Short- and long term antibacterial effects of a single rinse with different mouthwashes: A randomized clinical trial

Herczegh, Anna; Csák, Boglárka; Dinya, Elek; Moldován, Anna; Ghidán, Ágoston; Palcsó, Barnabás; Lohinai, Zsolt

doi:10.1016/j.heliyon.2023.e15350

Cited by 3 publications

(5 citation statements)

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“…S. mutans and E. coli biofilms were the most susceptible to ASC1 and ASC2. Accordingly, Herczegh et al showed that 0.0015% and 0.003% solutions of ClO 2 solutions are promising preventive and therapeutic adjuvants in dental practice [43]. SC was more effective against the biofilm of S. mutans than ASC1 and ASC2 ( Table 2, Figure 2 ), which stays in line with reports showing that biofilm formation and matrix gene transcription can be stimulated by sublethal (4 μg/ml; 150ppm) doses of ClO 2 [44,45].…”

Section: Discussionmentioning

confidence: 99%

No Miracle, Just a Mineral: The Not-So-Magical Antimicrobial World of Chlorine Dioxide

Dudek-Wicher,

Brożyna,

Paleczny

et al. 2024

Preprint

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This study evaluates thein vitroantimicrobial efficacy and cytotoxicity of acidified sodium chlorite (ASC), a source of chlorine dioxide. Despite its controversial promotion in alternative medicine as a cure-all solution, known as “Miracle Mineral Solution” (MMS), the data on its factual medicinal activity is very limited. Therefore, we aimed to elucidate the activity of ASC against biofilms ofStaphylococcus aureus, Pseudomonas aeruginosa, Enterococcus faecalis, Streptococcus mutans, Pseudomonas aeruginosa, Escherichia coli, andLactobacillus sp. The study also investigated the in vitrocytotoxic effects of ASC towards eukaryotic fibroblasts and inin vivomodel ofGalleria mellonellalarvae. Our findings demonstrate that these concentrations of ASC which can effectively eradicate biofilms, also pose potential health risks due to theirin vitroandin vivocytotoxicity. It implies that ASC applied in human can lead to damage to the mucous membrane of the gastrointestinal tract. This research contributes to the ongoing debate on the safety and efficacy of chlorine dioxide in clinical applications, highlighting the need for precise dosing to avoid mucosal damage in therapeutic contexts.

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Section: Discussionmentioning

confidence: 99%

No Miracle, Just a Mineral: The Not-So-Magical Antimicrobial World of Chlorine Dioxide

Dudek-Wicher,

Brożyna,

Paleczny

et al. 2024

Preprint

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“…We will perform randomization if eligibility criteria are fulfilled. After baseline data have been recorded, interventions will be performed.The test group will use a 25 ml 10-fold dilution of hyperpure 0.03% ClO 2 (Solumium Coral®, final concentration: 0.003%) [ 30 ], and the control group will use chlorhexidine-containing mouthwashes (Curasept ADS 220, 0.2%). Rinsing will last 2 × 15 s in both groups as recommended by the manufacturer (2 × 12.5 ml) [ 31 ].…”

Section: Methodsmentioning

confidence: 99%

Hyperpure chlorine dioxide versus chlorhexidine in intra-oral halitosis (ODOR trial) – protocol of a double-blinded, double-arm, parallel non-inferiority pilot randomized controlled trial

Szalai,

Teutsch,

Babay

et al. 2024

BDJ Open

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Introduction Intra-oral halitosis (IOH) is the most common type of bad breath; its consequences impair quality of life. However, evidence-based treatment protocols and guidelines are lacking. Our aim is to investigate the effectiveness of chlorine dioxide as an applicable complementary treatment modality in IOH after tongue cleaning. Methods and analysis The ODOR trial will be a single-center, double-blinded, parallel-group, double-armed pilot randomized controlled trial with a non-inferiority design. The efficacy of hyperpure chlorine dioxide will be compared to chlorhexidine mouthwash. We plan to investigate the short-term effects of the intervention over a 3-h period. The primary endpoint will be changes in organoleptic test scores. At the end of the pilot investigation of the first 30 patients each, sample size calculation will be performed. If feasible, the investigators will continue the study by enrolling more patients. Trial registration The trial has been registered at ClinicalTrials.gov (NCT06219226).

