Short Leukocyte Telomere Length Predicts Albuminuria Progression in Individuals With Type 2 Diabetes

Gurung, Resham L; Yiamunaa, M; Liu, Sylvia; Liu, Jing; Lim, Su Chi

doi:10.1016/j.ekir.2017.12.005

Cited by 28 publications

(29 citation statements)

References 56 publications

(68 reference statements)

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“…Furthermore, the stronger association of changes in VFA and LTL dynamics than in BMI and LTL, strengthens the link between central obesity and telomere biology. Although we do not have data to infer a relationship between ethnic disparities in obesity‐dependent LTL attrition and susceptibility to diabetes complications, we had previously found that T2D individuals with shorter LTL are at increased risk for albuminuria progression . We postulate that in different ethnicities, LTL attrition driven by changes in adiposity may be weighted differently (ie, mediated by adiposity to a greater degree among Chinese, but less so among Malays and Indians).…”

Section: Discussionmentioning

confidence: 89%

“…Although we do not have data to infer a relationship between ethnic disparities in obesitydependent LTL attrition and susceptibility to diabetes complications, we had previously found that T2D individuals with shorter LTL are at increased risk for albuminuria progression. 21 We postulate that in different ethnicities, LTL attrition driven by changes in adiposity may be weighted differently (ie, mediated by adiposity to a greater degree among Chinese, but less so among Malays and Indians). Whether changes in telomere dynamics explain the ethnic disparities in diabetes complications and mortality in the multiethnic Singapore population warrants further investigation.…”

Section: Discussionmentioning

confidence: 95%

“…The concentration and quality of the DNA were determined using a NanoDrop 1000 spectrophotometer (Thermo Scientific, Wilmington, Delaware). Telomere length at baseline and follow‐up was measured using quantitative polymerase chain reaction (PCR) and expressed as ratio of telomeric DNA (T) to β‐globin (S), as described previously . In each plate, telomere DNA, β‐globin, and six standard samples were measured in duplicate.…”

Section: Methodsmentioning

confidence: 99%

“…Telomere length at baseline and follow-up was measured using quantitative polymerase chain reaction (PCR) and expressed as ratio of telomeric DNA (T) to β-globin (S), as described previously. 21,22 In each plate, telomere DNA, β-globin, and six standard samples were measured in duplicate. In addition, an experimental control (HepG2 DNA) was analyzed on the same plate and used as normalizing factor to adjust individual T/S readings to obtain a final T/S ratio (adjusted T/S ratio).…”

Section: Measurement Of Ltlmentioning

confidence: 99%

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Ethnic disparities in relationships of obesity indices with telomere length in Asians with type 2 diabetes

Gurung

Yiamunaa

Liu

et al. 2018

Journal of Diabetes

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Background Obesity and shorter telomeres increase the risk for diabetes complications and mortality. However, the relationship between obesity and telomere length in diverse Asian populations with type 2 diabetes (T2D) is not well understood. This study examined the association of baseline and changes in obesity indices with telomere length in multiethnic Asian populations with T2D. Methods Leukocyte telomere length (LTL) was measured by quantitative polymerase chain reaction in the SMART2D cohort (n = 1431 at baseline, n = 1039 after 3.2 years median follow‐up). Associations between obesity indices and LTL were assessed by linear regression. Results Compared with Chinese, LTL was longer in Malays (P < 0.0001) and similar in Indians. Cross‐sectionally, body mass index (BMI)‐adjusted (residual) visceral fat area (VFA; β = −0.004, P = 0.006), and waist‐to‐hip ratio (β = −1.95, P = 0.030) were significantly associated with LTL in Chinese but not in Malays and Indians. Changes in BMI (r = −0.080; P = 0.053) and VFA (r = −0.126; P = 0.002) were inversely correlated with changes in LTL only in Chinese. Furthermore, in Chinese, 1‐SD incremental changes in BMI (β = −0.070; P = 0.040) and VFA (β = −0.088, P = 0.028) were significantly associated with larger telomere attrition, independent of age, sex, diabetes condition, baseline LTL, obesity, and inflammation markers. Conclusions Three‐year changes in BMI and VFA were associated with telomere dynamics in Chinese but not in Malays and Indians with T2D. Reducing obesity may reduce the risk of diabetes complications associated with shorter LTL in the Chinese population.

