Shock Stress and DMBA-Induced Mammary Tumors

Newberry, Benjamin H.; Frankie, Gary; Beatty, Patricia A.; Maloney, Barbara D.; Gilchrist, Jackson

doi:10.1097/00006842-197207000-00003

Cited by 29 publications

(25 citation statements)

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“…As has been noted before (5,9,10), there are many possible explanations for these disparities, but it seems clear that replication of findings across host types, tumor types, and stressor types is basic to the development of sound models in this area. The primary purpose of the present experiments, therefore, was to attempt to confirm, with a different stressor, previous findings (5) of an inhibition of Huggins tumors [DMBA-induced rat mammary tumors (11)] by chronic electric shock. The stressor used was forced restraint.…”

Section: Introductionmentioning

confidence: 94%

“…Soviet workers (1,2) have reported generally facilitative effects of stressful conditions on a variety of experimental neoplasms, while other reports (3)(4)(5)(6)(7)(8) include inhibitory effects. As has been noted before (5,9,10), there are many possible explanations for these disparities, but it seems clear that replication of findings across host types, tumor types, and stressor types is basic to the development of sound models in this area. The primary purpose of the present experiments, therefore, was to attempt to confirm, with a different stressor, previous findings (5) of an inhibition of Huggins tumors [DMBA-induced rat mammary tumors (11)] by chronic electric shock.…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of Huggins Tumors by Forced Restraint

Newberry

Gildow

Wogan

et al. 1976

Psychosomatic Medicine

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Three experiments demonstrated that chronically administered restraint inhibits the development of DMBA-induced rat mammary tumors. The effect is exhibited in a lower proportion of positive responses, increased latency of tumor development, and lower number of tumors in positive animals when restrained animals are compared with controls. Organ weights failed to show a stress response to restraint. Molar activity data from Experiment III indicated that early in the experiment activity increased among the restrained animals on release from restraint. A fourth experiment, which employed a crystal accelerometer to assess activity, produced a similar activity pattern and also provided evidence of adrenal ascorbic acid depletion as a function of restraint.

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Section: Introductionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Inhibition of Huggins Tumors by Forced Restraint

Newberry

Gildow

Wogan

et al. 1976

Psychosomatic Medicine

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“…Experimental studies carried out on animals proved tumour-inhibitory (Newberry et al 1972(Newberry et al , 1976 as well as tumour-stimulatory effect (Tejwani et al 1991;Kavetsky et al 1966) of psychosocial factors on mammary tumourigenesis. Activation of the hypothalamicpituitary-adrenal system and sympathetic nervous system due to stress results in an increased production of catecholamines and glucocorticoids and consequent negative effects on functions of the immune system.…”

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confidence: 96%

Effect of a Short-Term and Long-Term Melatonin Administration on Mammary Carcinogenesis in Female Sprague-Dawley Rats Influenced by Repeated Psychoemotional Stress

