Short- and Long-Term Outcomes of Every Graft Recovered During a Multi-Organ Procurement Procedure Including the Intestine

Farinelli, Pablo; Padín, Juan Manuel; Troncoso, Juan C.; Bertolotti, Alejandro; Lenz, M.; Sanchez, Nicole; Fortunato, Rita Marcela; Caravello, Esteban; Imperiali, Nora; Dip, Marcelo; Clariá, Rodrigo Sanchez; Arriola, M.; Arteaga, Javier de; Soler, Gwendoline; Bisigniano, Liliana; Gil, O.; McCormack, Lucas; Botta, E; Inventarza, O; Gaite, L.J.; Hyon, Sung Ho; Raffaele, Pablo; Illanes, G.; Santibañez, Eduardo de; Favaloro, Roberto; Gondolesi, Gabriel

doi:10.1016/j.transproceed.2014.06.040

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…On the other, several heart and lung procurement/transplant teams fear inferior outcomes of their graft, if an intestinal graft is concomitantly procured and if special donor preprocurement therapies were initiated. However, the study by Farinelli et al showed that these intestinal donor preprocurement therapies might even be beneficial for other transplanted organs, without impacting allocation, quality or long-term outcome [ 27 ]. ITx may also compete with other organ transplant activities for theater and personnel.…”

Section: Discussionmentioning

confidence: 99%

Intestinal Donation and Utilization: Single-Center Analysis Within Eurotransplant

Clarysse,

Vanuytsel,

Canovai

et al. 2023

Transpl Int

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Intestinal donor criteria are classically kept strict, thereby limiting donor supply. Indications for intestinal transplantation (ITx) are rare, but improved outcome and new emerging indications lead to increased demand and relaxing donor criteria should be considered. We sought to compare the donor criteria of intestines transplanted at our center with predefined (per protocol) criteria, and to determine how relaxing donor criteria could impact the potential donor pool. Donor criteria used in 22 consecutive ITx at our center between 2000 and 2020 were compared with predefined criteria. Next, multiorgan donors effectively offered by our Donor Network to Eurotransplant between 2014 and 2020 were retrospectively screened, according to predefined and effectively used intestinal donation criteria. Finally, utilization rate of offered intestines was calculated. In our ITx series, the effectively used donor criteria were less strict than those initially predefined. With these relaxed criteria, a favorable 5-year graft/patient survival of 75% and 95%, respectively was reached. Applying these relaxed criteria would lead to a 127% increase in intestinal offers. Paradoxically, 70% of offered intestines were not used. In conclusion, a significant increase in intestinal donation could be obtained by relaxing donor criteria, while still achieving excellent outcome. Offered intestines are underutilized.

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Section: Discussionmentioning

confidence: 99%

Intestinal Donation and Utilization: Single-Center Analysis Within Eurotransplant

Clarysse,

Vanuytsel,

Canovai

et al. 2023

Transpl Int

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“…Intestinal grafts maybe a part of multi-organ procurement, and such donors are often treated with thymoglobulin and a warm dissection. This had not adversely affected the quality or the long term results [12]. Though greater team efforts and longer organization times maybe needed, long term graft and patient survival rates are better [12] Preservation of arterial vessels of celiac and/or superior mesenteric arteries, and venous outflow of superior mesenteric vein or hepatic veins is beneficial.…”

Section: Cadaveric Graftsmentioning

confidence: 99%

“…This had not adversely affected the quality or the long term results [12]. Though greater team efforts and longer organization times maybe needed, long term graft and patient survival rates are better [12] Preservation of arterial vessels of celiac and/or superior mesenteric arteries, and venous outflow of superior mesenteric vein or hepatic veins is beneficial. The celiac and superior mesenteric arteries are retained in the larger liver grafts, whereas the superior mesenteric artery and vein are retained in the isolated intestinal grafts (Fig.…”

Section: Cadaveric Graftsmentioning

confidence: 99%

Intestinal transplantation: The anesthesia perspective

Dalal

2016

Transplantation Reviews

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“…Rigorous assessment of a potential donor is mandatory prior to proceeding organ procurement. For DBD and DCD donors, procurement of multi-organs is always the priority to ultimately benefit multiple recipients without jeopardizing the graft function [1,2].…”

Section: Introductionmentioning

confidence: 99%

Procurement of Abdominal Organs in Multi-Organ Donation in Deceased Donor

He¹,

Han²,

Fink³

2018

Organ Donation and Transplantation - Current Status and Future Challenges

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Organ procurement is an essential step for organ transplantation, from which a quality organ is received for subsequent transplantation. As the demand for organ transplantation continues to grow, multi-organ donation including the heart, lung, live, pancreas, kidneys, and small intestine from one potential donor is always a priority to meet the demand. The donor is generally rigorously assessed for suitability of organ donation prior to proceeding to organ procurement. The quality of the organ from multi-organ procurement is usually satisfactory without jeopardizing its transplantation. In this chapter, the surgical technique for procurement of the organs from the abdomen is described. Some alternative techniques have also been discussed. Some pictures are inserted to facilitate understanding of the surgical procedure.

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Short- and Long-Term Outcomes of Every Graft Recovered During a Multi-Organ Procurement Procedure Including the Intestine

Cited by 8 publications

References 21 publications

Intestinal Donation and Utilization: Single-Center Analysis Within Eurotransplant

Intestinal Donation and Utilization: Single-Center Analysis Within Eurotransplant

Intestinal transplantation: The anesthesia perspective

Procurement of Abdominal Organs in Multi-Organ Donation in Deceased Donor

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