Shining light on Barrett’s esophagus

Quaroni, Luca; Zhao, Ronghua; Casson, Alan G.

doi:10.1586/egh.09.43

Cited by 5 publications

(3 citation statements)

References 36 publications

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“…In addition, it is important to note that our predictors P1–P3 were not planned a priori and, therefore, the definitions and their results might require validation in an independent study. All predictors might provide an additive opportunity for early intervention and improved outcome in patients with EAC (Reid et al , 2001; Quaroni et al , 2009). …”

Section: Discussionmentioning

confidence: 99%

Multi-colour FISH in oesophageal adenocarcinoma—predictors of prognosis independent of stage and grade

Geppert

Rümmele

Sarbia³

et al. 2014

Br J Cancer

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Background:Oesophageal adenocarcinoma or Barrett's adenocarcinoma (EAC) is increasing in incidence and stratification of prognosis might improve disease management. Multi-colour Fluorescence in situ hybridisation (FISH) investigating ERBB2, MYC, CDKN2A and ZNF217 has recently shown promising results for the diagnosis of dysplasia and cancer using cytological samples.Methods:To identify markers of prognosis we targeted four selected gene loci using multi-colour FISH applied to a tissue microarray containing 130 EAC samples. Prognostic predictors (P1, P2, P3) based on genomic copy numbers of the four loci were statistically assessed to stratify patients according to overall survival in combination with clinical data.Results:The best stratification into favourable and unfavourable prognoses was shown by P1, percentage of cells with less than two ZNF217 signals; P2, percentage of cells with fewer ERBB2- than ZNF217 signals; and P3, overall ratio of ERBB2-/ZNF217 signals. Median survival times for P1 were 32 vs 73 months, 28 vs 73 months for P2; and 27 vs 65 months for P3. Regarding each tumour grade P2 subdivided patients into distinct prognostic groups independently within each grade, with different median survival times of at least 35 months.Conclusions:Cell signal number of the ERBB2 and ZNF217 loci showed independence from tumour stage and differentiation grade. The prognostic value of multi-colour FISH-assays is applicable to EAC and is superior to single markers.

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Section: Discussionmentioning

confidence: 99%

Multi-colour FISH in oesophageal adenocarcinoma—predictors of prognosis independent of stage and grade

Geppert

Rümmele

Sarbia³

et al. 2014

Br J Cancer

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“…The potential of FTIR to provide a rapid, objective and non-destructive histopathological analysis has been recognised for several decades. 125 In part because of the challenges posed by the strong absorption by water in the mid-infrared region, FTIR is less well-suited to use in vivo, and in the oesophagus work has focused on developing a tool as an adjunct to histopathology.…”

Section: In Vivo Feasibilitymentioning

confidence: 99%

Vibrational spectroscopy for cancer diagnostics

et al. 2014

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“…The understanding of Barrett's oesophagus (BO) has improved in recent years, but still much remains unknown [1, 2]. BO would be of little importance if not for its well-recognized association with adenocarcinoma of the oesophagus (ACO) [1, 3].…”

Section: Introductionmentioning

confidence: 99%

Influence of Life Style Factors on Barrett’s Oesophagus

Strand

Franzen

2014

Gastroenterology Research and Practice

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Background. Since the incidence of adenocarcinoma of the oesophagus is rising, the prognosis is poor, and surveillance programs are expensive and mostly cost ineffective, there is a need to increase the knowledge of risk factors in Barrett's oesophagus and oesophageal cancer in order to be able to give attention to medical prevention and/or surveillance programs. Aim. To study if there is a correlation between the development of Barrett's oesophagus and GOR (gastro oesophageal reflux), family history of GOR, and life style factors, such as alcohol, smoking habits, and mental stress. Methods. Fifty-five consecutively selected patients with Barrett's oesophagus (BO) examined at Linköping University Hospital's Oesophageal Laboratory were matched by sex, age, and duration of reflux symptoms with 55 GOR patients without Barrett's oesophagus at the Oesophageal Laboratory. The medical charts in respective groups were examined for comparison of life style factors, mental stress, medication, duration of gastroesophageal acid reflux at 24 hr-pH-metry, and incidence of antireflux surgery and of adenocarcinoma of the oesophagus (ACO). Also, potential gender differences and diagnosis of ACO were studied. Results. Mean percentage reflux time on 24 hr-pH-metry was higher for the Barrett's oesophagus group, 18% for women and 17% for men compared to 4% for women and 4% for men in the control group (P < 0.05). Family history of GOR was more frequent in Barrett's oesophagus patients (62%) than in the control group (35%) (P < 0.05). Male patients with Barrett's oesophagus had medical therapy for their GOR symptoms to a higher extent (38%) than male controls (65%) (P < 0.05). No difference was found in the number of tobacco users or former tobacco users between Barrett's oesophagus patients and controls. Barrett's oesophagus patients had the same level of alcohol consumption and the same average BMI as the control subjects. Female patients with Barrett's oesophagus rated themselves as more mentally stressed (67%) than the female controls (38%) (P < 0.05). In the five-year medical chart follow-up, five of 55 patients developed adenocarcinoma among the Barrett's oesophagus patients, none in the control group. Conclusions. Long reflux time and family clustering of GOR seem to influence the development of Barrett's oesophagus. Smoking habits, alcohol consumption and BMI do not seem to have any impact on the development of Barrett's oesophagus.

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Shining light on Barrett’s esophagus

Abstract: • Preliminary report of the potential for synchrotron FTIR to characterize esophageal stem cell-like cell populations.

Cited by 5 publications

References 36 publications

Multi-colour FISH in oesophageal adenocarcinoma—predictors of prognosis independent of stage and grade

Multi-colour FISH in oesophageal adenocarcinoma—predictors of prognosis independent of stage and grade

Vibrational spectroscopy for cancer diagnostics

Influence of Life Style Factors on Barrett’s Oesophagus

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