Short communication: Effect of conjugated linoleic acid on concentrations of fat-soluble vitamins in milk of lactating ewes

Zeitz, Johanna O.; Most, Erika; Eder, Klaus

doi:10.3168/jds.2014-9218

Cited by 4 publications

(5 citation statements)

References 27 publications

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“…As milk is the only source of nutrient supply for suckling offspring, the finding of similar milk vitamin A concentrations also fits to the observation that tissue vitamin A status of the 7‐ and 14‐day‐old pups was similar in both groups. Our observations, however, are in contrast to studies in cows and ewes, which found increased milk retinol concentrations in response to CLA feeding (Gessner et al., ; Zeitz et al., ). The reasons for this discrepancy are unknown, but may be related to the animal species.…”

Section: Discussioncontrasting

confidence: 99%

“…For example, CLA reduces the expression of genes involved in lipid synthesis and uptakes and influences fatty acid (FA) composition in body tissues (Ringseis et al., ). In lactating dairy cows and ewes, it was recently found that dietary CLA increases vitamin A concentrations in the milk (Gessner et al., ; Zeitz, Most, & Eder, ). This observation suggests that dietary CLA influences vitamin A metabolism during lactation.…”

Section: Introductionmentioning

confidence: 99%

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Effect of dietary conjugated linoleic acid on vitamin A status of lactating rats and their offspring

Zeitz

Most

Eder

2017

Animal Physiology Nutrition

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SummaryThe absorption and metabolism of vitamin A is linked with that of lipids. It is known that conjugated linoleic acid (CLA) affects the lipid metabolism in growing and lactating animals. In the present study, the hypothesis was investigated that dietary CLA influences vitamin A status of lactating rats and their pups during the suckling period.For this purpose, Wistar Han rats were fed either a control diet (control group, n = 14) or a diet containing 0.87% of cis-9, trans-11 and trans-10, cis-12 (1:1) CLA (CLA group, n = 14) during pregnancy and lactation. Vitamin A concentrations in various body tissues were determined 14 days after delivery in dams and 1, 7 and 14 days after birth in pups, and expression of selected genes involved in metabolism of retinoids was determined in dams. Vitamin A concentrations in liver, plasma and muscle were similar in control and CLA-fed dams. Expression of genes involved in retinoid transport, storage and degradation in liver and adipose tissue in dams was also not different between control and CLA-fed dams. Vitamin A concentrations in milk curd, sampled at d 1, 7 and 14 of lactation were not different between control and CLA-fed dams. Vitamin A concentrations in liver, lung and adipose tissue were also not different in pups from control dams and pups from CLA-fed dams. In conclusion, we show for the first time that dietary CLA has little effect on vitamin A concentrations and vitamin A metabolism in lactating rat dams and, moreover, does not influence tissue vitamin A concentrations in their newborn and suckling pups. K E Y W O R D Sconjugated linoleic acid, lactating rat, retinol, vitamin status

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of dietary conjugated linoleic acid on vitamin A status of lactating rats and their offspring

Zeitz

Most

Eder

2017

Animal Physiology Nutrition

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“…Generally, our results for retinol and tocopherol in milk are in line with literature (Calderon, Chauveau‐Duriot, Martin et al., ; Calderon, Chauveau‐Duriot, Pradel et al., ; Gessner et al., ; Zeitz et al., ). Similar to Gessner et al.…”

Section: Discussionsupporting

confidence: 93%

“…E has been shown to be an important antioxidant, which might not only influence milk quality by protecting polyunsaturated fatty acids from oxidation but also increase the antioxidant capacity of the cow itself (Burton & Traber, ). Zeitz, Most, and Eder () have proven that supplementation with CLA increased the milk concentration of Vit. E as well as retinol in ewes when related to milk fat content.…”

Section: Introductionmentioning

confidence: 99%

Influence of conjugated linoleic acids and vitamin E on milk fatty acid composition and concentrations of vitamin A and α‐tocopherol in blood and milk of dairy cows

