Short- and medium-term prognosis of Takotsubo syndrome in a Portuguese population

Bento, Dina; Azevedo, Olga; Santos, Rui Pontes dos; Almeida, Ana Rita; Domingues, Kevin; Marmelo, Bruno; Reis, Liliana; Ruivo, Catarina; Guerreiro, Rui Azevedo; Lima, Rui; Faria, Ricardo; Marreiros, Ana; Marques, Nuno

doi:10.1016/j.repc.2018.07.010

Cited by 20 publications

(17 citation statements)

References 42 publications

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“…In a retrospective study of 61 TCM patients, CKD‐TCM patients were more likely to have inpatient complications, including all‐cause mortality and severe pump failure, than non‐CKD‐TCM patients (HR:2.49, 95%CI:1.01–5.98) 37 . A multicenter observational study also showed that CKD was an independent predictor of hospital complications, such as acute heart failure and atrial fibrillation, in TCM (OR:7.99, 95%CI:1.39–45.79, p = .02) 38 . Another retrospective study of 24 595 TCM patients suggested that TCM patients with advanced CKD had a higher risk of acute kidney injury (AKI) (44.96% vs. 22.73%, p < .0001).…”

Section: Resultsmentioning

confidence: 96%

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Liang

Zhang

et al. 2021

Clinical Cardiology

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Takotsubo cardiomyopathy (TCM), characterized by transient left ventricular dysfunction, was first reported in Japan in 1990. Current research suggests that TCM can be affected by conventional cardiovascular factors such as hypertension (HTN), diabetes, hyperlipidemia (HLD), and obesity. Despite the increasing interest in this disease, research on TCM remains limited. Conventional cardiovascular factors are clinically related to the outcome of TCM. We reviewed the publications published in PubMed database between January 01 2010 and January 15 2021, and summarized the most current available evidence on the correlation between TCM and the conventional cardiovascular factors. TCM patients are predominantly postmenopausal women. Men and young patients are less commonly seen, but are prone to acute adverse complications and poor prognosis. HTN is common in patients with recurrent TCM. Existing evidence suggests that obesity and chronic kidney disease are related to poor prognosis in TCM. HLD is reported to be associated with fewer complications, though current evidence is limited. Finally, the relationship between diabetes and TCM prognosis is ambivalent. Current evidence suggests conventional cardiovascular risk factors are associated with the outcome of TCM, especially with mortality and complications. More prospective studies are needed to clarify the relationship between each risk factor and the prognosis of TCM.

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Section: Resultsmentioning

confidence: 96%

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Liang

Zhang

et al. 2021

Clinical Cardiology

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“…Besides, dyspnea itself at presentation has been reported as an independent predictor of in-hospital complications, such as cardiogenic shock, ventricular arrhythmias and all-cause inpatient death, in TCM patients. 13 Excessive catecholamine simulation has been thought to be one of the mechanisms of TCM and has been associated with worse outcomes in TCM patients. Though previous clinical studies yielded inconsistent results regarding the use of β-blockers in TCM patients, Kyuma M reported that intravenous propranolol can relieve the discordant ventricle by antagonizing the activation of sympathetic nerves in patients with significant intraventricular pressure gradient.…”

Section: Discussionmentioning

confidence: 99%

“…6 Many pre-existing factors have been identified that affect the outcomes of TCM include age, 7 sex, 8 race, 9 conventional cardiovascular risk factors (such as obesity, 10 and diabetes mellitus (DM) 11 ), psychiatric disorders (such as anxiety, depression 12 ), and chronic kidney disease (CKD). 13,14 Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death worldwide. 15,16 It is often seen in patients with TCM, with an even higher prevalence in patients with acute coronary syndrome.…”

Section: Introductionmentioning

confidence: 99%

<p>The Impact of COPD on in-Hospital Outcomes in Patients with Takotsubo Cardiomyopathy</p>

