Short communication: The mammalian lignan enterolactone is absorbed by newborn dairy calves fed enterolactone-enriched milk

Ghedini, Caren Paludo; Whitehouse, N.L.; Moura, Daiane Caroline de; Oliveira, André Soares de; Brito, A.F.

doi:10.3168/jds.2017-13093

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…In addition, poor colostrum quality is associated with low concentration of antioxidants (Maciej et al, 2015), suggesting that feeding EL-enriched milk to newborn and preweaned calves may be a viable strategy to mitigate oxidative stress. Ghedini et al (2017 The mammalian lignan enterolactone is absorbed by newborn dairy calves fed enterolactoneenriched milk C.P. Ghedini,* N.L.…”

Section: Absorption Of Flax Antioxidants and Transfer In Milkmentioning

confidence: 99%

Perspectivas e desafios para a produção de leite e carne no cerrado

Dias¹,

Santos²,

Ítavo³

et al. 2020

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Section: Absorption Of Flax Antioxidants and Transfer In Milkmentioning

confidence: 99%

Perspectivas e desafios para a produção de leite e carne no cerrado

Dias¹,

Santos²,

Ítavo³

et al. 2020

View full text Add to dashboard Cite

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“…sociated with reduced risks of colorectal adenoma (Kuijsten et al, 2006), acute coronary events (Vanharanta et al, 1999), and deaths related to cardiovascular disease (Vanharanta et al, 2003). The mammalian lignan could be well absorbed by dairy calves when fed with EL-enriched milk, suggesting that humans may also get potential health benefits by consuming milk enriched with mammalian lignans (Ghedini et al, 2017). Quantification of mammalian lignans in livestock milk and plasma is thus important to monitor the quality of livestock products.…”

mentioning

confidence: 99%

Technical note: Quantification of lignans in the urine, milk, and plasma of flaxseed cake–fed dairy sheep

Zhuang

et al. 2021

Journal of Dairy Science

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Mammalian lignans are phytoestrogens with important bioactivities, and their concentrations in livestock milk may influence the health of consumers. This research aimed to establish a method to quantify multiple mammalian lignans in the biofluids of dairy sheep using ultra-HPLC-triple quadropole mass spectrometry with multiple-reaction monitoring. Secoisolariciresinol, 2-[(4-hydroxy-3-methoxyphenyl) methyl]-3-[(3-hydroxyphenyl)methyl]-1,4-butanediol, enterodiol (ED), enterolactone (EL), ED-sulfate (ED-S), and EL-sulfate (EL-S) were purified from the urine of flaxseed cake-fed dairy sheep. The structures of these lignans were identified by a combination of mass and nuclear magnetic resonance spectra. These purified lignans were used as standards to optimize their quantification conditions in urine, milk, and plasma of dairy sheep. On this basis, the lignan metabolites in biofluids were quantified. To improve analysis sensitivity, plasma and milk were pretreated with acetonitrile containing 1% formic acid and passed through a HybridSPE-PL 55261-U column (Supelco, Bellefonte, PA). The limit of quantification of the lignans ranged from 1.43 to 18.3 ng/mL in plasma, and from 1.01 to 18.7 ng/mL in milk. The linearity of the calibration curves ranged from their limit of quantification to at least 217 ng/mL in plasma, and 217 ng/mL in milk. Regression coefficient of the calibration curves were above 0.99 for secoisolariciresinol, 2-[(4-hydroxy-3-methoxyphenyl)methyl]-3-[(3hydroxyphenyl)methyl]-1,4-butanediol, ED, EL, ED-S, and EL-S, indicating satisfactory relationships between the peak areas and concentrations in the quantification range. The relative concentrations of ED-glucuronide and EL-glucuronide (EL-G) in different biofluids were compared based on their chromatogram peak areas. The sheep plasma contained all forms of mammalian lignans (i.e., ED, EL, ED-S, EL-S, ED-glucuronide, and EL-G.); the urine contained ED, EL, ED-S, and EL-S; and the milk contained ED, EL, ED-S, EL-S, and EL-G. Milk-to-plasma concentration ratios of the mammalian lignans indicated that the free forms were more permeable than the sulfated conjugates. Mammalian lignans found in sheep plasma and milk may provide health benefits to the sheep and sheep-product consumers. The analytical method established in this work could be used to quantify mammalian lignans in livestock products.

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Dietary secoisolariciresinol diglucoside crude extract improves growth through modulating rumen bacterial community and epithelial development in lambs

Liu,

Yu,

et al. 2024

J Sci Food Agric

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BACKGROUNDFlaxseed lignans, types of polyphenolic compounds, primarily consist of secoisolariciresinol diglucoside (SDG). Natural plant extracts are becoming increasingly important as feed for ruminant animals. An underutilized plant bioactive component, SDG shows promising benefits for young ruminant production. The objective of this study was to assess the impact of SDG on rumen fermentation using an in vitro rumen simulation technology. Additionally, we tested the effects of SDG (0.20 g kg−1 body weight) on rumen development and production performance of lambs in a production setting.RESULTSThe in vitro addition of 100 mg L−1 SDG demonstrated significant regulatory effects, with a notable decrease in the acetate/propionate ratio (P < 0.05). Feeding trials revealed that SDG significantly increased average daily feed intake and average daily weight gain (P < 0.05), and reduced the acetate/propionate ratio (P < 0.05). This led to a significant increase in the relative abundance of Eubacterium ruminantium (P = 0.038) and Butyrivibrio (P = 0.002). Furthermore, it promoted rumen development and upregulated the relative expression of mRNA of Cyclin E1 and CDK2 in rumen epithelial cells (P < 0.05).CONCLUSIONThe SDG extract optimizes the composition of rumen microbiota and the development of rumen epithelial cells, promoting the growth of pre‐weaning lambs. The SDG additive exhibits potential as a novel growth promoter for ruminant animals, offering a promising solution for sustainable livestock production. © 2024 Society of Chemical Industry.

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Short communication: The mammalian lignan enterolactone is absorbed by newborn dairy calves fed enterolactone-enriched milk

Cited by 6 publications

References 26 publications

Perspectivas e desafios para a produção de leite e carne no cerrado

Perspectivas e desafios para a produção de leite e carne no cerrado

Technical note: Quantification of lignans in the urine, milk, and plasma of flaxseed cake–fed dairy sheep

Dietary secoisolariciresinol diglucoside crude extract improves growth through modulating rumen bacterial community and epithelial development in lambs

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