Shock, Sepsis, and Multiple Organ Failure: The Result of Whole-Body Inflammation

Goris, R.J.A.

doi:10.1007/978-3-642-76736-4_2

Cited by 7 publications

(1 citation statement)

References 122 publications

(117 reference statements)

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“…Various proinflammatory cytokines, such as tumor necrosis factor (TNF), interleukin 1 (IL-1), and IL-6, play important roles in the pathogenesis of septic shock and sepsis-related multiple organ dysfunction syndrome (MODS) (15). Advances in molecular biology have broadened our understanding of the immune responses during acute inflammation and permitted the development of novel approaches to the treatment of septic shock (24).…”

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Interleukin 10 reduces mortality from severe peritonitis in mice

Kato

Murata

Ishida

et al. 1995

Antimicrob Agents Chemother

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Interleukin 10 (IL-10) is known to suppress the induction of proinflammatory cytokines such as tumor necrosis factor (TNF) and IL-1 and is itself induced by monocytes and macrophages during sepsis. We studied the therapeutic efficacy of IL-10 by testing its effect on the survival rate in the murine cecal ligation-andpuncture (CLP) model. Administration of 1 g or more of recombinant murine IL-10 6 h after induction of sepsis decreased lethality in septic mice significantly and also suppressed the elevation of circulating TNF after sepsis. However, treatment with the same dose of IL-10 simultaneously or 6 h before induction of CLP had no effect on survival, and treatment with anti-TNF antibody after induction of CLP had no effect on the survival rate. These data suggest that cytokine modulation with IL-10 is a potential candidate for the treatment of sepsis and sepsis-related multiple organ failure.

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confidence: 99%