Short communication: Distribution of Porphyromonas gulae fimA genotypes in oral specimens from dogs with mitral regurgitation

Shirai, Mitsuyuki; Nomura, Ryota; Kato, Yukio; Murakami, Masaru; Kondo, Chihiro; Takahashi, Soraaki; Yamasaki, Yoshie; Matsumoto‐Nakano, Michiyo; Arai, Nobuaki; Yasuda, Hidemi; Nakano, Kazuhiko; Asai, Fumitoshi

doi:10.1016/j.rvsc.2015.07.009

Cited by 8 publications

(8 citation statements)

References 16 publications

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“…Periodontal disease is extremely common in dogs and is associated with serious systemic diseases (1)(2)(3)(4)(5)(6). Studies have reported that 84% of Beagles over the age of 3 and 100% of Poodles over the age of 4 develop periodontal disease (5)(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Shirahata

Iwashita²,

Sasaki³

et al. 2023

Front. Vet. Sci.

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Previous research has demonstrated that Porphyromonas gulae (P. gulae) significantly contributes to the development of periodontal disease in dogs. Porphyromonas gulae is divided into three subtypes according to the 41-kDa filamentous appendage (fimA), defined as types A, B, and C. This study aimed to elucidate the association between fimA type of P. gulae with the number of permanent teeth, reflecting the severity of periodontal disease. Two hundred twenty-five dogs were categorized by P. gulae fimA type as negative, type A dominant, type B dominant, and type C dominant. The stage of periodontal disease in P. gulae-positive dogs increased with age, particularly in type C dominant dogs. Correspondingly, the number of permanent teeth in P. gulae fimA type C-dominant dogs was significantly lower than that of P. gulae-negative dogs, suggesting there is a significant association between fimA type of P. gulae and the number of permanent teeth resulting from the development of periodontal disease.

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Section: Introductionmentioning

confidence: 99%

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Shirahata

Iwashita²,

Sasaki³

et al. 2023

Front. Vet. Sci.

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“…pylori at levels of more than 1.0 × 10 2 –1.0 × 10 3 CFU in 1 mL saliva, or in the saline rinse of an extracted tooth. Based on the information from the previous analysis 9 , we performed nested PCR using serially diluted bacterial DNA, as in our previous studies 9,41 ; this enabled determination of the approximate numbers of H . pylori in oral specimens.…”

Section: Methodsmentioning

confidence: 99%

Potential involvement of Helicobacter pylori from oral specimens in overweight body-mass index

Hamada

Nomura

Ogaya

et al. 2019

Sci Rep

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The bacterium Helicobacter pylori was originally classified in the Campylobacter genus, which contains major periodontopathic bacterial species, and H. pylori DNA has been found in the oral cavity. Although many studies show an association between the presence of periodontal bacteria and an overweight body-mass index (BMI; >25 kg/m2), the relationship between body weight and the presence of H. pylori in the oral cavity has not been demonstrated. Herein, we analysed the relationship between H. pylori in the oral cavity and systemic conditions, including the overweight BMI. Saliva specimens and extracted teeth were obtained from 87 subjects; the distribution of H. pylori among these specimens was analysed with the polymerase chain reaction. Subjects with an overweight BMI exhibited significantly higher detection rates of H. pylori in saliva, compared with non-overweight subjects (BMI <25 kg/m2) (P < 0.05). A clinical history of digestive diseases was not associated with the presence of H. pylori in overweight subjects, whereas subjects with both severe dental caries and an overweight BMI showed a higher detection rate of H. pylori in saliva specimens, compared with other groups. These results suggest that the detection of H. pylori in the oral cavity could be associated with the overweight BMI, which was predominant among subjects with severe dental caries.

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“…As a result, healthy periodontal tissue is lost, resulting in mobility and loss of teeth 3 . Chronic periodontitis is also associated with systemic disease 5 .…”

Section: Introductionmentioning

confidence: 99%

Investigation of periodontal disease development and Porphyromonas gulae FimA genotype distribution in small dogs

Yasuda,

Nomura

et al. 2024

Sci Rep

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In dogs, Porphyromonas gulae is a major periodontal pathogen with 41-kDa proteins polymerizing to form a filamentous structure called fimbriae or pili, termed FimA. FimA is classified into three genotypes: A, B, and C, and there are combinations of types A, B, C, A/B, A/C, B/C, and A/B/C. Periodontal disease is the most common oral disease in small dogs, but the periodontal disease status and P. gulae colonization at each dog age and breed remain unclear. In this study, we stratified 665 small dogs and analyzed the periodontal status and distribution of P. gulae with each FimA genotype. Dogs with periodontal disease and FimA genotype tended to increase with age. The dogs with at least one FimA genotype had significantly more severe periodontal disease compared with P. gulae-negative dogs (P < 0.01). Additionally, periodontal status was significantly associated with specific FimA genotype distribution in Toy Poodles and Chihuahuas (P < 0.05), whereas there was no such association in Dachshunds. These results suggest that the onset of periodontal disease and P. gulae colonization are related and progress with age. The relationship between periodontal disease and FimA genotype may differ depending on the dog breeds.

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Short communication: Distribution of Porphyromonas gulae fimA genotypes in oral specimens from dogs with mitral regurgitation

Cited by 8 publications

References 16 publications

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Possible association of fimA genotype of Porphyromonas gulae with the severity of periodontal disease and the number of permanent teeth in dogs

Potential involvement of Helicobacter pylori from oral specimens in overweight body-mass index

Investigation of periodontal disease development and Porphyromonas gulae FimA genotype distribution in small dogs

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