Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review

Kabak, Vesile Yıldız; Düger, Tülin; Mohammed, Jibril; Breda, Eric van

doi:10.1007/s00520-018-4483-8

Cited by 29 publications

(14 citation statements)

References 72 publications

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“…As PedHM survivors move from the beginning of cancer treatment into their full potential as young adults, many of them would be well advised to embrace many of the 2030 Sustainable Development Goals, as identified in the 2016 Bangkok declaration on physical activity for global health and sustainable development 3 . A global glance at childhood cancer survivors invariably shows poor levels of fitness that are continuous and life-long, even after all cancer treatment, though there are a limited number of high-quality studies available in this area of research 4 .…”

Section: Introductionmentioning

confidence: 99%

Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies

Lanfranconi

Zardo

Moriggi

et al. 2020

Sci Rep

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children and adolescents with haematological malignancies (pedHM) are characterized by a severe loss of exercise ability during cancer treatment, lasting throughout their lives once healed and impacting their social inclusion prospects. The investigation of the effect of a precision-based exercise program on the connections between systems of the body in pedHM patients is the new frontier in clinical exercise physiology. This study is aimed at evaluating the effects of 11 weeks (3 times weekly) of combined training (cardiorespiratory, resistance, balance and flexibility) on the exercise intolerance in PedHM patients. Two-hundred twenty-six PedHM patients were recruited (47% F). High or medium frequency participation (HAd and MAd) was considered when a participant joined; > 65% or between 30% and < 64% of training sessions, respectively. The "up and down stairs'' test (TUDS), "6 min walking" test (6MWT), the "5 Repetition Maximum strength" leg extension and arm lateral raise test (5RM-LE and 5RM-ALR), flexibility (stand and reach), and balance (stabilometry), were performed and evaluated before and after training. The TUDS, the 5RM-LE and 5RM-ALR, and the flexibility exercises showed an increase in HAd and MAd groups (P < 0.05), while the 6MWT and balance tests showed improvement only in HAd group (P < 0.0001). these results support the ever-growing theory that, in the case of the treatment of PedHM, 'exercise is medicine' and it has the potential to increase the patient's chances of social inclusion.

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Section: Introductionmentioning

confidence: 99%

Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies

Lanfranconi

Zardo

Moriggi

et al. 2020

Sci Rep

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“…If the I 2 value was >0%, we calculated 95% prediction intervals in addition to the 95% CIs . We performed sensitivity analyses according to methodological study quality if at least five moderate to high‐quality studies (NOS score <6 as was rated as low quality and ≥6 as moderate to high quality) were available. Subgroup analyses according to clinical presentation were added when at least three studies reported subgroup‐specific outcome data.…”

Section: Methodsmentioning

confidence: 99%

Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta‐analysis of controlled studies

Appenzeller-Herzog

Mathes

Heeres

et al. 2019

Liver International

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Background & aims Wilson disease (WD) is a rare disorder of copper metabolism. The objective of this systematic review was to determine the comparative effectiveness and safety of common treatments of WD. Methods We included WD patients of any age or stage and the study drugs D‐penicillamine, zinc salts, trientine and tetrathiomolybdate. The control could be placebo, no treatment or any other treatment. We included prospective, retrospective, randomized and non‐randomized studies. We searched Medline and Embase via Ovid, the Cochrane Central Register of Controlled Trials, and screened reference lists of included articles. Where possible, we applied random‐effects meta‐analyses. Results The 23 included studies reported on 2055 patients and mostly compared D‐penicillamine to no treatment, zinc, trientine or succimer. One study compared tetrathiomolybdate and trientine. Post‐decoppering maintenance therapy was addressed in one study only. Eleven of 23 studies were of low quality. When compared to no treatment, D‐penicillamine was associated with a lower mortality (odds ratio 0.013; 95% CI 0.0010 to 0.17). When compared to zinc, there was no association with mortality (odds ratio 0.73; 95% CI 0.16 to 3.40) and prevention or amelioration of clinical symptoms (odds ratio 0.84; 95% CI 0.48 to 1.48). Conversely, D‐penicillamine may have a greater impact on side effects and treatment discontinuations than zinc. Conclusions There are some indications that zinc is safer than D‐penicillamine therapy while being similarly effective in preventing or reducing hepatic or neurological WD symptoms. Study quality was low warranting cautious interpretation of our findings.

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“…36 The first aim of this study was to investigate whether motor ability, physical self-concept and QoL are lower in PCS compared to TD children. Against the background of poorer aerobic fitness, strength and coordination [21][22][23] in PCS, we expected to detect poorer motor ability in PCS compared to TD children. Considering the meta-analytical results showing a lower self-concept in children and adolescents with chronic health conditions, 37 and the results of a recent systematic review indicating a reduced QoL in PCS, 4 we expected lower physical self-concept and QoL ratings in PCS compared to TD children.…”

Section: Introductionmentioning

confidence: 96%

“…[18][19][20] For example, there is evidence for poorer aerobic fitness, strength, balance, and coordination in PCS. [21][22][23] Such deficits are not only reflected in objective assessments, but also in subjective reports of performance limitations. 24,25 The physical self-concept, defined as the subjective selfevaluation of one's physical attributes in areas of physical ability and appearance, is a hierarchically organized and multidimensional construct.…”

Section: Introductionmentioning

confidence: 99%

Motor ability, physical self‐concept and health‐related quality of life in pediatric cancer survivors

et al. 2021

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Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review

Cited by 29 publications

References 72 publications

Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies

Precision-based exercise as a new therapeutic option for children and adolescents with haematological malignancies

Comparative effectiveness of common therapies for Wilson disease: A systematic review and meta‐analysis of controlled studies

Motor ability, physical self‐concept and health‐related quality of life in pediatric cancer survivors

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