Short-range connections in the developmental connectome during typical and atypical brain maturation

Ouyang, Minhui; Kang, Huibin; Detre, John A.; Roberts, Timothy P. L.; Huang, Hao

doi:10.1016/j.neubiorev.2017.10.007

Cited by 97 publications

(90 citation statements)

References 159 publications

(235 reference statements)

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“…Increased interhemispheric connectivity during AS, that is consistently observed across three independent analyses, may reflect the importance of AS in the functional organization of the developing brain in the absence of sensory stimulation. The prominence of long-range connectivity during AS compared to short-range connectivity during QS may indicate that each sleep state fulfils a different role during the early development of functional networks (Ouyang et al, 2017). This work highlights the importance of monitoring sleep in studies of neonatal resting-state functional connectivity.…”

Section: Resultsmentioning

confidence: 91%

Sleep State Modulates Resting-State Functional Connectivity in Neonates

et al. 2020

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The spontaneous cerebral activity that gives rise to resting-state networks (RSNs) has been extensively studied in infants in recent years. However, the influence of sleep state on the presence of observable RSNs has yet to be formally investigated in the infant population, despite evidence that sleep modulates resting-state functional connectivity in adults. This effect could be extremely important, as most infant neuroimaging studies rely on the neonate to remain asleep throughout data acquisition. In this study, we combine functional near-infrared spectroscopy with electroencephalography to simultaneously monitor sleep state and investigate RSNs in a cohort of healthy term born neonates. During active sleep (AS) and quiet sleep (QS) our newborn neonates show functional connectivity patterns spatially consistent with previously reported RSN structures. Our three independent functional connectivity analyses revealed stronger interhemispheric connectivity during AS than during QS. In turn, within hemisphere short-range functional connectivity seems to be enhanced during QS. These findings underline the importance of sleep state monitoring in the investigation of RSNs.

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Section: Resultsmentioning

confidence: 91%

Sleep State Modulates Resting-State Functional Connectivity in Neonates

et al. 2020

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“…thalamocortical), and so called ‘rich‐club’ hubs (densely connected network hub regions) (Ouyang et al . ).…”

Section: Introductionmentioning

confidence: 97%

“…Notably, short‐range structural connectivity plays a key role in how the brain develops and in mediating our neurocognitive function after we are born (Ouyang et al . ). In contrast, there is a linear development of long‐range connections throughout gestation (Jakab et al .…”

Section: Introductionmentioning

confidence: 97%

Waking up too early – the consequences of preterm birth on sleep development

Bennet

Walker

Horne

2018

The Journal of Physiology

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Good quality sleep of sufficient duration is vital for optimal physiological function and our health. Sleep deprivation is associated with impaired neurocognitive function and emotional control, and increases the risk for cardiometabolic diseases, obesity and cancer. Sleep develops during fetal life with the emergence of a recognisable pattern of sleep states in the preterm fetus associated with the development, maturation and connectivity within neural networks in the brain. Despite the physiological importance of sleep, surprisingly little is known about how sleep develops in individuals born preterm. Globally, an estimated 15 million babies are born preterm (<37 weeks gestation) each year, and these babies are at significant risk of neural injury and impaired brain development. This review discusses how sleep develops during fetal and neonatal life, how preterm birth impacts on sleep development to adulthood, and the factors which may contribute to impaired brain and sleep development, leading to altered neurocognitive, behavioural and motor capabilities in the infant and child. Going forward, the challenge is to identify specific risk factors for impaired sleep development in preterm babies to allow for the design of interventions that will improve the quality and quantity of sleep throughout life.

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“…The first functional connectome component (FCC 1) showed short-range functional connectivity between adjacent channels, spanning our whole fNIRS optode setup. This functional connectivity pattern reflecting the intrinsic functional configuration of the infant brain has been shown to progressively decrease over the course of development, whereas long distance connections tend to increase towards a more distributed functional brain organization (Homae et al, 2010; Ouyang et al, 2017). The second component (FCC 2) displayed interhemispheric correlations between homotopic regions.…”

Section: Discussionmentioning

confidence: 99%

Monolingual and bilingual infants rely on the same brain networks: Evidence from resting-state functional connectivity

Blanco

Molnar

Carreiras

et al. 2020

Preprint

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15This study examines whether bilingual exposure has a profound effect on the functional organization of the 16 developing human brain during infancy. Recent behavioural research attests that monolingual vs. bilingual 17 experience affects cognitive and linguistic processes already during the first months of life. However, to what 18 extent the intrinsic organization of the infant human brain adapts to monolingual vs. bilingual environments is 19 unclear. We measured spontaneous hemodynamic brain activity using functional near-infrared spectroscopy 20 (fNIRS) in a large cohort (N=99) of 4-month-old monolingual and bilingual infants. We implemented well-21 established analysis approaches of functional brain imaging that enabled us to reveal the functional organization 22 of the infant brain in large-scale cortical networks, and to perform group-level comparisons (i.e., monolingual 23 vs. bilingual groups) in a reliable manner. Our results revealed no differences between the intrinsic functional 24 organization of the developing monolingual and bilingual infant brain at 4 months of age. 26Keywords: Functional connectivity, functional near-infrared spectroscopy, brain development, language 27 acquisition, bilingualism, independent component analysis, connectome . 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 85 profound effect on the developing human brain, such as its functional organization, is currently unknown. 86Measuring RSFC in monolingual and bilingual infants can reflect whether bilingual experience during the first 87 months of life leads to specific adaptations in the intrinsic properties of brain's function that are observable in 88 the absence of any task or stimuli (i.e., at rest). Testing whether functional adaptation to a bilingual context is 89 evident at the earliest stages of human development is crucial for our understanding of how bilingualism interacts 90 with general brain maturation patterns beyond task-specific language and cognitive processing. There is evidence 91 that long-term exposure to two languages might alter the brain's functional (Parker Jones et al., 2011; Berken 92 et al., 2016) and structural organization (Mechelli et al., 2004; García-Pentón et al., 2014; Mohades et al., 93 2015), as demonstrated by MRI studies in adults. For instance, stronger functional connectivity in bilingual 94 adults as compared to monolinguals has been observed in long-range bilateral and anterior-posterior connections 95 on both hemispheres (Luk et al., 2011), and in brain networks associated with language and executive control 96 processes (Grady et al., 2015; Berken et al., 2016). The aim of the current study is to assess whether the brain's 97 functional architecture begins to adapt to a bilingual environment as early as 4 months of age, by the time neural 98 and behavioural responses to external stimuli often differ across monolinguals and bilinguals. Specifically, the 99 current goal is to contrast the RSFC across monolingual and bilingual 4-month-old infants using fun...

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Short-range connections in the developmental connectome during typical and atypical brain maturation

Cited by 97 publications

References 159 publications

Sleep State Modulates Resting-State Functional Connectivity in Neonates

Sleep State Modulates Resting-State Functional Connectivity in Neonates

Waking up too early – the consequences of preterm birth on sleep development

Monolingual and bilingual infants rely on the same brain networks: Evidence from resting-state functional connectivity

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