Kassayová

Adámeková²,

Bojková

et al. 2007

Acta Vet. Brno

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The aim of this study was to evaluate the effect of melatonin (MEL) on N-methyl-N-nitrosourea (NMU)-induced mammary carcinogenesis in female Sprague-Dawley rats exposed to repeated psychoemotional stress -immobilization in boxes. NMU was applied intraperitoneally in two doses each of 50 mg/kg b.w. between 40 -50 postnatal days. Melatonin was administered in drinking water at a concentration of 4 μg/ml daily from 15:00 h to 8:00 h. The application was initiated 5 days prior to the fi rst NMU dose and lasted 15 days, i.e. during the promotion phase of tumour development, or long-term until the end of the experiment (week 20). Immobilization (2 h per day) began on the third day after the second carcinogen application and lasted for 7 consecutive days.Short-term MEL administration to immobilized animals increased incidence by 22%, decreased tumour frequency per animal by 26% and reduced tumour volume gain (by 21%) when compared to the immobilized group without MEL application. Decreased frequency per animal by 28% and more than a 40% decrease in tumour volume gain and cumulative volume were the most pronounced changes in the animals drinking MEL until the end of the experiment.Long-term MEL administration reduced the number and size of mammary tumours more markedly than its short-term administration. Melatonin decreased certain attributes of mammary carcinogenesis in female rats infl uenced by psychoemotional stress. Melatonin, mammary carcinogenesis, psychoemotional stress -restraint, ratBreast cancer is the most frequently diagnosed tumour in women world-wide. In most European countries the incidence is increasing; 350 000 new cases are recorded annually and annual mortality rate is 130 000 (Tyczynski et al. 2004). Chemically induced mammary carcinogenesis in rats is a widely used model to study preventive and therapeutic effects of various substances on tumour development. Melatonin (MEL) has been one of the most discussed substances since the 1970's. Melatonin is an endogenous pineal gland hormone and its oncostatic properties were proved mainly in hormone-sensitive mammary tumour in vivo and in vitro.Tumour-suppressive effects of MEL are exerted by different mechanisms of action. Indirect effect of MEL is produced through its inhibition of the activity of neuroendocrinereproductive axis with a consequent decrease in circulating levels of hormones that stimulate mammary tissue proliferation, mainly estrogens and prolactin (Tamarkin et al. 1981). MEL is capable of direct interaction with estrogen receptors resulting in their expression decrease and modulation of estrogen signal transfer

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“…The latter worker is one of several Russian investi gators who, in studies employing coal tar application to dogs with chronic neuroses and tumor-bearing mice as reviewed in two accounts [7,22], report ed that severe aversive stimulation tends to accelerate the growth of a variety of tumors, an effect which is dependent on a 'functional weakening of the cer ebral cortex'. N ewberry et al [15], in an attempt to verify that stress involv ing cortical function, as in a learning situation, facilitates tumor growth, sub jected rats injected with 9,10-dimethyl-1,2-benzanthracene to a conditioned avoidance experiment. However, the stressed rats developed fewer lesions than the respective controls.…”

Section: Introductionmentioning

confidence: 99%

“…However, the stressed rats developed fewer lesions than the respective controls. Although N ewberry et al [15] tried to repeat the Samundzhan experiments, both the species and type of tumor induction were different. Hoffman et al [6] inoculated rats with Walker tumor prior to forced exercise for 3 weeks and in all cases, the tumor weights were signifi cantly lower in the exercised animals.…”

Section: Introductionmentioning

confidence: 99%

Influence of Stress on Lesion Growth and on Survival of Animals Bearing Parenteral and Intracerebral Leukemia L1210 and Walker Tumors

Gershbein¹,

Benuck²,

Shurrager³

1974

Oncology

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Rats with Walker tumor injected intramuscularly in both hind legs and subjected to forced swimming for 15 min daily for 10 days displayed a trend toward decreased lesion size, especially in older intact animals as compared to unexercised intact or bilaterally adrenalectomized controls. Secondary tumor nodules occurred at the lower abdominal or inguinal areas and appeared to be more extensive in the older exercised rats. The survival rates offorced exercised rats bearing Walker tumor cortically did not differ significantly from the respective controls as was also the case with adult BDF₁ mice with intraperitoneal or cortical L1210 tumor and subjected daily to electroshock at 0.25 mA for 15 min.

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Shock Stress and DMBA-Induced Mammary Tumors

Cited by 29 publications

References 0 publications

Inhibition of Huggins Tumors by Forced Restraint

Inhibition of Huggins Tumors by Forced Restraint

Effect of a Short-Term and Long-Term Melatonin Administration on Mammary Carcinogenesis in Female Sprague-Dawley Rats Influenced by Repeated Psychoemotional Stress

Influence of Stress on Lesion Growth and on Survival of Animals Bearing Parenteral and Intracerebral Leukemia L1210 and Walker Tumors

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