Schäfers

Meyer

Soosten

et al. 2017

Animal Physiology Nutrition

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SummaryThe objective of this trial was to investigate the influences of conjugated linoleic acid (CLA) and vitamin E (Vit. E) and their interactions on fatty acid composition and vitamins in milk (α-tocopherol, retinol and β-carotene) as well as on α-tocopherol in blood of pluriparous cows from week 6 ante partum until week 10 post-partum (p.p.). We assigned 59 pluriparous German Holstein cows to four treatment groups with the treatment factors CLA and Vit. E at two levels in a 2 × 2 factorial design. Milk fatty acid composition and milk vitamins were analysed on lactation days 7 and 28. α-tocopherol in blood serum was analysed on days −42, −7, 1, 7, 14, 28 and 70 relative to parturition. Milk concentration of α-tocopherol was influenced by Vit. E (p < .001) and CLA (p = .034). Percentage of cis-9, trans-11 CLA in total milk fat was influenced by treatment with CLA (p < .001), while for percentage of trans-10, cis-12 CLA an interaction between treatment and day (p = .019), driven by an increase in both CLA groups from day 7 to day 28, was found. Serum ratios of α-tocopherol to cholesterol were influenced by Vit. E (p < .001). Results suggest that treatment with CLA during late pregnancy and early lactation is suitable to enhance the proportion of trans-10, cis-12 CLA in milk and thereby influencing nutritional properties. As treatment with Vit. E did not have an impact on milk fatty acid composition, it might be possible to increase the antioxidative capacity of the dairy cow without affecting milk properties. Consequently, combined treatment with CLA and Vit. E might elicit synergistic effects on the cow and milk quality by increasing the proportion of CLA in milk fat as well as the excretion of Vit. E and the Vit. E levels in serum. K E Y W O R D Sconjugated linoleic acid, dairy cow, milk fatty acids, vitamin A, vitamin E

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“…Some studies have shown the protective effects of CLA isomers against oxidative stress and lipid peroxidation in animal models (Andreoli et al, 2010;Chinnadurai et al, 2013). Gessner et al (2015) in cows, and in dairy ewes, Zeitz et al (2015) demonstrated significantly higher vitamin E and A concentrations in milk from CLA-supplemented animals. Changes in the oxidative metabolism occur in the transition period of dairy cows, and several studies have suggested that oxidative stress increases the susceptibility of dairy cattle to diseases (Bernabucci et al, 2005;Castillo et al, 2005;Sordillo and Aitken, 2009).…”

Section: Introductionmentioning

confidence: 99%

Comparison between conjugated linoleic acid and essential fatty acids in preventing oxidative stress in bovine mammary epithelial cells

Basiricò

Morera

Dipasquale

et al. 2017

Journal of Dairy Science

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Some in vitro and in vivo studies have demonstrated protective effects of conjugated linoleic acid (CLA) isomers against oxidative stress and lipid peroxidation. However, only a few and conflicting studies have been conducted showing the antioxidant potential of essential fatty acids. The objectives of the study were to compare the effects of CLA to other essential fatty acids on the thiol redox status of bovine mammary epithelia cells (BME-UV1) and their protective role against oxidative damage on the mammary gland by an in vitro study. The BME-UV1 cells were treated with complete medium containing 50 μM of cis-9,trans-11 CLA, trans-10,cis-12 CLA, α-linolenic acid, γ-linolenic acid, and linoleic acid. To assess the cellular antioxidant response, glutathione, NADPH, and γ-glutamyl-cysteine ligase activity were measured 48 h after addition of fatty acids (FA). Intracellular reactive oxygen species and malondialdehyde production were also assessed in cells supplemented with FA. Reactive oxygen species production after 3 h of HO exposure was assessed to evaluate and to compare the potential protection of different FA against HO-induced oxidative stress. All FA treatments induced an intracellular GSH increase, matched by high concentrations of NADPH and an increase of γ-glutamyl-cysteine ligase activity. Cells supplemented with FA showed a reduction in intracellular malondialdehyde levels. In particular, CLA isomers and linoleic acid supplementation showed a better antioxidant cellular response against oxidative damage induced by HO compared with other FA.

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Short communication: Effect of conjugated linoleic acid on concentrations of fat-soluble vitamins in milk of lactating ewes

Cited by 4 publications

References 27 publications

Effect of dietary conjugated linoleic acid on vitamin A status of lactating rats and their offspring

Effect of dietary conjugated linoleic acid on vitamin A status of lactating rats and their offspring

Influence of conjugated linoleic acids and vitamin E on milk fatty acid composition and concentrations of vitamin A and α‐tocopherol in blood and milk of dairy cows

Comparison between conjugated linoleic acid and essential fatty acids in preventing oxidative stress in bovine mammary epithelial cells

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