This study investigated the effects of hyper-awareness meditation training on psychological symptom clusters in stroke patients. A controlled clinical trial was conducted in which stroke patients were recruited and randomly assigned to a hyper-awareness meditation group and a control group. The psychological symptoms assessed included anxiety, depression, cognition and quality of life levels. Patients in the hyper-awareness meditation group received training sessions focused on this meditation technique, while the control group received standard care with no additional meditation training. A total of 200 patients participated in the study, 100 in each group. Psychological assessments were conducted at baseline, immediately after the end of the intervention, and after 10 days. The results showed that patients in the transcendental awareness meditation group showed significant improvements in psychological symptoms compared to the control group. Anxiety and depression scores decreased significantly and overall psychological well-being improved significantly; thus, hyper-awareness meditation training was found to significantly improve psychological symptoms and reduce stress responses in stroke patients. These findings suggest that incorporating hyper-awareness meditation into a rehabilitation programs for stroke patients may provide significant benefits for mental health and stress management. Further research is recommended to explore the long-term effects of these benefits and their underlying mechanisms.