Short- and long-term efficacy and safety of triple vs. dual antithrombotic therapy in patients with drug-eluting stent implantation and an indication for oral anticoagulation: a meta-analysis

Abstract

For patients on OAC after coronary stenting, triple therapy (OAC, aspirin, clopidogrel) should be considered in the short term, followed by more long-term therapy with OAC plus clopidogrel. More randomized studies are needed to confirm these findings.

The safety and efficacy of oral anticoagulants with dual versus single antiplatelet therapy in patients after percutaneous coronary intervention

“…However, our study was different from several previous meta-analyses relative to the comparison of TT with OAC and a single antiplatelet. [ 6 , 12 , 13 , 31 ] Compared with other meta-analyses, our study had apparent advantages. First, the present meta-analysis included 12 studies with a total of 30,823 patients, representing far more subjects than these previous meta-analyses.…”

“…Currently, some specialists recommend that dual therapy (DT; OAC with single antiplatelet) can replace TT for similar efficacy outcomes and without the additional risk of bleeding. Therefore, some studies [ 8 – 11 ] and several meta-analyses [ 6 , 12 , 13 ] have been performed to evaluate the safety and efficacy of TT compared with DT, but the results are inconsistent. A previous meta-analysis showed data selection and methodological biases and 2 new studies have since been published.…”