Shikonin ameliorates cerulein-induced acute pancreatitis in mice

Xiong, Jie; Ni, Jiahua; Hu, Guoyong; Shen, Jie; Zhao, Yan; Yang, Lijuan; Shen, Jiaqing; Guo, Yin; Chen, Congying; Yu, Ge; Hu, Yanling; Xing, Miao; Wan, Rong; Wang, Xingpeng

doi:10.1016/j.jep.2012.11.032

Cited by 35 publications

(23 citation statements)

References 29 publications

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“…The apoptosis of pancreatic acinar cells is initiated as a response for inflammation related stimulation to the cells (Xiong et al 2013). Also, the apoptosis and necrosis of pancreatic acinar cells have reciprocal transformation.…”

Section: µMmentioning

confidence: 99%

Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis

Jung

Son

et al. 2014

Arch. Pharm. Res.

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Severe acute pancreatitis (SAP), a common necroinflammatory disease initiated by the premature activation of digestive enzymes within the pancreatic acinar cells, is associated with significant morbidity and mortality. In this study, we investigated whether human bone marrow-derived clonal mesenchymal stem cells (hcMSCs), isolated from human bone marrow aspirate according to our newly established isolation protocol, have potential therapeutic effects in SAP. SAP was induced by three intraperitoneal (i.p.) injections of cerulein (100 μg/kg) and sequential LPS (10 mg/kg) in Sprague-Dawley (SD) rats. hcMSCs (1 × 10(6)/head) were infused on 24 h after LPS injection via the tail vein. The rats were sacrificed 3 days after infusion of hcMSCs. We observed that infused hcMSCs reduced the levels of serum amylase and lipase. Infused hcMSCs ameliorated acinar cell necrosis, pancreatic edema, and inflammatory infiltration. Also, infused hcMSCs decreased the level of malondialdehyde, and increased the levels of glutathione peroxidase and superoxide dismutase. The number of TUNEL positive acinar cells was reduced after hcMSCs infusion. In addition, hcMSCs reduced the expression levels of pro-inflammation mediators and cytokines, and increased the expression of SOX9 in SAP. Taken together, hcMSCs could effectively relieve injury of pancreatitis as a promising therapeutics for SAP.

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Section: µMmentioning

confidence: 99%

Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis

Jung

Son

et al. 2014

Arch. Pharm. Res.

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“…The roots of traditional Chinese medicinal herb Lithospermum erythrorhizon are rich source of shikonin (Figure , Shikonin), which is an active red naphthoquinone compound. The compound is primarily used natural medicine for treating antibacterial, anti‐inflammatory, or antitumor drugs and for inhibition of HIV virus . Recently, the research interests of shikonin have gradually shifted to its derivatives, which further can potentially be used as drugs for cancer.…”

mentioning

confidence: 99%

“…compound. The compound is primarily used natural medicine for treating antibacterial, anti-inflammatory, or antitumor drugs and for inhibition of HIV virus (1)(2)(3)(4)(5)(6)(7). Recently, the research interests of shikonin have gradually shifted to its derivatives, which further can potentially be used as drugs for cancer.…”

mentioning

confidence: 99%

Synthesis and Biological Evaluation of Heterocyclic Carboxylic Acyl Shikonin Derivatives

et al. 2013

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A series of shikonin derivatives (1-13) that were acylated selectively by various thiophene or indol carboxylic acids at the side chain of shikonin were synthesized, and their biological activities were also evaluated as potential tubulin inhibitors. Among them, compound 3 ((R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl 3-(1H-indol-3-yl)propanoate) and compound 8 ((R)-1-(5,8-dihydroxy-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-4-methylpent-3-enyl 2-(thiophen-3-yl)acetate) exhibited good antiproliferative activity of A875 (IC50 = 0.005 ± 0.001 μm, 0.009 ± 0.002 μm) and HeLa (IC50 = 11.84 ± 0.64 μm, 4.62 ± 0.31 μm) cancer cell lines in vitro, respectively. Shikonin (IC50 = 0.46 ± 0.002 μm, 4.80 ± 0.48 μm) and colchicine (IC50 = 0.75 ± 0.05 μm, 17.79 ± 0.76 μm) were used as references. Meanwhile, they also showed the most potent growth inhibitory activity against tubulin (IC50 of 3.96 ± 0.13 μm and 3.05 ± 0.30 μm, respectively), which were compared with shikonin (IC50 = 15.20 ± 0.25 μm) and colchicine (IC50 = 3.50 ± 0.35 μm). Furthermore, from the results of flow cytometer, we found compound 3 can really inhibit HeLa cell proliferation and has low cell toxicity. Based on the preliminary results, compound 3 with potent inhibitory activity in tumor growth may be a potential anticancer agent.

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“…In addition, increasing investigations have indicated that TCM formulas offer feasible approaches for treating AP due to their promising effects on inflammatory and pain disorders, abdominal distension and constipation [8,[10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

Jin¹,

Li²,

Song³

et al. 2017

Trop. J. Pharm Res

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Shikonin ameliorates cerulein-induced acute pancreatitis in mice

Cited by 35 publications

References 29 publications

Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis

Therapeutic effect of human clonal bone marrow-derived mesenchymal stem cells in severe acute pancreatitis

Synthesis and Biological Evaluation of Heterocyclic Carboxylic Acyl Shikonin Derivatives

Therapeutic effect of He-Wei-Tong-Xie decoction on acute pancreatitis complicated with gastrointestinal dysfunction

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