Short Communication Implications of <i>GSTM1</i>, <i>GSTT1</i>, and <i>GSTP1</i> polymorphisms for susceptibility to chronic lymphocytic leukemia

Abstract

possible genetic associations between GSTM1/GSTT1 deletion and GSTP1 rs1695 polymorphisms with CLL risk in a central Brazilian population. For GSTM1/GSTT1 deletion polymorphism, genotyping was performed with multiplex real-time PCR (qPCR), and for GSTP1 rs1695 polymorphism, PCR-RFLP was used. The GSTM1 null genotype presented a trend towards CLL risk. However, GSTT1 deletion polymorphism presented a protective effect for CLL (OR=0.26, p<0.005).The GSTP1 rs1695 was not associated with disease susceptibility. Among confounding factors, male gender and age was associated with a 2.42-fold and 1.06-fold increased risk of CLL, respectively. In conclusion, among the polymorphisms that were evaluated, the GSTM1 deletion polymorphism apparently helpsin the detoxification process and has a protective effect against CLL.

Research Article <i>GSTM1</i>/<i>GSTT1</i>-null genotyping role in leukemia development in Brazilian patients

“…Scientific reports regarding glutathione S-transferases genetic in the leukemia context of Brazilian population are few, however some examples chase for GSTM1 and GSTT1 influence in cancer. Cancer development is linked to an imbalance between cellular detoxification enzymatic system and exposure to carcinogenic agents, where glutathione S-transferases system present an essential role (Reis et al 2021). A classical Brazilian report showed that GSTM1 and GSTT1-null frequency between different Brazilian ethnicities are linked to carcinogenesis (Arruda et al, 1998).…”

“…A report demonstrated that GSTM1 and GSTT1 null genotypes were higher in cases than in controls and there was evidence of a trend in increasing risk with the number of putative "high-risk" alleles of the GST family carried (Yuille et al 2002;Lordelo et al 2012). A recent data suggest that GSTT1 positive genotype may represent a protective effect over CLL, however highlighting bias because ethnic heterogeneity in Brazilian population (Reis et al, 2021). A Russiona study demonstrated that the combination of unfavorable polymorphic CYP1A1 variants and GSTM1 null genotype was found more frequently in B-CLL patients relative to controls (Gra et al 2008).…”

“…Glutathione peroxidases are part of a group of enzymes whose main biological functions involve protecting the body against oxidative stress, which is caused by excess reactive oxygen species, leading to irreversible damage in the membranes, DNA or proteins (Wei et al, 2020;Reis et al, 2021). The main players of the Glutathione family are GSTM1, GSTT1 and GSTP1 (Liu et al, 2017).…”