Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest

Yu, Tao; Yang, Zhengfei; Li, Heng; Ding, Youde; Huang, Zitong; Li, Yongqin

doi:10.1155/2015/279192

Cited by 6 publications

(4 citation statements)

References 28 publications

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“…A similar study found that 7/7 (100%) pigs fully recovered if they were cooled to 32–34°C within 2 hours of return of spontaneous circulation (ROSC) and maintained in that range for 4 hours (Yu et al , 2015). Only 3/7 (43%) control animals that were maintained at normothermia in this study survived 4 days.…”

Section: Introductionmentioning

confidence: 95%

Time to Cooling Is Associated with Resuscitation Outcomes

Schock

Janata

Peacock

et al. 2016

Therapeutic Hypothermia and Temperature Management

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Our purpose was to analyze evidence related to timing of cooling from studies of targeted temperature management (TTM) after return of spontaneous circulation (ROSC) after cardiac arrest and to recommend directions for future therapy optimization. We conducted a preliminary review of studies of both animals and patients treated with post-ROSC TTM and hypothesized that a more rapid cooling strategy in the absence of volume-adding cold infusions would provide improved outcomes in comparison with slower cooling. We defined rapid cooling as the achievement of 34°C within 3.5 hours of ROSC without the use of volume-adding cold infusions, with a ≥3.0°C/hour rate of cooling. Using the PubMed database and a previously published systematic review, we identified clinical studies published from 2002 through 2014 related to TTM. Analysis included studies with time from collapse to ROSC of 20–30 minutes, reporting of time from ROSC to target temperature and rate of patients in ventricular tachycardia or ventricular fibrillation, and hypothermia maintained for 20–24 hours. The use of cardiopulmonary bypass as a cooling method was an exclusion criterion for this analysis. We compared all rapid cooling studies with all slower cooling studies of ≥100 patients. Eleven studies were initially identified for analysis, comprising 4091 patients. Two additional studies totaling 609 patients were added based on availability of unpublished data, bringing the total to 13 studies of 4700 patients. Outcomes for patients, dichotomized into faster and slower cooling approaches, were determined using weighted linear regression using IBM SPSS Statistics software. Rapid cooling without volume-adding cold infusions yielded a higher rate of good neurological recovery than slower cooling methods. Attainment of a temperature below 34°C within 3.5 hours of ROSC and using a cooling rate of more than 3°C/hour appear to be beneficial.

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Section: Introductionmentioning

confidence: 95%

Time to Cooling Is Associated with Resuscitation Outcomes

Schock

Janata

Peacock

et al. 2016

Therapeutic Hypothermia and Temperature Management

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“…From the physiological point of view, brain temperature should be the priority monitoring site for survivors with TTM. With the fact that the jugular bulb blood is derived from intracerebral vasculature, the jugular vein temperature has been considered as an accurate index of cerebral cortical temperature in various studies [ 8 , 9 ]. However, both brain cortex and jugular vein temperature are not so easily detected and insufficient data of temperature value may lead to delay initiation and insufficient or excessive TTM.…”

Section: Discussionmentioning

confidence: 99%

Is Esophageal Temperature Better to Estimate Brain Temperature during Target Temperature Management in a Porcine Model of Cardiopulmonary Resuscitation?

Yang

Liu

et al. 2017

BioMed Research International

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Brain temperature monitoring is important in target temperature management for comatose survivors after cardiac arrest. Since acquisition of brain temperature is invasive and unrealistic in scene of resuscitation, we tried to sought out surrogate sites of temperature measurements that can precisely reflect cerebral temperature. Therefore, we designed this controlled, randomized animal study to investigate whether esophageal temperature can better predict brain temperature in two different hypothermia protocols. The results indicated that esophageal temperature had a stronger correlation with brain temperature in the early phase of hypothermia in both whole and regional body cooling protocols. It means that esophageal temperature was considered as priority method for early monitoring once hypothermia is initiated. This clinical significance of this study is as follows. Since resuscitated patients have unstable hemodynamics, collecting temperature data from esophagus probe is cost-efficient and easier than the catheter in central vein. Moreover, it can prevent the risk of iatrogenic infection comparing with deep vein catheterization, especially in survivors with transient immunoexpressing in hypothermia protocol.

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“…The ventricular fibrillation ECG data were retrospectively collected from previous studies on mild hypothermia improving CPR in a porcine model. [ 19 ] ECG and blood pressure waveform signals were collected with a Windaq hardware‐/software‐supported data acquisition system (Dataq Instruments Inc., Akron, OH, USA), with a data sampling rate of 300 Hz. The data included the initiation of a model of ventricular fibrillation, the initiation of chest compressions for CPR, and the recovery from successful defibrillation to self‐circulation or the failure of resuscitation.…”

Section: Methodsmentioning

confidence: 99%

Adaptive Recursive Least Squares Denoising in Ventricular Fibrillation ECG Signals

Ding

Yuan

et al. 2023

Advanced Sensor Research

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Cardiac arrest is a fatal and urgent disease in humans. A high‐quality electrocardiogram (ECG) has a positive guide to the success of defibrillation and resuscitation. However, because of artificial motion interference and ambient noise, reliable ECG signals can be obtained only during chest compression (CC) pauses. To address this issue, the adaptive recursive least squares (RLS) denoising approach is proposed. First, the ECG signals of porcine are divided into three groups: CC, without CC, and both with and without CC. Then, five Gaussian noises with different signals‐to‐noise ratios (SNR) and five noises with different distribution types are added, respectively. Furthermore, RLS is compared with six other different denoising approaches. Experimental results demonstrate significant differences between RLS and the other six algorithms in main metrics. SNR and related factors are larger, while the root mean square error is smaller. In conclusion, RLS can significantly eliminate many types of ambient noise, and improve the quality of ECG signals during cardiopulmonary resuscitation.

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Short Duration Combined Mild Hypothermia Improves Resuscitation Outcomes in a Porcine Model of Prolonged Cardiac Arrest

Cited by 6 publications

References 28 publications

Time to Cooling Is Associated with Resuscitation Outcomes

Time to Cooling Is Associated with Resuscitation Outcomes

Is Esophageal Temperature Better to Estimate Brain Temperature during Target Temperature Management in a Porcine Model of Cardiopulmonary Resuscitation?

Adaptive Recursive Least Squares Denoising in Ventricular Fibrillation ECG Signals

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