Shock in Bantu Siderosis

Buchanan, W. M.

doi:10.1093/ajcp/55.4.401

Cited by 17 publications

(6 citation statements)

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“…Our findings demonstrate that mice homozygous for the deletion of the 1-major globin gene, resulting in ,Bthalassemia, are more susceptible to infection with L. monocytogenes than are phenotypically normal heterozygous mice. These results support clinical data indicating that patients with 1-thalassemia (6) and other anemias (3), as well as other iron-loading conditions (4,18,29), are at increased risk of infection.…”

Section: Discussionsupporting

confidence: 87%

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Resistance to infection in murine beta-thalassemia

et al. 1989

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Clinical evidence suggests that individuals with chronic iron overload may be at increased risk of bacterial infection. We studied this question by using a unique model in which mice homozygous for a deletion in the gene encoding for the a-major globin develop moderate anemia, splenomegaly, and tissue iron overload, a syndrome similar to 0-thalassemia in humans. Mice heterozygous for the gene deletion were phenotypically normal. Homozygous mice were significantly more susceptible to infection with Listeria monocytogenes than were heterozygous mice (P < 0.01). This increased susceptibility was associated with a greater number of organisms in the liver and spleen than was found in heterozygous mice (P < 0.05). However, histologic studies demonstrated similar inflammatory responses within these organs in homozygous and heterozygous mice. The increased susceptibility of homozygous mice to infection with L. monocytogenes was not seen when homozygotes were immunized with a low dose of L. monocytogenes. Although the results were not as striking as with L. monocytogenes, homozygous mice were also found to be more susceptible to infection with Salmonella

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Section: Discussionsupporting

confidence: 87%

“…Clinical evidence has long suggested that conditions associated with chronic iron excess lead to an increased risk of infection (3,4,6). More recently, reports have been published indicating that patients with chronic iron overload appear to be at higher risk for developing infection caused by the microorganism Listeria monocytogenes (18,29).…”

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confidence: 99%

Resistance to infection in murine beta-thalassemia

et al. 1989

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“…( 15 ) Similarly, in severe hemochromatosis and Bantu siderosis, acute episodes of abdominal pain and shock have been observed in individuals with extremely high serum iron measurements exceeding 2000 µmol/L. ( 16 )…”

Section: Catalytic Iron In the Biological Environmentmentioning

confidence: 99%

Role of iron in carcinogenesis: Cancer as a ferrotoxic disease

2009

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Iron is abundant universally. During the evolutionary processes, humans have selected iron as a carrier of oxygen inside the body. However, iron works as a double-edged sword, and its excess is a risk for cancer, presumably via generation of reactive oxygen species. Thus far, pathological conditions such as hemochromatosis, chronic viral hepatitis B and C, exposure to asbestos fibers, as well as endometriosis have been recognized as iron overload-associated risks for human cancer. Indeed, iron is carcinogenic in animal experiments. These reports unexpectedly revealed that there are target genes in iron-induced carcinogenesis and that iron-catalyzed oxidative DNA damage is not random in vivo. Several iron transporters and hepcidin, a peptide hormone regulating iron metabolism, were discovered in the past decade. Furthermore, a recent epidemiological study reported that iron reduction by phlebotomy decreased cancer risk in the apparently normal population. These results warrant reconsideration of the role of iron in carcinogenesis and suggest that fine control of body iron stores would be a wise strategy for cancer prevention. (Cancer Sci 2009; 100: 9-16)

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“…Three of these papers reported unusual infections (Pasteurella pseudotuberculosis and Yersinia enterocolitica) in patients with advanced liver disease some of whom also had haemochromatosis (42)(43)(44). In the two other reports, (45,46) irreversible shock in idiopathic haemachromatosis and Bantu siderosis was related by the reviewer to increased susceptibility to infection. Bacterial evidence for this was patchy.…”

Section: Chronic Iron Overloadmentioning

confidence: 99%

Iron and Infection: The Clinical Evidence

1989

Acta Paediatrica

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Oppenheimer, S. J. (Department of Paediatrics, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia). Iron and infection: The clinical evidence. Iron deficiency is prevalent in childhood in the developed and developing countries. Programs of presumptive therapy, mass supplementation and food fortification have been introduced in many countries. The unresolved debate over the interaction of iron and infection in the clinical setting prompts re‐evaluation of these practices. Situations of iron overload are associated with increased susceptibility to certain infections, although the exact mechanisms may vary with the main pathology. Iron treatment has been associated with acute exacerbations of infection, in particular malaria. In most instances parenteral iron was used. In the neonate parenteral iron is associated with serious E. coli sepsis. In one country, with endemic malaria, parenteral iron was associated with increased rates of malaria and increased morbidity due to respiratory disease in infants. In contrast in non‐malarious countries studies of oral iron supplementation have if anything shown a reduction in infectious morbidity. Methodological problems in the latter reports indicate the need for further controlled prospective studies with accurate morbidity recording if informed recommendations are to be made.

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Shock in Bantu Siderosis

Cited by 17 publications

References 0 publications

Resistance to infection in murine beta-thalassemia

Resistance to infection in murine beta-thalassemia

Role of iron in carcinogenesis: Cancer as a ferrotoxic disease

Iron and Infection: The Clinical Evidence

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