Short photoperiod condition increases susceptibility to stress in adolescent male rats

Xu, Lingzhi; Liu, Li-Jing; Yuan, Mengmeng; Li, Suxia; Yue, Xiaodong; Lai, Julian C. L.; Lü, Lin

doi:10.1016/j.bbr.2015.12.002

Cited by 18 publications

(11 citation statements)

References 37 publications

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“…Sucrose preference and immobility time in the FST are core symptoms of depression, which reflect the depression-like state, such as anhedonia and despair 36 , 40 . The EPM and NSFT are well-established behavioral model of anxiety 40 , and the OFT was used to measure the exploratory locomotor activity of animals 41 . Previous studies reported that maternal separation would not change basal sucrose preference in adolescent rats 42 and adult rats 43 – 45 , which were consistent with our findings.…”

Section: Discussionmentioning

confidence: 99%

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Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress

Zhang

et al. 2017

Sci Rep

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Stress is a major risk factor for psychiatric disorders, such as depression, posttraumatic stress disorder, and schizophrenia. Early life stress, such as maternal separation, can have long-term effects on the development of the central nervous system and pathogenesis of psychiatric disorders. In the present study, we found that maternal separation increased the susceptibility to stress in adolescent rats, increased the expression of Na+/K+/2Cl− cotransporter 1 (NKCC1) on postnatal day 14, and increased the expression of K+/2Cl− cotransporter 2 (KCC2) and γ-aminobutyric acid A (GABAA) receptor subunits on postnatal day 40 in the hippocampus. NKCC1 inhibition by the U.S. Food and Drug Administration-approved drug bumetanide during the first two postnatal weeks rescued the depressive- and anxiety-like behavior that was induced by maternal separation and decreased the expression of NKCC1, KCC2 and GABAA receptor α1 and β2,3 subunits in the hippocampus. Bumetanide treatment during early development did not adversely affect body weight or normal behaviors in naive rats, or affect serum osmolality in adult rats. These results suggest that bumetanide treatment during early development may prevent the maternal separation-induced susceptibility to stress and impairments in GABAergic transmission in the hippocampus.

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Section: Discussionmentioning

confidence: 99%

“…The open field test (OFT) was performed to assess exploratory locomotor activity in an unfamiliar environment as a rat model of depression, and this model mimics some aspects of human depression, including lower levels of activity, and lack of interest 41 . The test was conducted in a dark room.…”

Section: Methodsmentioning

confidence: 99%

Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress

Zhang

et al. 2017

Sci Rep

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“…Natural rhythms in melatonin release can, however, be interrupted by artificial light (Le Tallec et al 2013). Moreover, it has been demonstrated that artificial interruptions to the typical circadian rhythm in melatonin can act as a stressor, and thus increase 230 CORT levels (Xu et al 2016). It is possible, consequently, that a combination of handling, experiments, and artificial light interacting with circulating CORT and melatonin may be the underlying cause for the poorer feather stiffness in the captive geese compared to their wild counterparts.…”

Section: Discussionmentioning

confidence: 99%

Mechanics Of Flight Feathers: Effects Of Captivity?

Portugal

Nudds

Green

et al. 2020

Preprint

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Deceased 20 25 2 ABSTRACT Feathers act as aerodynamic cantilevers, and to withstand the prolonged cyclical loading that occurs during flight, feathers must be stiff, lightweight and strong. We experimentally tested the 30 differences in feather structure, primarily stiffness and size, between (a) wild and captive Barnacle Geese Branta leucopsis, and (b) primary feathers dropped during the annual flight feather moult, and those feathers freshly regrown during the moult process. We found that, despite having undergone a 5,000km round-trip migration, flight feathers dropped during moult in the wild geese were stiffer than those measured in the captive geese, both for those dropped during moult and 35 those re-grown. We propose that this may be related to diet or stress in the captive geese.

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“…Recently, similar exacerbating effects of LD disruption have been reported in several disease models. A short photoperiod increased the susceptibility of rats to chronic mild stress that induced depression (33). Constant light exacerbated the symptoms of schizophrenia in mutant mice that had a loss-of-function mutation in the schizophrenia risk gene (4).…”

Section: Treatmentmentioning

confidence: 99%

<b>Short and long photoperiods differentially exacerbate corticosterone-induced physical and psychological symptoms in </b><b>mice </b>

et al. 2018

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Circadian disruption affects the pathogenesis and development of various diseases. Depression is one of the most common diseases that relate to circadian rhythm. In this study, we analyzed the effects of daily light/dark (LD) conditions on depression and other symptoms, and also analyzed the mixed effects of LD conditions and corticosterone treatment. Male adult C57BL/6 mice were treated with corticosterone in a normal LD cycle of 12 hours light and 12 hours dark (LD12 : 12), short day conditions of 6 hours light and 18 hours dark (LD6 : 18), or long day conditions of 21 hours light and 3 hours dark (LD21 : 3). The activity rhythms of mice in aberrant LD conditions were entrained within 2 weeks. After 6 weeks of exposure, several behavioral tests were conducted. Corticosterone induced body weight gain and depression-like symptoms. The short or long LD conditions had little effect on vehicle-treated mice behavior. However, the aberrant LD conditions exacerbated the corticosterone-induced symptoms. Mice treated with corticosterone in LD6 : 18 showed exacerbated depression-like symptoms in a novelty suppressed feeding test. On the other hand, LD21 : 3 did not show any effects on mood, but enhanced corticosterone-induced body weight gain. These results indicated that aberrant LD conditions could act as an exacerbating factor for corticosterone-induced symptoms, and that short and long photoperiods induce different psychological and physiological changes. This corticosterone + aberrant LD model could be a useful animal model for investigating the effect of LD conditions on depression, obesity, and other symptoms in stressful circumstances.

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Short photoperiod condition increases susceptibility to stress in adolescent male rats

Cited by 18 publications

References 37 publications

Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress

Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress

Mechanics Of Flight Feathers: Effects Of Captivity?

<b>Short and long photoperiods differentially exacerbate corticosterone-induced physical and psychological symptoms in </b><b>mice </b>

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