Dr. Margaret-Ann Armour was a foundational builder of equity, diversity, and inclusion in Canada. This article describes her vision and leadership in creating the Canadian Centre for Women in Science, Engineering, Trades, and Technology (WinSETT Centre, www.winsett.ca) to generate and sustain national conversations and diversity initiatives. We outline the activities associated with these phases — beginning the diversity initiative, building on success, creating capacity, and launching a national centre — to demonstrate how this change effort has evolved. The comprehensive work since 2003 illustrates the focus, tenacity, and institutional entrepreneurship of Dr. Armour to ‘move the dial’ for diversity and inclusion in Canada. She was a pioneer in social entrepreneurship, creating the organizations, initiatives, and networks to support systemic change.