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

Section: Measurement Of Ltlmentioning

confidence: 99%

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Ethnic disparities in relationships of obesity indices with telomere length in Asians with type 2 diabetes

Gurung

Yiamunaa

Liu

et al. 2018

Journal of Diabetes

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“…Furthermore, acute myocardial infarction and reperfusion accelerate immunosenescence in cytomegalovirus-seropositive patients [ 100 ]. LTL attrition also associates with obesity [ 101 , 102 ] and with the presence and number of diabetic complications in type 2 diabetes patients [ 103 , 104 , 105 , 106 , 107 , 108 , 109 ]. It has been recently shown that reducing obesity may reduce the risk of diabetes complications associated with shorter LTL, at least in some Chinese population [ 110 ].…”

Section: Telomere Length In Age-associated Diseasesmentioning

confidence: 99%

Early Senescence and Leukocyte Telomere Shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection?

Solana¹,

Pereira²,

Tarazona

2018

Brain Sciences

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Schizophrenia is a severe, chronic mental disorder characterized by delusions and hallucinations. Several evidences support the link of schizophrenia with accelerated telomeres shortening and accelerated aging. Thus, schizophrenia patients show higher mortality compared to age-matched healthy donors. The etiology of schizophrenia is multifactorial, involving genetic and environmental factors. Telomere erosion has been shown to be accelerated by different factors including environmental factors such as cigarette smoking and chronic alcohol consumption or by psychosocial stress such as childhood maltreatment. In humans, telomere studies have mainly relied on measurements of leukocyte telomere length and it is generally accepted that individuals with short leukocyte telomere length are considered biologically older than those with longer ones. A dysregulation of both innate and adaptive immune systems has been described in schizophrenia patients and other mental diseases supporting the contribution of the immune system to disease symptoms. Thus, it has been suggested that abnormal immune activation with high pro-inflammatory cytokine production in response to still undefined environmental agents such as herpesviruses infections can be involved in the pathogenesis and pathophysiology of schizophrenia. It has been proposed that chronic inflammation and oxidative stress are involved in the course of schizophrenia illness, early onset of cardiovascular disease, accelerated aging, and premature mortality in schizophrenia. Prenatal or neonatal exposures to neurotropic pathogens such as Cytomegalovirus or Toxoplasma gondii have been proposed as environmental risk factors for schizophrenia in individuals with a risk genetic background. Thus, pro-inflammatory cytokines and microglia activation, together with genetic vulnerability, are considered etiological factors for schizophrenia, and support that inflammation status is involved in the course of illness in schizophrenia.

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Correlation of Telomere Length in Adipose Tissue and Leukocytes and its Association with Postsurgical Weight Loss

Gurung

Yiamunaa

Moh

et al. 2020

Obesity

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ObjectiveThe aim of this study was to determine the relationship between telomere length (TL) in subcutaneous adipose tissue (SAT), visceral adipose tissues (VAT), and leukocytes, as well as to examine the associations of TL in these tissues with postsurgical weight loss in Asians with severe obesity.MethodsPresurgery TL was measured in leukocytes, SAT, and VAT of 91 patients who underwent weight loss surgery. Correlation between TL in multiple tissues was assessed using Pearson correlation. The association of presurgery TL and postsurgical weight loss at 6 or 12 months, expressed as a percentage of weight loss, was determined using linear regression in 70 patients.ResultsTelomeres were longer in VAT compared with those in leukocytes and SAT (P < 0.001) but were highly correlated between tissues. The strongest correlation was observed between TL in VAT and leukocytes (r = 0.739, P = 6.22 × 10−17). Compared with individuals in the highest tertile, those in the lowest tertile of VAT TL showed greater weight loss (β = 6.23, SE = 3.10, P = 0.044) independent of age, sex, ethnicity, types of surgery, diabetes condition, preoperative BMI, and follow‐up period.ConclusionsAmong patients with severe obesity, TL in leukocytes and adipose tissue was highly correlated. However, there was variability in the association of TL in these tissues with weight loss after surgery.

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Short Leukocyte Telomere Length Predicts Albuminuria Progression in Individuals With Type 2 Diabetes

Cited by 28 publications

References 56 publications

Ethnic disparities in relationships of obesity indices with telomere length in Asians with type 2 diabetes

Ethnic disparities in relationships of obesity indices with telomere length in Asians with type 2 diabetes

Early Senescence and Leukocyte Telomere Shortening in SCHIZOPHRENIA: A Role for Cytomegalovirus Infection?

Correlation of Telomere Length in Adipose Tissue and Leukocytes and its Association with Postsurgical Weight Loss

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