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“…Chlorine dioxide antiseptic mouthwash and petroleum jelly were used to maintain lip moisture. Chlorine dioxide has antibacterial, antiviral, antifungal, pain relief, and tissue healing effects [21][22][23]. Its diverse effectiveness makes chlorine dioxide often used in dental practice, including to relieve pain after wisdom tooth extraction, improve the healing process after oral surgical procedures, effective endodontic irrigation materials, treatment for periodontal disease, and halitosis [22,24].…”

Section: Fig 3: Clinical Features Of the Patient's Lips And Oral Cavi...mentioning

confidence: 99%

“…Its diverse effectiveness makes chlorine dioxide often used in dental practice, including to relieve pain after wisdom tooth extraction, improve the healing process after oral surgical procedures, effective endodontic irrigation materials, treatment for periodontal disease, and halitosis [22,24]. Chlorine dioxide dissolves well in water and penetrates biofilms well [22,23]. Chlorine dioxide is a selective oxidizing agent.…”

Section: Fig 3: Clinical Features Of the Patient's Lips And Oral Cavi...mentioning

confidence: 99%

“…The antibacterial activity is derived from its reaction with those three amino acids, their acidic residues in proteins, and peptides preventing bacteria resistance. The compound also oxidizes precursors of volatile sulfur compounds (VSC) so it functions as an anti-halitosis [23][24][25]. Cell viability tests show that chlorine dioxide is only toxic at very high concentrations, to human gingival fibroblasts [21,22].…”

Section: Fig 3: Clinical Features Of the Patient's Lips And Oral Cavi...mentioning

confidence: 99%

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The Use of Tranexamic Acid Mouthwash in the Gingival Bleeding Management in Aplastic Anemia Patient

BAKTI,

FITRIASARI,

WAHYUNI

2023

Int J App Pharm

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Objective: The aim of this study was to describe the role of tranexamic acid mouthwash in the management of gingival bleeding in aplastic anemia patients. Methods: Complete subjective, objective, and supporting examinations were carried out to confirm the diagnosis. Treatments were given in collaboration between the departments of internal and oral medicine. Anamnesis and history taking were done, and it was revealed that a 21-year-old male patient came with the chief complaint of active anterior mandible gum bleeding, starting two weeks ago and accompanied by fever. Extra-oral examination revealed a hematoma on the lip. Intra-oral examination found spontaneous bleeding from the anterior mandible gingiva and hematomas on the labial mucosa and lateral of the tongue. Laboratory examination results showed hemoglobin, hematocrit, erythrocytes, leukocytes, and platelets below the normal range, and the bone marrow morphology examination confirmed the diagnosis of aplastic anemia. Results: Treatment included a blood transfusion of 39 flasks for 14 d for the systemic condition. Tranexamic acid and chlorine dioxide mouthwash were given for intra-oral problems, and petroleum jelly to treat lip lesions. Gingival bleeding and hematomas resolved within 8 d. Conclusion: Tranexamic acid mouthwash, along with manual scaling of calculus, which is a predisposing factor for gingival bleeding, as well as blood transfusion, have an important role in the successful comprehensive management of gingival bleeding due to pancytopenia in patients with aplastic anemia.

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Short- and long term antibacterial effects of a single rinse with different mouthwashes: A randomized clinical trial

Cited by 3 publications

References 25 publications

No Miracle, Just a Mineral: The Not-So-Magical Antimicrobial World of Chlorine Dioxide

No Miracle, Just a Mineral: The Not-So-Magical Antimicrobial World of Chlorine Dioxide

Hyperpure chlorine dioxide versus chlorhexidine in intra-oral halitosis (ODOR trial) – protocol of a double-blinded, double-arm, parallel non-inferiority pilot randomized controlled trial

The Use of Tranexamic Acid Mouthwash in the Gingival Bleeding Management in Aplastic Anemia Patient

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