Short-course chemotherapy for tuberculosis of the spine

Parthasarathy, R; Sri-Ram, Kesavan; Santha, T; Prabhakar, R; Somasundaram, P. R.; Sivasubramanian, S

doi:10.1302/0301-620x.81b3.0810464

Cited by 44 publications

(3 citation statements)

References 10 publications

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“…The spine constitutes almost 50% of the osteoarticular tuberculosis [13], usually presenting with a spine deformity such as kyphosis, neurological deficit and even paraplegia [8,25]. Antituberculosis chemotherapy is very important to cure the disease and prevent recurrence [18]. It should be emphasised that surgery cannot replace chemotherapy in managing spinal tuberculosis [15].…”

Section: Discussionmentioning

confidence: 99%

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One-stage surgical management for children with spinal tuberculosis by anterior decompression and posterior instrumentation

Huang

Chen

et al. 2009

International Orthopaedics (SICOT)

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The goal of this study was to assess the efficacy of one-stage surgical management for children with spinal tuberculosis by anterior decompression, bone grafting, posterior instrumentation, and fusion. Between January 2002 and December 2006, 15 cases with spinal tuberculosis were treated with one-stage posterior internal fixation and anterior debridement. All cases were followed-up for an average of 30.3 months (range 12-48 months). The average neurological recovery in the patients was 0.93 grades on the scale of Frankel et al. (Paraplegia 7:179-192, 1969). The average preoperative kyphosis was 36 degrees (range 19-59 degrees ), and the average postoperative kyphosis was 23 degrees (range 15-38 degrees ) at final follow-up. At final follow-up, minimal progression of kyphosis was seen, with an average kyphosis of 27 degrees (range 16-40 degrees ). An average loss of correction of 4 degrees was seen at final follow-up. One-stage surgical management for children with spinal tuberculosis by anterior decompression, bone grafting, posterior instrumentation, and fusion was feasible and effective.

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Section: Discussionmentioning

confidence: 99%

“…There is a wide spectrum of treatment options available for children with tuberculosis. A judicious use of conservative therapy and operative decompression when indicated is the usual management [18].…”

Section: Discussionmentioning

confidence: 99%

One-stage surgical management for children with spinal tuberculosis by anterior decompression and posterior instrumentation

Huang

Chen

et al. 2009

International Orthopaedics (SICOT)

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“…Early diagnosis is important for treatment. The standard combination therapy using Rifampicin, Ethambutol, Isoniazid, and Pyrazinamide for two months followed by Isoniazid and Rifampicin for 6 months is the most recommended treatment [ 8 , 10 , 17 , 18 ]. Medical management has been shown to improve the pain symptoms in most patients and has shown that ESR and C-reactive protein will level off over time [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

Diagnosis, Management, and Prognosis of Spinal Tuberculosis: A Case Report

Talebzadeh¹,

Talebzadeh

2023

Cureus

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Routine surgery in addition to chemotherapy for treating spinal tuberculosis

Jutte

Loenhout-Rooyackers²

2006

Cochrane Database of Systematic Reviews

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The two included trials had too few participants to be able to say whether routine surgery might help. Although current medication and operative techniques are now far more advanced, these results indicate that routine surgery cannot be recommended unless within the context of a large, well-conducted randomized controlled trial. Clinicians may judge that surgery may be clinically indicated in some groups of patients. Future studies need to address these topics as well as the patient's view of their disease and treatment.

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Short-course chemotherapy for tuberculosis of the spine

Cited by 44 publications

References 10 publications

One-stage surgical management for children with spinal tuberculosis by anterior decompression and posterior instrumentation

One-stage surgical management for children with spinal tuberculosis by anterior decompression and posterior instrumentation

Diagnosis, Management, and Prognosis of Spinal Tuberculosis: A Case Report

Routine surgery in addition to chemotherapy for treating spinal tuberculosis

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