2020
DOI: 10.1101/2020.08.11.245555
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Shiga toxin remodels the intestinal epithelial transcriptional response to Enterohemorrhagic Escherichia coli

Abstract: Enterohemorrhagic Escherichia coli (EHEC) is a food-borne pathogen that causes diarrheal disease and the potentially lethal hemolytic uremic syndrome. We used an infant rabbit model of EHEC infection that recapitulates many aspects of human intestinal disease to comprehensively assess colonic transcriptional responses to this pathogen. Cellular compartment-specific RNA-sequencing of intestinal tissue from animals infected with EHEC strains containing or lacking Shiga toxins (Stx) revealed that EHEC infection e… Show more

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(1 citation statement)
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“…NleF, as a non-LEE effector, is considered a prominent virulence factor because of counteraction to the host inflammatory response and inhibition of cell death. Several non-LEE-effectors such as NleB, NleE, BleG, NleH, and EspJ have been recently shown to mediate EHEC survival and biofilm formation (Table) [52][53][54].…”
Section: Enterohaemorrhagic Escherichia Coli (Ehec)mentioning
confidence: 99%
“…NleF, as a non-LEE effector, is considered a prominent virulence factor because of counteraction to the host inflammatory response and inhibition of cell death. Several non-LEE-effectors such as NleB, NleE, BleG, NleH, and EspJ have been recently shown to mediate EHEC survival and biofilm formation (Table) [52][53][54].…”
Section: Enterohaemorrhagic Escherichia Coli (Ehec)mentioning
confidence: 99%