Short duration therapy for <i>Helicobacter pylori</i> in Western Australia: the impact of metronidazole resistance

Forbes, Geoffrey M; Coombs, Geoffrey W.; Collins, B. J.; Robins, Peter; McCullough, Cheryll

doi:10.1111/j.1445-5994.1998.tb04452.x

Cited by 24 publications

(12 citation statements)

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“…Patients harbouring H. pylori strains resistant to metronidazole had H. pylori cure rates significantly lower than patients with H. pylori metronidazole‐sensitive strains when treated with regimens which included metronidazole (PAM and PCM). These data are in agreement with other studies which demonstrated significantly lower H. pylori cure rates in metronidazole‐resistant patients after treatment with metronidazole in triple therapies which included a proton pump inhibitor and amoxycillin, 12 –17 a proton pump inhibitor and clarithromycin, 14 , 18 , 19 colloidal bismuth subcitrate and amoxycillin, 20 –22 as well as in quadruple therapy with omeprazole, colloidal bismuth subcitrate and tetracycline 23 . In conflict with the present results and with those of the above‐cited reports, 14 , 18 , 19 some studies failed to find a negative influence of metronidazole resistance on the clinical efficacy of a proton pump inhibitor‐based triple therapy which included metronidazole (or tinidazole) in combination with clarithromycin 12 , .…”

Section: Discussionsupporting

confidence: 92%

The effect of antibiotic resistance on the outcome of three 1‐week triple therapies against Helicobacter pylori

Pilotto

Leandro²,

Franceschi

et al. 1999

Aliment Pharmacol Ther

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The cure of Helicobacter pylori infection results in healing of chronic active gastritis and dramatically reduces peptic ulcer relapse rate. The treatment regimens for H. pylori infection currently recommended involve a 1-week triple therapy consisting of a proton pump inhibitor plus two of the following antibiotics: amoxycillin, a nitroimidazole (metronidazole or tinidazole) and clarithromycin. Resistance of H. pylori to the antibiotics included in current therapeutic regimens has been reported as a major reason for treatment failure.2 Therefore, it has been suggested that the selection of antibiotics used in association with proton pump inhibitors for primary treatment of H. pylori infection should be based on the

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Section: Discussionsupporting

confidence: 92%

The effect of antibiotic resistance on the outcome of three 1‐week triple therapies against Helicobacter pylori

Pilotto

Leandro²,

Franceschi

et al. 1999

Aliment Pharmacol Ther

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“…Over recent years, shorter triple therapy protocols have been used with the intention of reducing side‐effects and perhaps increasing compliance with treatment. However, with the increasing incidence of antibiotic resistance [5], it appears that the most practical way of controlling and eliminating H. pylori will be through the development of effective protein‐based vaccines. There is now sufficient experimental data to indicate that this goal is achievable [6].…”

mentioning

confidence: 99%

Proteome Analysis of Highly Immunoreactive Proteins of Helicobacter pylori

et al. 2002

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These results suggest that within a tightly defined region on the H. pylori proteome map there are five groups of proteins that are highly reactive to both IgG and IgA. Our analysis suggests it is unlikely that the highly immunoreactive clusters harbour any significant proteins other than isoforms of HspB, UreB, EF-Tu and FlaA, and that, with the partial exception of FlaA, these clusters are strongly conserved across all seven strains.

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“…O insucesso dos tratamentos endodônticos também tem sido associado à resistência dos micro-organismos patogênicos aos medicamentos utilizados para combatê-los. Esse mecanismo de resistência resulta de alterações fisiológicas ou estruturais da célula bacteriana, que representa uma estratégia de sobrevivência ao ataque abusivo dos agentes antimicrobianos 12 . Estudos têm revelado um aumento surpreendente da resistência antimicrobiana das bactérias que são comumente encontradas nos canais radiculares de dentes com infecção endodôntica.…”

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Avaliação da suscetibilidade antimicrobiana de bactérias anaeróbias facultativas isoladas de canais radiculares de dentes com insucesso endodôntico frente aos antibióticos de uso sistêmico

