Short and Prolonged Periods of Maternal Separation and Voluntary Ethanol Intake in Male and Female Ethanol-Preferring AA and Ethanol-Avoiding ANA Rats

Roman, Erika; Gustafsson, Lisa; Hyytiä, Petri; Nylander, Ingrid

doi:10.1097/01.alc.0000158933.70242.fc

Cited by 51 publications

(45 citation statements)

References 81 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, peer rearing in nonhuman primates consistently leads to elevated alcohol consumption in adulthood compared with mother-reared conspecifics (Higley et al, 1991;Fahlke et al, 2000;Huggins et al, 2012). In agreement with these findings, maternal separation in rodents is known to induce persistent increases in alcohol consumption in adulthood (Roman et al, 2005;Cruz et al, 2008;Nylander and Roman, 2013). Furthermore, postweaning isolation rearing in rodents has repeatedly been shown to result in augmented alcohol consumption and operant responding for alcohol in adulthood (Ellison, 1981;Schenk et al, 1990;Wolffgramm, 1990;Hall et al, 1998;Lodge and Lawrence, 2003;Advani et al, 2007;Deehan et al, 2007;McCool and Chappell, 2009;Sanna et al, 2011;Chappell et al, 2013;Butler et al, 2014).…”

Section: Introductionmentioning

confidence: 60%

Early social isolation augments alcohol consumption in rats

Lesscher

Spoelder

Rotte

et al. 2015

Behavioural Pharmacology

View full text Add to dashboard Cite

There is a considerable degree of individual vulnerability for alcohol use disorder (AUD) as only a subpopulation of individuals who regularly consume alcohol develop AUD. It is therefore very important to understand the factors and mechanisms that contribute towards the individual risk for AUD. In this respect, social influences, in particular during development, may be relevant for AUD as disruptions in early social experiences are associated with an increased risk for AUD. Social play, the most prominent form of social behaviour shown by young mammals, is rewarding and considered to be important for social, emotional and cognitive development. Recent studies suggest that early social isolation, effectively depriving animals from social play, increases the risk for addictive behaviour. The aim of this study was therefore to explore the long-term consequences of early social isolation on alcohol consumption and motivation for alcohol. To this end, rats were socially isolated from postnatal days 21-42, followed by 4 weeks of social housing, and voluntary alcohol consumption and operant responding for alcohol were determined in adulthood. We observed enhanced levels of alcohol consumption in adulthood in previously isolated rats, whereas operant responding for alcohol was not altered. The impact of early social isolation was independent of the individual variation in alcohol consumption. These data indicate that social isolation, during a developmental period when social play is highly abundant, enhances the propensity to consume alcohol in adulthood. This implies that early social experience may be a protective factor against excessive alcohol use.

show abstract

Section: Introductionmentioning

confidence: 60%

Early social isolation augments alcohol consumption in rats

Lesscher

Spoelder

Rotte

et al. 2015

Behavioural Pharmacology

View full text Add to dashboard Cite

show abstract

“…Maternal separation generally increases voluntary consumption of alcohol at moderate to relatively high doses (8-10% solutions), but the effects depend on strain and gender (Huot et al, 2001;Roman et al, 2005;Cruz et al, 2008). Ethanol-induced behavioural sensitisation is another effect of maternal separation, serving as model of vulnerability for drug abuse (Kawakami et al, 2007).…”

Section: Maternal Care and The Reward Systemmentioning

confidence: 99%

Brain development under stress: Hypotheses of glucocorticoid actions revisited

Oitzl

Champagne

Veen

et al. 2010

Neuroscience & Biobehavioral Reviews

323

218

View full text Add to dashboard Cite

“…The test should be of a sufficient time length (5-10 and even more minutes), especially if the subject moves slowly, to compensate for random errors (Nomura, 1980;Fan et al, 2005;Lind et al, 2005). However, it is inappropriate to test neonates with a long separation from the dam because of its possible influence on the behavior of offsprings (Roman et al, 2005).…”

Section: Introductionmentioning

confidence: 99%