2000
DOI: 10.1034/j.1600-0684.2000.290313.x
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SHIV89.6P pathogenicity in cynomolgus monkeys and control of viral replication and disease onset by human immunodeficiency virus type 1 Tat vaccine

Abstract: The Tat protein of human immunodeficiency virus (HIV) is produced very early after infection, plays a key role in the virus life cycle and in acquired immunodeficiency syndrome (AIDS) pathogenesis, is immunogenic and well conserved among all virus clades. Notably, a Tat-specific immune response correlates with non-progression to AIDS. Here, we show that a vaccine based on the Tat protein of HIV blocks primary infection with the simian/human immunodeficiency virus (SHIV)89.6P and prevents the CD4 T cell decline… Show more

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Cited by 53 publications
(44 citation statements)
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“…At each time-point bleedings were performed for routine blood chemistry tests and immunological determinations. The vaccination protocols and schedules have been reported elsewhere [34][35][36]. After 14-18 weeks from the last boost, all animals were challenged intravenously (i.v.)…”
Section: Vaccination Protocol and Virus Challengementioning
confidence: 99%
See 4 more Smart Citations
“…At each time-point bleedings were performed for routine blood chemistry tests and immunological determinations. The vaccination protocols and schedules have been reported elsewhere [34][35][36]. After 14-18 weeks from the last boost, all animals were challenged intravenously (i.v.)…”
Section: Vaccination Protocol and Virus Challengementioning
confidence: 99%
“…The virus stock used was derived from a cynomolgus macaque inoculated with the original SHIV89.6P from rhesus monkeys [42]. Both the original viral stock grown in a rhesus macaque and the one grown in a cynomolgus monkey were highly pathogenic in M. fascicularis [34,35]. The pathogenicity in cynomolgus monkeys of both virus stocks was confirmed by the progression to AIDS and death (within 46 weeks from the inoculum) of four out of six and four out of seven cynomolgus monkeys infected, respectively, with the rhesus-or cynos-derived viral stock [35].…”
Section: Vaccination Protocol and Virus Challengementioning
confidence: 99%
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