Short- and Long-Term Survival of Esophageal Cancer Patients Treated at the Cancer Institute of Iran

Abstract

Introduction: Little data is available on the prognosis of esophageal cancer (EC) in Iran. We studied the short- and long-term survival of EC patients treated at the Cancer Institute of Iran. Methods: 619 patients were followed who had been operated in the years 1997-2006. The 1-month to 5-year survival rates of EC and hazard ratios (HR) for different prognostic factors were estimated. Results: Median survival was 11.5 months and 5-year survival was 10%. Patients at the advanced stage had a 2.1-fold higher risk of mortality compared to the early stage (95% CI 1.2-3.4). One-month mortality decreased from 12.2 in 1997-1999 to 9.1% in 2003-2006. In the first month, patients who were diagnosed in 2003-2006 had a significantly (60%) lower HR compared to 1997-1999 (HR = 0.4, 95% CI 0.1-0.9). In addition, patients with cardiopulmonary complications had an 11.7-fold higher HR compared to patients without complications (95% CI 4.7-29.3). Conclusions: The 5-year survival rate for operated EC patients was considerably low in Iran. Cardiopulmonary complications were the strong prognostic factors for first-month mortality. We suggest improving the pre- and postoperative care of EC to control these complications. Regular monitoring of patient survival is recommended to evaluate the effect of this intervention.

Predictors of survival in oesophageal cancer patients in a high-risk area in Northern Iran: the role of health services utilisation

“…Similarly, a median survival time of 8.5 months was reported in a nation-wide study from Iran (Harirchi et al, 2014). Mir et al (2013) reported a median survival of 11.5 months and a 5-year survival rate of 10% for EC patients from Tehran, Iran. In a recent systematic review on 18 studies from Iran, the 1-and 5-year survival rates of EC were estimated at 47% and 12% respectively (Yarhusseini et al, 2014).…”

“…Samadi et al (2007) reported a median survival of 9 months for EC patients from North-West of Iran. Mir et al (2013) reported a median survival of 11.5 months and a 5-year survival rate of 10% for EC patients from Tehran, Iran. Mir et al (2013) reported a median survival of 11.5 months and a 5-year survival rate of 10% for EC patients from Tehran, Iran.…”

Contact with ruminants is associated with esophageal squamous cell carcinoma risk

“…Another study from Cancer Institute of Iran 26 showed very similar characteristics to the recruited patients 27 ;i.e. similar stage (10% in early stage), gender proportion (45–50% Female) and age.…”

“…Another study from Cancer Institute of Iran 26 showed very similar characteristics to the recruited patients 27 ; that is, similar stage (10% in early stage), gender proportion (45-50% Female) and age. Although there is no direct data available to compare recruited subjects to those who did not visit clinic, due to homogenous population and similar socioeconomic conditions, in addition to indirect evidences from cancer registrybased study, 26 it is improbable that nonrecruited cases would markedly different form recruited subjects. Additionally, as controls were matched geographically, they would follow same referral pattern in case of developing symptoms.…”

Conditional survival after neoadjuvant chemoradiotherapy and surgery for oesophageal cancer

“…Most survival rates reported in the literature are static, being calculated from the day of diagnosis or surgery. However, the risk of death changes with time after surgery.…”