Short report: high‐dose omeprazole and amoxycillin in the treatment of Helicobacter pylori‐associated duodenal ulcer

Abstract

Thirteen consecutive patients with active duodenal ulcer disease were assigned to a treatment schedule with high-dose omeprazole and amoxycillin. Duodenal ulcer was diagnosed endoscopically in all patients, at which time antral biopsies were taken for culture and histology. All were positive for Helicobacter pylori and histological gastritis. Treatment was for 2 weeks : 80 mg omeprazole daily plus 500 mg amoxycillin

Dual proton pump inhibitor plus amoxicillin as an empiric anti-H. pylori therapy: studies from the United States

“…Amoxicillin and PPI dual therapy eventually fell into disfavor because it did not reliably produce high cure rates and it was replaced by triple therapy consisting of a PPI, amoxicillin, and clarithromycin or metronidazole [16]. However, a number of studies suggested that good success rates for H. pylori eradication could be obtained with dual therapy if the dose of the PPI were increased [17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32]. Improved results were also obtained by increasing the PPI dose with triple therapy, and it appears that this improvement was most likely related to the increase in treatment success based on improvement in the dual PPIamoxicillin component of the triple therapy [14,33,34].…”