Teng

et al. 2020

COPD

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Chronic obstructive pulmonary disease (COPD) is a known comorbidity of takotsubo cardiomyopathy (TCM), and COPD exacerbation is a potential triggering factor of TCM. The association between COPD and in-hospital outcomes and complications among TCM patients is not well established. We sought to assess the effect of COPD on hospitalized patients with a primary diagnosis of TCM. Methods: We conducted a retrospective cohort study in patients with a primary diagnosis of TCM with or without COPD using the latest National Inpatient Sample from 2016-2017. We identified 3139 patients admitted with a primary diagnosis of TCM by the ICD-10-CM coding system; 684 of those patients also had a diagnosis of COPD. We performed propensity score matching in a 1:2 ratio (n=678 patients, matched COPD group; n=1070, matched non-COPD group) and compared in-hospital outcomes and complications between TCM patients with and without a COPD diagnosis. Results: Before matching, the COPD group had worse outcomes compared with the non-COPD group in inpatient death (2.9% vs 1.3%, p=0.006), length of stay (LOS) (4.02±2.99 days vs 3.27±3.39 days, p<0.001), hospitalization charges ($55,242.68±47,637.40 vs $48,316.97±47,939.84, p=0.001), and acute respiratory failure (ARF) (22.5% vs 7.7%, p<0.001), respectively. After propensity score matching, the matched COPD group, compared with the matched non-COPD group, had a higher inpatient mortality rate (2.9% vs1.0%, p=0.005), longer LOS (4.02±3.00 days vs 3.40±3.54 days, p<0.001), higher hospitalization charges ($55,409.23±47,809.13 vs $46,469.60±42,209.10, p<0.001), and a higher incidence of ARF (22.6% vs 8.2%, p<0.001) and cardiogenic shock (5.6% vs 3.3%, p=0.024), respectively. Conclusion: Patients with COPD who are hospitalized for TCM have higher rates of inpatient mortality, ARF, cardiogenic shock, as well as a longer LOS, and higher charges of stay than those without COPD. Prospective studies are warranted to examine the effect of early intervention or treatment of COPD on short-and long-term outcomes of TCM.

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“…J Pinto Monteiro et al 13 KAsH: Uma nova ferramenta para previsão de mortalidade hospitalar em doentes com Enfarte Agudo do Miocárdio https://www.revportcardiol.org/pt-kash-a-new-tool-predict-articulo-S0870255119305785 D Bento et al 16 Prognóstico a curto e médio prazo da síndrome de Takotsubo numa população portuguesa https://www.revportcardiol.org/pt-short-medium-term-prognosis-takotsubo-syndrome-articulo-S0870255118300933 D Bonhorst et al 20 Implantação de dispositivos de ressincronização e/ou desfibrilhação em doentes com insuficiência cardíaca: dados da vida real -o Estudo Síncrone https://www.revportcardiol.org/pt-implantacao-dispositivos-ressincronizacao-e-ou-desfibrilhacao-articulo-S0870255117306893 L Fernandes et al 19 Acidente vascular cerebral isquémico em doentes previamente anticoagulados por fibrilhação auricular não valvular: porque acontece? https://www.revportcardiol.org/pt-acidente-vascular-cerebral-isquemico-em-articulo-S0870255118300155 C Ruivo et al 25 The SHIFT model combines clinical, electrocardiographic and echocardiographic parameters to predict Sudden Cardiac Death in Hypertrophic Cardiomyopathy A Sousa et al 23 Caracterização molecular dos doentes portugueses com miocardiopatia dilatada https://www.revportcardiol.org/pt-molecular-characterization-portuguese-patients-with-articulo-S0870255118302269 C Ruivo et al 22 Myocardial deformation measures by cardiac magnetic resonance tissue tracking in myocarditis: relationship with systolic function and myocardial lesion…”

Section: Prevenção Cardiovascularunclassified

“…15 Este ano, foram publicados na Rev Port Cardiol os resultados de um estudo multicêntrico português, que avaliou as características de 234 doentes com esse diagnóstico. 16 Nesse artigo, mostrou-se que, em geral, essa síndrome tem um bom prognóstico a curto e a médio prazo (mortalidade intra-hospitalar de 2,2%), mas que a taxa de complicações intra-hospitalares (nomeadamente insuficiência cardíaca, fibrilação atrial, arritmias ventriculares e AVC) ainda é elevada (33%).…”

Section: Doença Coronariana Crônica E Síndromes Coronarianas Agudasunclassified

Os Top 10 Artigos Originais Publicados nos Arquivos Brasileiros de Cardiologia e na Revista Portuguesa de Cardiologia em 2019

et al. 2020

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Short- and medium-term prognosis of Takotsubo syndrome in a Portuguese population

Cited by 20 publications

References 42 publications

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

Conventional cardiovascular risk factors associated with Takotsubo cardiomyopathy: A comprehensive review

<p>The Impact of COPD on in-Hospital Outcomes in Patients with Takotsubo Cardiomyopathy</p>

Os Top 10 Artigos Originais Publicados nos Arquivos Brasileiros de Cardiologia e na Revista Portuguesa de Cardiologia em 2019

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