Shockwave Lithotripsy and Protective Role of Inosine: Early and Late Evaluation in an Experimental Model

Abstract

Inosine is helpful and protective in the prevention of early microscopic damage to renal parenchyma due to SWL.

Extracorporeal Shock Wave Lithotripsy in an Elderly Population: How to Prevent Complications and Make the Treatment Safe and Effective

“…A total of 55 subjects had radiolucent renal stones; the location was both caliceal (34) and pielic (21). Forty-three of them presented with concomitant hyperuricaemia, thus receiving a therapy with allopurinol 300 mg per day.…”

“…SWL safety represents an interesting topic of the recent international literature. 21 the application of simple suggestions can limit or avoid risks connected to SWL, and make the procedure safe and tolerated even by old patients.…”

Reduction of shock wave lithotripsy-induced renal tubular injury by tadalafil

“…The effects of SWL on renal morphology and renal function have been studied previously (8)(9)(10). According to these studies, the energy released by shock waves produces cavitations or bubbles that may cause direct injury to the renal vasculature.…”

RE: Renal protective effect of N-acetylcysteine with stepwise ramping voltage against extracorporeal shock wave lithotripsy-induced renal injury: a prospective randomized trial from Desoky et al

“…The possible nephron-protective role of NAC has been successfully used by Desoky et al [1] to prevent tissue alteration and injury following ESWL: in this setting, NAC administration before and after the treatment resulted in unimpaired levels of urinary proteins and enzymes representative of glomerular and tubular damage (albumin, NAG and NGAL), especially if accompanied by a stepwise ramping strategy of ESWL. Interestingly, more than a decade ago, our group addressed the issue of kidney protection with the use of inosine injection before ESWL [3]; through an experimental study, we found an unimpaired NAG and LDH urinary concentrations after ESWL in rats previously treated with inosine. Unfortunately, at that time, the limited availability of inosine avoided further researches on application in the clinical practice.…”