Short and long term effect of treatment non-pharmacological and lifestyle in patients with metabolic syndrome

Abstract

Background: Metabolic syndrome (MS) is a complex disorder represented by a set of cardiovascular risk factors usually related to central fat deposition, insulin resistance, hypertension and dyslipidemia. It is associated with accelerated atherosclerosis in response to chronic inflammation and vascular endothelial dysfunction, increasing overall mortality. The objective to evaluate the short and long term effect of the comprehensive cardiac rehabilitation program and intensive lifestyle intervention in metabolic syndrome patients. Methods: This is longitudinal interventional study. All patients underwent a 20-session cardiac rehabilitation program with aerobic and resisted exercises as well as an educational program for lifestyle changes and follow up 1 year. Results: Forty seven patients participated in the present study, but only 28 concluded the follow up. 77.7% were females and the majority was older than 60 years (63.1%). After cardiac rehabilitation, the percentage of overweight (0.04) patients who controlled the SBP (0.04) increased, and obesity levels I and II were reduced, as well as a significant reduction in total cholesterol and triglycerides (0.01 and 0.05), all of these variables remained similar after 1 year of follow-up. After cardiac rehabilitation all participants were practicing the five factors of healthy lifestyle, and reduced to 73% after follow up. Conclusion: A comprehensive cardiac rehabilitation program and lifestyle change is an effective approach in the treatment of patients with MS mainly, it has positive short and long term effects on weight control, reducing total cholesterol and triglycerides.

Preconceptional evaluation of women with recurrent pregnancy loss: the additional value of assessing vascular and metabolic status

“…The relevance of our findings to clinical practice can be highlighted by observations from the several studies showing that vascular and metabolic abnormalities in pregnant and non-pregnant women can be treated with help of lifestyle interventions, which are relatively easy to implement in practice [ 28 , 29 ]. Improved lifestyle will result in more favorable parameters and therefore increase the chance for a healthy pregnancy [ 29 ].…”

“…The relevance of our findings to clinical practice can be highlighted by observations from the several studies showing that vascular and metabolic abnormalities in pregnant and non-pregnant women can be treated with help of lifestyle interventions, which are relatively easy to implement in practice [ 28 , 29 ]. Improved lifestyle will result in more favorable parameters and therefore increase the chance for a healthy pregnancy [ 29 ]. The risk of the MetS and CVD later in life could decrease simultaneously and therefore might have the dual benefit of improving women’s general health and fulfilling the aspiration of a healthy ongoing pregnancy.…”

Associations Of Delta Fatty Acid Desaturase Gene Polymorphisms With Lipid Metabolism Disorders

“…Metabolic syndrome (MS) is defined as a group of metabolic disorders that are the risk factors for developing cardiovascular pathologies and type 2 diabetes [1,10,77,78]. The components of MS are arterial hypertension, abdominal obesity, disorders of carbohydrate metabolism, and dyslipidemia [10,77]. Lipid changes can be both a cause and a consequence of impaired glucose metabolism and insulin resistance.…”

“…The lack of essential FAs impairs the resolution of inflammation and results in the development of a slow chronic low-grade inflammation [7,8]. This type of inflammation underlies many non-communicable chronic diseases and conditions accompanied by lipid metabolism dysfunction, in particular obesity, cardiovascular diseases (CVDs), type 2 diabetes mellitus (DM2), metabolic syndrome (MS), non-alcoholic fatty liver disease (NAFLD) [1,[8][9][10][11]. Obesity, overweight, MS, CVDs, and NAFLD are common in both adults and children [12,13].…”

Influence of Therapy Compliance Using Medication Possession Ratio Method for Patients with Metabolic Syndrome

“…These changes impact on reducing all metabolic risk factors. 10 The biggest challenge in treating chronic patients (hypertension, dyslipidemia, and diabetes) is maintaining therapy compliance and a healthy lifestyle. Compliance with treatment therapy is someone's behaviour to take medication, follow a diet, and make lifestyle changes based on healthcare recommendations.…”