cows with PM3 (p < 0.001). The PM3 ceftiofur treated cows had a clinical cure of 24.85 % (PM0); 53.63 % had a partially cure; and 18.52 % no cure. Conversely, cows with PM1–2 had a 51.96 %, 20.70 %, and 24.53 % cure rate, respectively (p < 0.001). Cows having complete cure became pregnant 13 and 11 days earlier than cows having partial cure and no cure (p < 0.001). Cows that had PM3 during the first 21 days p. p. had twice the chances of developing CE compared to cows having PM1–2 (41.28 % vs. 24.14 %, p < 0.001). After 21 days p. p., less than 1 % of cows with clinical cure developed CE compared to 63.32 % that developed CE with partial cure, and 38.21 % with no cure (p < 0.001). Conclusion and clinical relevance After ceftiofur treatment, 78 % of cows were cured when measured by disappearance of fetid VD but only 25 % of cows had clinical cure when measured by appearance of a clear VD. The cows that remained with clinical metritis had more chances of having CE after 21 days p. p. and had more days open than cows with clear normal VD.

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“…Uterine microbiota may also be crucial in protection against uterine infections by defending their niche and competing with pathogens (Benner et al, 2018). In dairy cows, the uterine microbiome of healthy and metritic cows has been characterized and indicates distinct compositional signatures that affect the ability of cure from the disease (Galvão et al, 2019a;Jeon et al, 2018).…”

Section: Advances On Understanding Of Uterine Diseases Pathogenesismentioning

confidence: 99%

“…On the other hand, a myriad of research advances shed light on how uterine diseases may disrupt endocrine signaling, oocyte, follicle and embryo development, and the uterine environment ( Bromfield et al., 2015 ; Horlock et al., 2020 ; Moore et al., 2019 ; Piersanti et al., 2019 ; Ribeiro, 2018 ). The understanding of uterine diseases microbiome also had tremendous progress and created opportunities for the development of novel preventives to improve the management of uterine diseases ( Bicalho et al., 2012 ; Freick et al., 2017 ; Galvão et al., 2019a ; Jeon et al., 2018 ; Machado et al., 2014 ; Sheldon et al., 2010 ). Indeed, in the last decade, over a dozen of non-antimicrobial therapeutics to prevent and treat metritis and endometritis has been investigated with encouraging results ( Ahmadi et al., 2019 ; Ametaj et al., 2014 ; ATLAS Collaboration, 2017 ; Brick et al., 2012 ; Daetz et al., 2016 ; Escandon et al., 2020 ; Genis et al., 2018 ; Machado et al., 2012 ; Pinedo et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Recent advances and future directions for uterine diseases diagnosis, pathogenesis, and management in dairy cows

Lima

2020

Anim. Reprod.

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Shift of uterine microbiota associated with antibiotic treatment and cure of metritis in dairy cows

Cited by 42 publications

References 38 publications

Role for the mammalian female reproductive tract microbiome in pregnancy outcomes

Role for the mammalian female reproductive tract microbiome in pregnancy outcomes

Analysis of puerperal metritis treatment records in a grazing dairy farm in Argentina

Recent advances and future directions for uterine diseases diagnosis, pathogenesis, and management in dairy cows

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