Short Physical Performance Battery (SPPB) and Its Relationship with the Predisposition to Muscle and Joint Injuries Associated with the COL1A1 and IL-6 Gene in Older Adults

Abstract

Background/Objectives: Aging leads to physiological changes influenced by lifestyle, environment, and genetics, increasing the risk of morbidity and mortality in older adults. COL1A1 gene encodes an essential protein in connective tissues, which is associated with musculoskeletal lesions. The interleukin-6 (IL-6) gene is a proinflammatory and anti-inflammatory regulator and has a greater predisposition to fractures and osteoporosis reported. In turn, these alterations are associated with a decrease in physical capacity, leading to a progressive loss of functionality and quality of life in older adults. Methods: A cross-sectional study was designed to identify the relationship between physical condition as determined using the Short Physical Performance Battery (SPPB) and the predisposition parameters for muscle and joint injuries in a population of 422 older adults, active and of ≥60 years. The variables evaluated were sociodemographic data, SPPB evaluation, and COL1A1 and IL-6 gene DNA extracted by buccal scraping. Results: SPPB total score was significantly correlated with age −0.07, weight −0.02, waist circumference −0.02, and body mass index −0.05 (p < 0.005). Conclusions: Regarding genetic variables, there were no significant differences. However, lower SPPB values were observed in the GG genotype and GT of COL1A1 when compared to the CC genotype and GC of IL-6.