Short- and Long-Term Self-Reported Symptoms in Adolescents Aged 12–19 Years after Vaccination against SARS-CoV-2 Compared to Adolescents Not Vaccinated—A Danish Retrospective Cohort Study

Berg, Selina Kikkenborg; Kildemoes, Helle Wallach; Rasmussen, Line Ryberg; Nygaard, Ulrikka; Bundgaard, Henning; Petersen, Maria Nivi Schmidt; Hammer, Cecilie Bech; Ersbøll, Annette Kjær; Thygesen, Lau Caspar; Nielsen, Susanne Dam; Christensen, Anne Vinggaard

doi:10.3390/vaccines10111863

Cited by 4 publications

(4 citation statements)

References 26 publications

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“…A previous study from this cohort investigating self-reported symptoms in the first 14 days following BNT162b2 vaccination found that vaccinated adolescents reported more headaches, tiredness, and gastrointestinal symptoms compared to unvaccinated adolescents [ 23 ]. Similarly, in another American study using Vaccine Adverse Event Reporting System (VAERS) data, some of the most common self-reported symptoms were fatigue, headaches, chills, and pyrexia among vaccinated adolescents [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study

et al. 2023

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In this register-based real-life cohort study, changes in symptom-specific hospital contacts among 12–18-year-olds following two doses of the BNT162b2 COVID-19 vaccine compared to unvaccinated peers were investigated. Using national register data, vaccinated and unvaccinated adolescents were sex and age-matched each week during the inclusion period from May to September 2021. Symptom-specific hospital contacts covering ICD-10 R diagnoses were assessed before first the vaccine dose and after the second vaccine dose. Taking previous rates of symptom-specific hospital contacts into account, differences between vaccinated and unvaccinated adolescents were found. For some hospital contacts, higher rates were seen among the vaccinated, and for others, higher rates were seen among the unvaccinated. Unspecific cognition symptoms may be important to monitor in vaccinated girls, and likewise for throat and chest pain in vaccinated boys within the first months post-vaccination. In perspective, symptom-specific hospital contacts after vaccination against COVID-19 must be assessed by taking the risk of infection and symptoms following COVID-19 infection into account.

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Section: Discussionmentioning

confidence: 99%

Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study

et al. 2023

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“…The variables included in the present study were vaccine data, type and number of doses, use of medication prior to vaccination to prevent symptoms (yes, no), and type of side effect (the participant chose from a list made with short-term side effects reported in the literature). The side effects were self-reported, similar to many observational studies [8,[20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. Dose 1 and 2 side effects were questioned in separate sections.…”

Section: Study Variablesmentioning

confidence: 99%

“…Plenty of studies have reported the safety and efficacy of COVID-19 vaccines [ 7 , 8 , 9 , 10 , 11 , 12 , 13 ], but these are all clinical trials conducted on healthy participants with no participation of pregnant or breastfeeding women. However, observational studies had shown vaccines were safe in these populations, several of which were based on self-reported symptoms post-vaccination [ 8 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ]. We have previously reported the side effects caused by seven COVID-19 vaccines in the Mexican population [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Side Effects of COVID-19 Vaccines in Pregnant and Lactating Mexican Women and Breastfed Infants: A Survey-Based Study

et al. 2023

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COVID-19 vaccines’ safety has been extensively studied; however, further analysis is required in pregnant women, nursing mothers, and breastfed infants. Our aim was to compare the extension and severity of self-reported COVID-19 vaccine side effects in pregnant and breastfeeding women, and breastfed infants. In this cross-sectional study, COVID-19-vaccinated subjects were enrolled using an online survey in Mexico. Women were classified by pregnancy and breastfeeding status at the time of vaccination (n = 3167). After the first or only dose, there was a trend toward fewer systemic effects in pregnant women (p = 0.06). BNT162b2 (Pfizer–BioNTech) had a higher frequency of local symptoms in pregnancy. Lactating women experienced fewer local symptoms after the first or single dose (p = 0.04) and the opposite occurred after the second dose (p = 0.001). ChAdOx1 (AstraZeneca) increased the chances of developing both local and systemic symptoms after the first dose but decreased them after the second dose. The severity was similar across groups, although the result of lack of association in pregnancy requires studies with a larger sample size. Irritability was the most reported symptom in breastfed infants. This study contributes to the knowledge about the side effects in pregnant and lactating women, and breastfed babies.

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“…[17][18][19] In rare cases, more serious adverse effects, such as myopericarditis and thrombotic events, may occur in adolescents and young adults but usually with a favorable prognosis. 20,21 While studies show that the overall adverse effects among the global population are mild and self-limited, 22 there is limited research specifically focused on type, intensity, onset, difference between each dose, and natural history of the adverse effects among university students.…”

Section: Introductionmentioning

confidence: 99%

Adverse effects of COVID-19 vaccines in university students

Jongmekwamsuk,

Hanvivattanakul,

Vanichanan

et al. 2024

F1000Res

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Background Existing data on adverse effects of coronavirus disease 2019 (COVID-19) vaccines among university students are limited. This study aimed to investigate the characteristics of adverse effects that may arise from administering COVID-19 vaccines to university students in Thailand. Methods An online survey study was conducted among students from 12 Health Sciences faculties, and from 16 non-Health Sciences faculties of two universities from October 2021 to January 2022 to assess types and adverse effects of COVID-19 vaccines received by the students. Results There were 1,439 participating students; 522 (36%) were from Health Sciences faculties, and 917 (64%) were from 16 non-Health Sciences faculties. The types of the first-dose vaccine received were inactivated (49%), viral vector (46%), and mRNA (5%), while the types of the second-dose vaccine received were viral vector (53%), inactivated (40%) and mRNA (7%). The first-dose vaccines’ most common adverse effects of inactivated, viral vector, and mRNA vaccines were muscle pain (47%, 82%, and 58%, respectively). The second-dose vaccines’ most common adverse effects were cough (47%) for inactivated vaccines and muscle pain (49% for viral vector vaccines and 56% for mRNA vaccines). Viral vector vaccines were more likely to cause fever, muscle pain, diarrhoea, headache, and rashes than the others. The mRNA vaccines caused injection site pain more than inactivated vaccines. The majority of adverse effects occurred 24-48 hours after vaccination (68%), were more severe with the first dose compared with the second dose, and resolved spontaneously without any treatment at a hospital. Conclusions The adverse effects experienced by the students were various according to the types and number of doses of COVID-19 vaccines. The adverse effects were mostly non-severe and occurred less for the second dose compared with the first dose.

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Short- and Long-Term Self-Reported Symptoms in Adolescents Aged 12–19 Years after Vaccination against SARS-CoV-2 Compared to Adolescents Not Vaccinated—A Danish Retrospective Cohort Study

Cited by 4 publications

References 26 publications

Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study

Symptom-Specific Hospital Contacts in 12–18-Year-Olds Vaccinated against COVID-19: A Danish Register-Based Cohort Study

Side Effects of COVID-19 Vaccines in Pregnant and Lactating Mexican Women and Breastfed Infants: A Survey-Based Study

Adverse effects of COVID-19 vaccines in university students

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