Santi

Barbosa-Ribeiro

Endo

et al. 2015

Rev. odontol. UNESP

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ResumoIntrodução: Bactérias associadas ao insucesso do tratamento endodôntico são capazes de adquirir e expressar resistência aos agentes antimicrobianos comumente empregados para tratar infecções, o que torna necessário, em determinadas situações, a realização de testes laboratoriais para detectar a resistência ou a suscetibilidade antimicrobiana desses micro-organismos. Objetivo: avaliar a suscetibilidade antimicrobiana das cepas de Enterococcus faecalis, Enterococcus faecium, Actinomyces viscosus e Staphylococcus aureus isoladas de canais radiculares de dentes com insucesso endodôntico. Material e método: Cepas clínicas de Enterococcus faecalis (n=3), Enterococcus faecium (n=3), Actinomyces viscosus (n=3) e Staphylococcus aureus (n=3), coletadas in vivo de canais radiculares com insucesso endodôntico, foram testadas quanto à suscetibilidade antimicrobiana por meio do método E-test em duplicata, utilizando os antibióticos: Amoxicilina (AC), Rifampicina (RI), Moxifloxacina (MX), Vancomicina (VA), Tetraciclina (TC), Ciprofloxacina (CI), Cloranfenicol (CL), Benzilpenicilina (PG), Amoxicilina + ácido clavulânico (XL), Doxiciclina (DC), Eritromicina (EM) e Azitromicina (AZ). Resultado: Todas as cepas clínicas testadas foram suscetíveis aos antibióticos AC, XL, PG, DC, MX, TC e VA. Todos os isolados das espécies de S. aureus foram suscetíveis aos 12 antibióticos testados. As cepas de E. faecalis, E. faecium e A. viscosus mostraram padrão de suscetibilidade intermediário contra EM. Algumas cepas de E. faecalis e E. faecium foram resistentes a AZ e RI. Conclusão: As cepas clínicas isoladas dos canais radiculares de dentes com insucesso endodôntico mostraram perfis diferentes de suscetibilidade antimicrobiana e nenhum isolado de E. faecalis e E. faecium apresentou-se suscetível a AZ e EM.Descritores: Endodontia; bactéria; antibióticos. AbstractIntroduction: Bacteria associated with failure endodontic treatment are capable of acquiring and expressing resistance against antimicrobial agents usually used to treat infections, which makes necessary, in some cases, laboratory tests in order to detect the resistance or antimicrobial susceptibility of these microorganisms. Objective: to evaluate the antimicrobial susceptibility of Enterococcus faecalis, Enterococcus faecium, Actinomyces viscosus and Staphylococcus aureus strains isolated from root canals of teeth with failure endodontic treatment. Material and method: Enterococcus faecalis (n=3), Enterococcus faecium (n=3), Actinomyces viscosus (n=3) and Staphylococcus aureus (n=3) clinical strains collected in vivo from root-filled canals with failure endodontic treatment thad been their antimicrobial susceptibility tested by the E-test method in duplicate using the antibiotics: Amoxicillin (AC), Rifampicin (RI), Moxifloxacin (MX), Vancomycin (VA), Tetracycline (TC), Ciprofloxacin (CI), Chloranphenicol (CL), Benzilpenicillin (PG), Amoxicillin + clavulanic acid (XL), Doxycycline (DC), Erythromycin (EM) e Azithromycin (AZ). Result: all the clinical strains tested were susceptib...

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Short duration therapy for Helicobacter pylori in Western Australia: the impact of metronidazole resistance

Abstract: In Western Australia clearance rates of H. pylori infection, after one week of BTM or LAM, are lower than in other published series. The high incidence of metronidazole resistance is the main determinant of our relatively poor eradication rates.

Cited by 24 publications

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The effect of antibiotic resistance on the outcome of three 1‐week triple therapies against Helicobacter pylori

The effect of antibiotic resistance on the outcome of three 1‐week triple therapies against Helicobacter pylori

Proteome Analysis of Highly Immunoreactive Proteins of Helicobacter pylori

Avaliação da suscetibilidade antimicrobiana de bactérias anaeróbias facultativas isoladas de canais radiculares de dentes com insucesso endodôntico frente aos antibióticos de uso sistêmico

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